Retinol Binding Protein 3, Interstitial Proteins (RBP3)

Zebrafish Retinol Binding Protein 3, Interstitial (RBP3) interaction partners

1. Our study, which provides the first structure of an IRBP with bound ligand, supports a potential role for fatty acids in regulating retinoid binding.

Mouse (Murine) Retinol Binding Protein 3, Interstitial (RBP3) interaction partners

1. These data demonstrate distinguishing features of retinal inflammation and T-cell immune responses involved in IRBP-induced EAU between B10.RIII and C57BL/6 strains.

2. The 629-643 RBP-3 peptide is a major uveitogenic peptide for the induction of autoimmune uveoretinitis in C57BL/6J mice and the persistent clinical disease induced with one peptide leads to epitope spreading.

3. We propose that down-regulation of IRBP may represent an early and novel pathogenic mechanism in degenerative retinal diseases

4. Although death signaling proteins are increased, the caspase-dependent and independent apoptotic pathways are mildly activated in Irbp-deficient retinas.

5. Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP).

6. In addition to its role in the visual cycle, IRBP is needed for normal eye development.

7. IRBP is essential to normal cone function and demonstrate that differences exist in the visual cycle of rods and cones.

8. these findings suggest that IRBP plays an important role in the delivery of 11-cis-retinol to cones and can facilitate cone function in the presence of light

9. Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells.

10. analysis of the structure and sequence of the IRBP gene

11. data show that presence of IRBP is necessary in ocular and pineal gland tissues for expression of autoimmune uveitis

12. Expression of IRBP within the thymus is critical to prevent spontaneous autoimmunity against the eye, even in the presence of autoimmune regulator aire.

13. Data indicate that IRBP is essential to normal cone function and demonstrate that IRBP has a cone-specific visual cycle function.

14. Activation of IRBP-specific T cells from mice immunized with uveitogenic IRBP(1-20) peptide under T-helper cell interleukin (IL)17-polarizing conditions is associated with increased expansion of T cells expressing the gamma delta T cell receptor.

Human Retinol Binding Protein 3, Interstitial (RBP3) interaction partners

1. this report is the first to describe the retinal dystrophy in children caused by homozygous nonsense RBP3 mutations, highlighting the requirement for IRBP in normal eye development and visual function.

2. CMPK1 and RBP3 are associated with corneal curvature in Asian populations.

3. We found that most patients with macular telangiectasia-2 possess retinal autoantibodies, the most prevalent of which were directed against AGL, RBP3, and CK-B.

4. Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP).

5. The mouse retina promotes cone dark adaptation eightfold faster than the retinal pigment epithelium. However, complete cone recovery requires both visual cycles.

6. It is likely that mutations in RGR, RBP3, and possibly RBP1 occur rarely in inherited retinal dystrophies.

7. Underproduction of IRBP is an early event in the human diabetic retina and is associated with retinal neurodegeneration.

8. studies suggest that IRBP and S-Ag can initiate innate and, in sensitive individuals, adaptive immune response by attracting iDCs and T and B cells expressing CXCR3 and CXCR5

9. analysis of IRBP proteolysis is useful as a biomarker for uveitis

10. Mutations in RBP3 are an infrequent cause of autosomal recessive retinitis pigmentosa.

11. In interphotoreceptor retinoid-binding protein transgenic mice cone dysfunction appears to be caused by abnormal trafficking of cone opsins due to impaired delivery of all-transretinaldehyde chromophore without IRBP.

Cow (Bovine) Retinol Binding Protein 3, Interstitial (RBP3) interaction partners

1. IRBP is able to bind a variety of carotenoids at an affinity comparable to retinoids and with much stronger affinity than any fatty acid tested.

2. In mouse immunization studies Ehrlichia canis amino acid sequence 44-59 is identified as a candidate mimicry epitope for interphotoreceptor retinoid-binding protein (IRBP) 201-216 and is capable of preventing ocular inflammation.

3. KLF15 binds to multiple 9 bp consensus sites in the Rhodospin and IRBP promoters including the CRS-1 and G-rich repressor elements.

4. Localized to interphotoreceptor matrix, where it is available for binding and transport of visual cycle retinoids.