anti-Retinoschisin 1 (RS1) Antibodies

RS1 encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. Additionally we are shipping Retinoschisin 1 Kits (7) and Retinoschisin 1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RS1 6247 O15537
Anti-Mouse RS1 RS1 20147 Q9Z1L4
Anti-Rat RS1 RS1 100125595  
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Top anti-Retinoschisin 1 Antibodies at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample:Porcine Eye lysate; Primary Ab: 1µg/ml Rabbit Anti-Human RS Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) Figure. Western Blot; Sample: Recombinant protein. 100 μg Log in to see 13 to 16 Days
$350.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p) Immunocytochemistry/Immunofluorescence: RS1 Antibody  - Immunohistochemical staining of human duodenum shows cytoplasmic positivity in endocrine cells. Immunohistochemistry-Paraffin: RS1 Antibody  - Staining of retina shows moderate positivity in photoreceptor cells and nerve fibers. 100 μL Log in to see 10 to 13 Days
$491.63
Details
Human Mouse Un-conjugated WB Western Blot analysis of RS1 expression in transfected 293T cell line by RS1 MaxPab polyclonal antibody.<br><br>Lane 1: RS1 transfected lysate(24.64 KDa).<br>Lane 2: Non-transfected lysate.<br> 50 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IF/ICC, IHC, IP, WB Western blot analysis of Pig Eye lysate, using Human RS Antibody (1 µg/ml) and HRP-conjugated Goat Anti-Rabbit antibody (<a href= Western blot analysis of the recombinant protein. 100 μg Log in to see 71 Days
$440.62
Details
Human Rabbit HRP ELISA   100 μg Log in to see 11 to 18 Days
$412.19
Details
Human Rabbit FITC ELISA   100 μg Log in to see 11 to 18 Days
$412.19
Details
Human Rabbit Biotin ELISA   100 μg Log in to see 11 to 18 Days
$412.19
Details
Human Rabbit Un-conjugated ELISA, IHC   100 μg Log in to see 11 to 18 Days
$412.19
Details
Human Rabbit Un-conjugated ELISA   100 μg Log in to see 11 to 18 Days
$412.19
Details
Human Mouse Un-conjugated WB   50 μg Log in to see 11 to 16 Days
$625.43
Details

RS1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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More Antibodies against Retinoschisin 1 Interaction Partners

Human Retinoschisin 1 (RS1) interaction partners

  1. These results establish that extracellular delivery of RS1 rescues the structural and functional deficits in the Rs1h knockout mouse model and that this ex vivo gene therapy approach can inhibit progression of disease.

  2. Taken together, RS1 mutation was found to segregate with retinoschisis phenotype while none of the other identified variations were co-segregating with the systemic defects. Hereby, we infer that the multisystemic defects harbored by the patient are a rare coexistence of XLRS, developmental delay, sensorineural hearing loss, and reduced axial tone reported for the first time in the literature.

  3. Results suggest a regulatory effect of retinoschisin on Na/K-ATPase (show ATP1A1 Antibodies) signaling and localization, whereas Na/K-ATPase (show ATP1A1 Antibodies)-dysregulation caused by retinoschisin deficiency could represent an initial step in XLRS pathogenesis.

  4. these findings support distinct mechanisms of pathology for two classes of X-linked retinoschisis -associated mutations in the retinoschisin assembly.

  5. A novel RS1 (97delT) mutation was identified in a Taiwanese family with X-linked retinoschisis (XLRS). This finding expands the RS1 mutation spectrum and may help to further understand the molecular pathogenesis of XLRS.

  6. A novel RS1 (304C > T) mutation in a Taiwanese family with X-linked retinoschisis.

  7. We identified a novel causative mutation of RS1 in a Chinese family with X-linked juvenile retinoschisis.

  8. the disease and p.Arg197Cys mutation of RS1 gene was identified

  9. Sequencing of the RS1 gene identified 16 mutations, nine of which were novel.

  10. Severe RS1 missense changes were associated with a lower ERG b (show ERG Antibodies)/a ratio than were mild changes in X-linked retinoschisis suggesting the effect of the mutations on protein structure influenced the retinal dysfunction.

Mouse (Murine) Retinoschisin 1 (RS1) interaction partners

  1. Results suggest a regulatory effect of retinoschisin on Na/K-ATPase (show ATP1A1 Antibodies) signaling and localization, whereas Na/K-ATPase (show ATP1A1 Antibodies)-dysregulation caused by retinoschisin deficiency could represent an initial step in XLRS pathogenesis.

  2. retinoschisin is a novel regulator of MAP kinase (show MAPK1 Antibodies) signalling and exerts an anti-apoptotic effect on retinal cells.

  3. Based on this structure, we propose that RS1 couples neighboring membranes together through octamer-octamer contacts, perhaps modulated by interactions with other membrane components.

  4. Changes in Rs1-knockout mice were associated with age related alterations in photoreceptor morphology and transcription factor expression that suggest delayed photoreceptor maturation.

  5. Time line analysis after short-term treatment with dorzolamide failed to show short-, intermediate-, or long-term evidence of structural improvement in Rs1h(-/y) mice.

  6. The results of this study demonstrated that loss of Rs1 gene function has a significant impact on the expression of photoreceptor transcription factor network genes, and morphological and functional defects in young (P21 (show D4S234E Antibodies)) Rs1-KO mice.

  7. RS1 is needed for preservation of synaptic structures but not synaptogenesis in retinoschisis model.

  8. Data suggest that a CpG island enhancer and two CBRs may act in a combinatorial fashion to fine-tune RS1 transcript levels in the retina.

  9. Retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis, membrane association is severely impaired in the absence of ATP1A3 (show ATP1A3 Antibodies) and ATP1B2 (show ATP1B2 Antibodies).

  10. Upon Rs1 adsorption, phosphatidylserine and phosphatidylserine-containing mixed lipid bilayers underwent fast and extensive reorganization.

Retinoschisin 1 (RS1) Antigen Profile

Protein Summary

This gene encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. The encoded protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Mutations in this gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision.

Gene names and symbols associated with anti-Retinoschisin 1 (RS1) Antibodies

  • retinoschisin 1 (RS1) antibody
  • retinoschisin 1 S homeolog (rs1.S) antibody
  • retinoschisin 1 (rs1) antibody
  • retinoschisis (X-linked, juvenile) 1 (human) (Rs1) antibody
  • retinoschisin 1 (Rs1) antibody
  • RS antibody
  • Rs1h antibody
  • tmgc1 antibody
  • Xlrs1 antibody

Protein level used designations for anti-Retinoschisin 1 (RS1) Antibodies

X-linked juvenile retinoschisis protein , retinoschisin , retinoschisis (X-linked, juvenile) 1 , retinoschisin 1 , retinoschisin-like , X-linked juvenile retinoschisis protein homolog , retinoschisis 1 homolog

GENE ID SPECIES
6247 Homo sapiens
491762 Canis lupus familiaris
615193 Bos taurus
748866 Pan troglodytes
779332 Xenopus laevis
100124900 Xenopus (Silurana) tropicalis
100126075 Oryctolagus cuniculus
100127441 Sus scrofa
100423325 Macaca mulatta
20147 Mus musculus
100125595 Rattus norvegicus
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