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RASSF1 encodes a protein similar to the RAS effector proteins.
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Human RASSF1 ELISA Kit for Sandwich ELISA - ABIN4947994
Strzelczyk, Gołąbek, Cuber, Krakowczyk, Owczarek, Fronczek, Choręża, Hudziec, Ostrowska: Comparison of Selected Protein Levels in Tumour and Surgical Margin in a Group of Patients with Oral Cavity Cancer. in Biochemical genetics 2017
Promoter methylation of RASSF1A can influence sensitivity to oxaliplatin-based chemotherapy, which can be used to predict outcomes for patients with stage II and III Colorectal Cancer
The meta-analysis indicates a role of the RASSF1A promoter hypermethylation from peripheral blood in testicular germ cell tumors.
RASSF1A is a tumour suppressor gene epigenetically dysregulated in NET. Aberrant methylation of RASSF1A has been reported in various tumours, but this is the first report of RASSF1A hypermethylation in TETs.
Study shows that recombinant human bone morphogenetic protein-2 (show BMP2 ELISA Kits) activates hippo signaling through RASSF1 in esophageal cancer cells
There were significant associations between RASSF1A promoter hypermethylation and Oral Cancer risk.RASSF1A promoter hypermethylation exerted higher frequency in the Tongue Tumor than other site tumor in mouth.
RASSF1A is expressed in differentiating stem cells.
Hypermethylation of RASSF1A gene is associated with Colon Cancer.
Data show that silencing DNA methyltransferase 1 (DNMT1 (show DNMT1 ELISA Kits)) increased expression of tumor suppressor genes, RASSF1A and DAPK (show DAPK1 ELISA Kits), in esophageal squamous cell carcinoma (ESCC) cells and ESCC xenograft in nude mice.
Describe a novel interaction between Rheb and the tumor suppressor RASSF1A. This interaction may allow coordinate upregulation of Hippo while TOR is suppressed to modulate the balance of apoptosis and autophagy in lung tumor cells.
Nine of the 32 (28.1%) iCCA patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 mutations, two each (6.3%) of CACNA2D3 and RASSF1 mutations, and one each (3.1%) of ATG7 and PLCD1 mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations.
RASSF1A is expressed in differentiating stem cells.RASSF1A promotes YAP and p73 binding to differentiation related genes.RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.
beta-catenin (show CTNNB1 ELISA Kits) was predominantly associated with Na+/H+ exchanger regulating factor 1 (NHERF1) in a dynamic context and an increase of its oncogenic function through RAS-association domain family 1, isoform A (RASSF1A) inactivation in liver metastases.
essential role of RASSF1A in regulating TNF-alpha (show TNF ELISA Kits) signalling in cardiomyocytes, with RASSF1A being key in the formation of the TNFR (show TNFRSF1A ELISA Kits) complex and in signal transmission to the downstream targets
RASSF1A may function to interfere and restrict TLR-driven activation of NF-kappaB (show NFKB1 ELISA Kits) and is essential for protection against inflammation-induced injury.
nickel-smelting fumes upregulated the expression of RASSF1A. This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.
Loss of RASSF1A synergizes with deregulated RUNX2 (show RUNX2 ELISA Kits) signaling in tumorigenesis.
Concomitant with the loss of Rassf1a, the loss of p53 (show TP53 ELISA Kits) (which causes unrestrained propagation of tetraploids into aneuploid cells) further undermines genomic stability and accelerates tumorigenesis.
Data show that methylation of CCND-2 (show CCND2 ELISA Kits), p16, RAR-beta (show RARB ELISA Kits) and RASSF-1a was significantly more prevalent in tumor than in normal tissue specimens.
Rassf1A acts as a tumor suppressor gene.
cooperation between inactivation of Rassf1a and Apc (show APC ELISA Kits) resulting in accelerated intestinal tumourigenesis.
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Ras association (RalGDS/AF-6) domain family 1
, Ras association (RalGDS/AF-6) domain family member 1
, ras association domain-containing protein 1
, Ras association domain family 1
, cardiac-specific ras association domain family 1 protein
, pancreas-specific ras association domain family 1 protein
, tumor suppressor protein RDA32
, 123F protein
, RASSF1A tumor suppressor
, protein 123F2