Rhotekin Proteins (RTKN)

RTKN encodes a scaffold protein that interacts with GTP-bound Rho proteins. Additionally we are shipping Rhotekin Antibodies (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RTKN 6242 Q9BST9
RTKN 20166 Q8C6B2
RTKN 297383 Q6V7V2
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Top Rhotekin Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Rat T7 tag,His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 15 to 18 Days

RTKN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for Rhotekin (RTKN) Interaction Partners

Human Rhotekin (RTKN) interaction partners

  1. Let-7a microRNA inhibits tumor cell growth and metastasis by directly targeting RTKN in human colon cancer.

  2. RTKN is upregulated in hepatocellular carcinoma.MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma.

  3. The RTKN protein is associated with lung cancer in clinic samples and exerts anticancer activity in lung adenocarcinoma cells through inhibiting cell cycle progression and the DNA replication machinery.

  4. RTKN could affect the proliferation and metastasis of colon cancer by reducing expression of MCM2 (show MCM2 Proteins)/3/5, CDK1 (show CDK1 Proteins)/2 and PCNA (show PCNA Proteins)

  5. suggest that interaction of S100A4 (show S100A4 Proteins) and Rhotekin permits S100A4 (show S100A4 Proteins) to complex with RhoA (show RHOA Proteins) and switch Rho function from stress fiber formation to membrane ruffling to confer an invasive phenotypea

  6. Protein kinase D (show PRKD1 Proteins) regulates RhoA (show RHOA Proteins) activity via phosphorylation rhotekin at Ser (show SIGLEC1 Proteins)-435.

  7. Rho/RTKN-mediated NF-kappaB (show NFKB1 Proteins) activation leading to cell survival may play a key role in gastric tumorigenesis.

  8. These results suggest that the RTKN gene is involved in bladder carcinogenesis and progression in bladder carcinoma, indicating that RTKN gene could be a molecular target in cancer therapy.

  9. Lin-7B is a binding partner for Rhotekin in the human brain cDNA library

  10. SEPT9 (show SEPT9 Proteins) sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4 (show SEPT4 Proteins)/SEPT11 (show SEPT11 Proteins) and resistance to Rho/Rhotekin-signaling

Mouse (Murine) Rhotekin (RTKN) interaction partners

  1. these findings suggest that cGK (show PRKG1 Proteins)-Ialpha interacts with and phosphorylates rhotekin, thereby contributing to neurite outgrowth regulation.

Rhotekin (RTKN) Protein Profile

Protein Summary

This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with Rhotekin Proteins (RTKN)

  • rhotekin (RTKN)
  • rhotekin (rtkn)
  • rhotekin (Rtkn)
  • RTKN protein

Protein level used designations for Rhotekin Proteins (RTKN)

rhotekin , rhotekin-like

459334 Pan troglodytes
100053888 Equus caballus
100124981 Xenopus (Silurana) tropicalis
100349385 Oryctolagus cuniculus
100400941 Callithrix jacchus
100455723 Pongo abelii
100474465 Ailuropoda melanoleuca
100519086 Sus scrofa
6242 Homo sapiens
20166 Mus musculus
297383 Rattus norvegicus
475788 Canis lupus familiaris
539691 Bos taurus
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