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Guanine nucleotide exchange factor (GEF) with specificity for RAP2A and other Ras family proteins (in vitro) (By similarity). Additionally we are shipping RasGEF Domain Family, Member 1B Proteins (6) and and many more products for this protein.
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We show that knockdown of the expression of mcircRasGEF1B reduces LPS-induced ICAM-1 expression. Additionally, we demonstrate that mcircRasGEF1B regulates the stability of mature ICAM-1 mRNAs.
As an addition to PRKG2 and RASGEFIB genes, we propose to include BMP3 gene as the principal determinant of the observed common phenotype.
Mutation of the Ser39 in Rap1 changed the specificity and allowed the nucleotide exchange of Rap1(S39F) to be stimulated by RasGEF1B
The authors show that knockdown of the lipopolysaccharide (LPS)-induced cytoplasmic circular RNA, mcircRasGEF1B, results in altered expression of a wide array of genes. Pathway analysis revealed an overall enrichment of genes involved in cell cycle progression, mitotic division, active metabolism, and of particular interest, NF-kappaB, LPS signaling pathways, and macrophage activation.
Upon toll-like receptor activation, RasGEF1b may trigger Ras-like proteins and regulate specific biological activities of macrophages.
Guanine nucleotide exchange factor (GEF) with specificity for RAP2A and other Ras family proteins (in vitro) (By similarity).
, GPI gamma-4
, GPI-gamma 4
, ras-GEF domain-containing family member 1B