Ribonuclease, RNase A Family, 2 (Liver, Eosinophil-Derived Neurotoxin) (RNASE2) ELISA Kits

Human Ribonuclease, RNase A Family, 2 (Liver, Eosinophil-Derived Neurotoxin) (RNASE2) interaction partners

1. In healthy children, 95th Percentile values ranged from 1519 mg/kg at 0 months to 54.4 mg/kg at 144 months for fecal calprotectin (fCP) and from 9.9 mg/kg at 0 months to 0.2 mg/kg at 144 months for fecal eosinophil-derived neurotoxin (fEDN). There was a significant association between age and fCP concentrations and age and fEDN concentrations and a significant association between fEDN and fCP.

2. EDN serum level could be considered a candidate molecule as a clinical biomarker for evaluating atopic dermatitis activity and a predictor of relapse

3. Serum EDN level may be a useful marker for monitoring persistent airflow limitation in adult patients with asthma who had positive results for house-dust-specific IgE antibodies.

4. increased in feces after the ingestion of enterocolitis-causative foods

5. RNASE2 gene expression was differentially expressed in rheumatoid arthritis patients considering a sequence polymorphism.

6. mRNA levels of eosinophil granule proteins, rather than sputum eosinophil%, may reflect airway hyperresponsiveness and airflow limitation.

7. The antimicrobial protein, RNase 2 exhibits antiviral against respiratory syncytial virus.

8. findings show substantial amounts of EPX/EDN localise in an extra-granular, low equilibrium density compartment of eosinophils

9. A higher level of serum EDN was found specifically in patients with ALS, indicating that EDN may participate in the pathophysiology of Amyotrophic lateral sclerosis.

10. Eosinophil protein X in urine from asymptomatic neonates is a biomarker significantly associated with later development of allergic sensitization, nasal eosinophilia, and eczema during the first 6 years of life

11. atomic resolution structure

12. crystal structure of a post-translationally modified form of eosinophil-derived neurotoxin (EDN) with four extra residues on its N terminus ((-4)EDN) has been solved and refined at atomic resolution (1 A)

13. EDN and ECP are paralogs in human and Old World monkeys.

14. evidence for glycosylphosphatidylinositol (GPI)-anchored neurotoxin on granulocytes

15. data suggest that peripheral blood eosinophils from subjects with untreated asthma have increased inflammatory capacity, as reflected by greater intracellular concentrations of EDN

16. Results reveal the dendritic cell-activating activity of eosinophil-derived neurotoxin and suggest that it is a likely participant of inflammatory and immune responses--an endogenous multifunctional immune alarmin.

17. Results describe the crystal structure of placental ribonuclease inhibitor in complex with eosinophil-derived neurotoxin, and a mutational analysis based on this structure.

18. May possibly be associated with the development of tropical pulmonary eosinophilia.

19. Elevated glycosylated form of EDN in urine is associated with ovarian cancer

20. EGO is a novel ncRNA gene expressed during eosinophil development and is necessary for normal MBP and EDN transcript expression.

Arabidopsis thaliana Ribonuclease, RNase A Family, 2 (Liver, Eosinophil-Derived Neurotoxin) (RNASE2) interaction partners

1. Lack of rRNA recycling in rns2-2 cells triggers a change in carbon flux, which is redirected through the pentose phosphate pathway to produce ribose-5-phosphate for de novo nucleoside synthesis. rRNA or ribosome turnover is thus essential for cellular homeostasis, probably through maintenance of nucleoside levels as part of the salvage pathway.

2. intracellular retention and localization within the vacuole are critical for its cellular function

3. RNS2, a conserved member of the RNase T2 family, is necessary for ribosomal RNA decay.