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In mouse, recombining binding protein L (RBP-L) is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signalling pathway transcription factor RBP-J. Additionally we are shipping RBPJL Antibodies (37) and and many more products for this protein.
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In mouse, there is cooperative transcriptional activity of RBP-L with EBNA-2.
P48 interacts with the RBP-L and RBP-J subunits primarily through two short conserved tryptophan-containing motifs, similar to the motif of the Notch intracellular domain (NotchIC) that interacts with RBP-J.
Notch1 (show NOTCH1 Proteins)/RBP-J (show RBPJ Proteins) signaling induces expression of key transcriptional regulators involved in cell lineage determination in the absence of protein synthesis
Replacement of Rbpj by Rbpjl in the PTF1 complex drives acinar differentiation by maximizing secretory protein synthesis.
RBPJL is the third subunit of an unusual bHLH factor complex that binds and activates pancreatic acinar specific genes
During pancreatic acinar development, Rbpjl replaces Rbpj in the PTF1 complex residing on active acinar specific promoters.
In mouse, recombining binding protein L (RBP-L) is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signalling pathway transcription factor RBP-J. However, unlike RBP-J, RBP-L does not interact with Notch receptors. RBP-L has been shown to activate transcription in concert with Epstein-Barr virus nuclear antigen-2 (EBNA2). The protein encoded by this gene is similar in sequence to the mouse RPB-L protein and Drosophila suppressor of hairless protein.
recombining binding protein suppressor of hairless-like
, recombination signal binding protein for immunoglobulin kappa J region-like
, recombining binding protein L
, recombining binding protein suppressor of hairless-like protein
, recombining binding protein L, 3 prime
, recombining binding protein L, 5 prime
, recombining binding protein suppressor of hairless-like protein-like
, transcription factor RBP-L
, RBP-J kappa-like