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The protein encoded by RP9 can be bound and phosphorylated by the protooncogene PIM1 product, a serine\\/threonine protein kinase . Additionally we are shipping RP9 Antibodies (6) and many more products for this protein.
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Mutations in a protein target of the Pim-1 kinase associated with the RP9 form of autosomal dominant retinitis pigmentosa
Has a role in pre-mRNA splicing, further evidence that PAP-1 is indeed the RP9 gene.
PAP-1 interacted with Prp3p but not Prp31p in human cells and yeast, and the basic region of PAP-1 and the C-terminal region of Prp3p, regions beside spots found in retinitis pigmentosa mutations, were needed for binding
CIR was found to be colocalized with PAP-1 in nuclear speckles.
Rp9 gene knockout & point mutation knock in (Rp9, c.A386T, P.H129L) analogous to reported one in the retinitis pigmentosa patients (RP9, c.A410T, P.H137L) were studied. Proliferation and migration were significantly decreased in the mutated cells. Gene expression profiling by RNA-Seq demonstrated that retinitis pigmentosa associated genes, Fscn2 and Bbs2, were down-regulated in the mutated cells.
The protein encoded by this gene can be bound and phosphorylated by the protooncogene PIM1 product, a serine\\/threonine protein kinase . This protein localizes in nuclear speckles containing the splicing factors, and has a role in pre-mRNA splicing. CBF1-interacting protein (CIR), a corepressor of CBF1, can also bind to this protein and effects alternative splicing. Mutations in this gene result in autosomal dominant retinitis pigmentosa-9. This gene has a pseudogene (GeneID: 441212), which is located in tandem array approximately 166 kb distal to this gene.
Pim-1 kinase associated protein
, pim-1-associated protein
, retinitis pigmentosa 9 protein
, retinitis pigmentosa 9 (autosomal dominant)
, retinitis pigmentosa 9 homolog
, Pim-1 associated protein
, retinitis pigmentosa 9 protein homolog