Ras Homolog Gene Family, Member T1 Proteins (RHOT1)

Mitochondrial GTPase involved in mitochondrial trafficking. Additionally we are shipping RHOT1 Antibodies (54) and RHOT1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RHOT1 55288 Q8IXI2
RHOT1 59040 Q8BG51
Rat RHOT1 RHOT1 303351  
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Top RHOT1 Proteins at antibodies-online.com

Showing 3 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,493.38
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details

RHOT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)
,

More Proteins for Ras Homolog Gene Family, Member T1 (RHOT1) Interaction Partners

Human Ras Homolog Gene Family, Member T1 (RHOT1) interaction partners

  1. The findings identify for the first time peroxisome-localized Miro1 variants as adapter proteins that link peroxisomes to the microtubule-dependent transport complexes including TRAK2 in the intracellular translocation of peroxisomes in mammalian cells.

  2. LPS mediates intercellular tight junction destruction among TECs and RhoT1/SMAD-4/JAM-3 is a pivotal pathway to mediate the phenomenon.

  3. a key role of Miro1, which promotes the mitochondrial transfer from multipotent mesenchymal stem cells, is reported.

  4. Show that the C-terminal GTPase of the Parkin primary substrates Miro1 and Miro2 are necessary and sufficient for efficient ubiquitination. We present several new X-ray crystal structures of both Miro1 and Miro2 that reveal substrate recognition and ubiquitin transfer to be specific to particular protein domains and lysine residues.

  5. Results provide evidence that ALS mutant SOD1 inhibits axonal transport of mitochondria by inducing PINK1/Parkin-dependent Miro1 degradation.

  6. prolonged retention of Miro, and the downstream consequences that ensue, may constitute a central component of Parkinson's disease pathogenesis.

  7. Full-length APC promotes assembly of the Miro-1/Milton-2 complex.

  8. Miro and Cenp-F promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells.

  9. Data indicate that outer mitochondrial membrane protein Miro1 can stabilize phospho-mutant versions of PARK2 gene (encoding Parkin) on the outer mitochondrial membrane (OMM).

  10. Details of a robust association of DISC1 with mitochondrial transport complexes containing TRAK1 and Miro1.

  11. The Miro1-mediated mitochondrial transport in neurons and recently highlighted involvement of Miro1 proteins in mitochondrial turnover, emerging as a key process affected in neurodegeneration.

  12. CXCL12-dependent cell polarization and migration are reduced in Miro-1-silenced cells

  13. results indicated that the low-expression levels of RhoT1 and Smad4 were significantly associated with LNM and shorter survival. RhoT1 may be considered as a potential novel marker for predicting the outcome in patients with pancreatic cancer

  14. Study shows that both PINK1 and Parkin halt mitochondrial movement; PINK1 phosphorylates Miro (1 and 2) and thereby initiates the rapid degradation of Miro through a Parkin- and proteasome-dependent pathway.

  15. Moreover, we show that Miro interacts with the Kinesin-binding proteins, GRIF-1 and OIP106, suggesting that the Miro GTPases form a link between the mitochondria and the trafficking apparatus of the microtubules.

  16. Miro1,2 proteins serve as a [Ca(2+)](c)-sensitive switch and bifunctional regulator for both the motility and fusion-fission dynamics of the mitochondria.

  17. These data suggest that Miro1 and the kinesin adaptor Grif-1 play an important role in regulating mitochondrial transport in neurons.

Mouse (Murine) Ras Homolog Gene Family, Member T1 (RHOT1) interaction partners

  1. MIRO1 is an adaptor for microtubule-dependent peroxisome motility in cultured cells. MIRO1 is targeted to peroxisomes and alters their distribution and motility.

  2. both Miro proteins can act to coordinate microtubule-dependent and actin-dependent mitochondrial trafficking, Miro1 preferentially acts to control microtubule-dependent trafficking through kinesin and dynein, while Miro2 plays a more prominent role in coordinating mitochondrial interactions with the actin cytoskeleton through a more efficient recruitment and stability of endogenous Myo19 in the mitochondrial membrane.

  3. Using mouse knockout strategies, we demonstrate that Miro1, as opposed to Miro2, is the primary regulator of mitochondrial transport in both axons and dendrites. Miro1 deletion leads to depletion of mitochondria from distal dendrites but not axons, accompanied by a marked reduction in dendritic complexity. Disrupting postnatal mitochondrial distribution in vivo by deleting Miro1 in mature neurons causes a progressive loss

  4. Data establish that Miro1-mediated mitochondrial positioning at the leading edge provides localized energy production that promotes cell migration by supporting membrane protrusion and focal adhesion stability.

  5. This study demonstrated that Miro1 regulates trafficking of mitochondria in the processes of astrocytes, as well as retention of mitochondria at sites that require energy production and Ca2+-buffering such as the tripartite synapse

  6. Neuron-specific loss of Miro1 causes depletion of mitochondria from corticospinal tract axons and progressive neurological deficits mirroring human upper motor neuron disease.

  7. Miro1 overexpression leads to increased stem cell repair.

  8. Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro 1/2 and Trak2.

RHOT1 Protein Profile

Protein Summary

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).

Gene names and symbols associated with RHOT1

  • ras homolog family member T1a (rhot1a)
  • ras homolog family member T2 (rhot2)
  • ras homolog family member T1 (RHOT1)
  • ras homolog family member T1 (rhot1)
  • ras homolog family member T1 L homeolog (rhot1.L)
  • ras homolog family member T1 (Rhot1)
  • ras homolog family member T1 (rhot1b)
  • 2210403N23Rik protein
  • AA415293 protein
  • AF244542 protein
  • AI834919 protein
  • Arht1 protein
  • arht2 protein
  • C430039G08Rik protein
  • MIRO-1 protein
  • miro-2 protein
  • miro1 protein
  • rasl protein
  • rhot1 protein
  • si:dkeyp-97g3.6 protein
  • wu:fd14e11 protein
  • wu:fi14a05 protein
  • zgc:55581 protein
  • zgc:77063 protein

Protein level used designations for RHOT1

MIRO-1-A , mitochondrial Rho GTPase 1-A , ras homolog gene family member T1-A , ras homolog gene family, member T1 , mitochondrial Rho GTPase 2 , ras homolog gene family, member T2 , MIRO-1 , mitochondrial Rho GTPase 1 , ras homolog gene family member T1 , hMiro-1 , mitochondrial Rho (MIRO) GTPase 1 , mitochondrial Rho 1 , rac-GTP binding protein-like protein , rac-GTP-binding protein-like protein , Rhot1a

GENE ID SPECIES
327143 Danio rerio
448378 Xenopus (Silurana) tropicalis
100022962 Monodelphis domestica
100560389 Anolis carolinensis
100592519 Nomascus leucogenys
100158403 Xenopus laevis
417410 Gallus gallus
55288 Homo sapiens
480613 Canis lupus familiaris
100523466 Sus scrofa
511257 Bos taurus
59040 Mus musculus
303351 Rattus norvegicus
561933 Danio rerio
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