Rhotekin Proteins (RTKN)

RTKN encodes a scaffold protein that interacts with GTP-bound Rho proteins. Additionally we are shipping Rhotekin Antibodies (50) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RTKN 6242 Q9BST9
RTKN 20166 Q8C6B2
RTKN 297383 Q6V7V2
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Rhotekin Proteins at antibodies-online.com

Showing 8 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human RTKN Protein. 100 μg Log in to see 11 to 18 Days
$369.55
Details
Escherichia coli (E. coli) Rat Un-conjugated SDS-PAGE analysis of Rat RTKN Protein. 100 μg Log in to see 11 to 18 Days
$611.18
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,567.67
Details
Escherichia coli (E. coli) Human GST tag   50 μg Log in to see 6 to 7 Days
$300.81
Details

RTKN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus) ,
,

More Proteins for Rhotekin (RTKN) Interaction Partners

Human Rhotekin (RTKN) interaction partners

  1. Let-7a microRNA inhibits tumor cell growth and metastasis by directly targeting RTKN in human colon cancer.

  2. RTKN is upregulated in hepatocellular carcinoma.MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma.

  3. The RTKN protein is associated with lung cancer in clinic samples and exerts anticancer activity in lung adenocarcinoma cells through inhibiting cell cycle progression and the DNA replication machinery.

  4. RTKN could affect the proliferation and metastasis of colon cancer by reducing expression of MCM2/3/5, CDK1/2 and PCNA

  5. suggest that interaction of S100A4 and Rhotekin permits S100A4 to complex with RhoA and switch Rho function from stress fiber formation to membrane ruffling to confer an invasive phenotypea

  6. Protein kinase D regulates RhoA activity via phosphorylation rhotekin at Ser-435.

  7. Rho/RTKN-mediated NF-kappaB activation leading to cell survival may play a key role in gastric tumorigenesis.

  8. overexpression may play a key role in gastric tumorigenesis by conferring cells resistance to apoptosis

  9. These results suggest that the RTKN gene is involved in bladder carcinogenesis and progression in bladder carcinoma, indicating that RTKN gene could be a molecular target in cancer therapy.

  10. Lin-7B is a binding partner for Rhotekin in the human brain cDNA library

  11. SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling

  12. Rhotekin forms a complex with vinexin and may play a role at focal adhesions.

  13. Loss of miR-145 may provide a selective growth advantage for MCF-7 by targeting RTKN.

Mouse (Murine) Rhotekin (RTKN) interaction partners

  1. these findings suggest that cGK-Ialpha interacts with and phosphorylates rhotekin, thereby contributing to neurite outgrowth regulation.

Rhotekin (RTKN) Protein Profile

Protein Summary

This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with Rhotekin Proteins (RTKN)

  • rhotekin (RTKN)
  • rhotekin (rtkn)
  • rhotekin (Rtkn)
  • RTKN protein

Protein level used designations for Rhotekin Proteins (RTKN)

rhotekin , rhotekin-like

GENE ID SPECIES
459334 Pan troglodytes
100053888 Equus caballus
100124981 Xenopus (Silurana) tropicalis
100349385 Oryctolagus cuniculus
100400941 Callithrix jacchus
100455723 Pongo abelii
100474465 Ailuropoda melanoleuca
100519086 Sus scrofa
6242 Homo sapiens
20166 Mus musculus
297383 Rattus norvegicus
475788 Canis lupus familiaris
539691 Bos taurus
Selected quality suppliers for Rhotekin Proteins (RTKN)
Did you look for something else?