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RFX1 is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. Additionally we are shipping Regulatory Factor X, 1 (Influences HLA Class II Expression) Antibodies (46) and many more products for this protein.
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RFX1 expression was significantly lower in HCC (show FAM126A Proteins) tissues compared to the corresponding non-tumor tissues. In vitro studies suggested that knocking down RFX1 facilitated HCC (show FAM126A Proteins) cell invasion, while overexpression of RFX1 reduced the invasion of HCC (show FAM126A Proteins) cells. RFX1 regulated expression of some epithelial-mesenchymal transition markers.
Findings indicate that RFX1 functions downstream of STAT3 (show STAT3 Proteins) and phosphorylated STAT3 (show STAT3 Proteins) can inhibit RFX1 expression and suggest a unique role for RFX1 in Th17-related autoimmune diseases.
Results show that reduced miRNA-124 improved microglia activation and up-regulated its downstream target RFX1, indicating that RFX1, as one of the target transcripts, facilitates microglial activation by miR (show MLXIP Proteins)-124 regulation; identified the binding site through which RFX1 directly regulates ApoE (show APOE Proteins), may explain the missing link between decreased miRNA-124 and ineffective Abeta (show APP Proteins) uptaking during aging.
induction of ciliogenesis increases the expression of RFX and dyslexia candidate genes
Data show that transcription factor regulatory factor X 1 (RFX1) protein expression can be tightly regulated by polyubiquitination-mediated proteosomal degradation via STIP1 homology and U-box containing protein 1 (STUB1 (show STUB1 Proteins)).
Data indicate that regulatory factor X transcription factor RFX-1 regulates SC-2001-mediated SHP-1 Phosphatase transcription in hepatocellular carcinoma cells.
regulatory factor 1 directly regulates CD44 (show CD44 Proteins) expression in glioblastoma
Taken together, this study suggests ciliogenic RFX transcription factors regulate FGF-1B promoter activity and the maintenance of F1BGFP(+) NSPCs and GBM-SCs (show TWIST1 Proteins).
RFX1 reduces cell proliferation through inhibiting the TGFbeta2-ERK (show EPHB2 Proteins) signaling pathway. RFX1 blocks TGFbeta2 expression through its direct action on TGFbeta2 transcription.
NLRC5-mediated histocompatibiility class I gene induction requires the W/S and X1, X2 cis (show CISH Proteins)-regulatory elements.
RFX1 transcriptionally targets Itga6 (show ITGA6 Proteins) in Sertoli cells, thereby, helping maintain the integrity of the basal lamina during testis cord development.
This study suggests that ciliogenic Rfx transcription factors regulate Msi1 (show MSI1 Proteins) expression in neural stem/progenitor cells.
RFX1 may have negative effect on cell proliferation of Sertoli cells via modulating Spata4 expression levels by binding the conserved 14-bp cis-elements of Spata4 promoter.
Rfx1 could be an indicator of progression from Barrett's esophagus to adenocarcinoma.
These results suggest a significant expression of RFX1 proteins in the mammalian brain.
RFX1 may negatively regulate the self-renewal of GBM-SCs (show TWIST1 Proteins) through modulating FGF-1B and FGF1 (show FGF1 Proteins) expression levels by binding the 18-bp cis (show CISH Proteins)-elements of the F1B promoter.
RFX1 may play roles in haploid cells during mouse spermatogenesis
RFX1 mediates the immediate early (show JUN Proteins) response of the Id2 gene by serum stimulation and suggest that the function of RFX1 is regulated intramolecularly in its suppression in growth-arrested cells.
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes.
MHC class II regulatory factor RFX
, MHC class II regulatory factor RFX1
, enhancer factor C
, regulatory factor X 1
, trans-acting regulatory factor 1
, transcription factor RFX1
, vregulatory factor X, 1 (influences HLA class II expression)
, regulatory factor X1