Ribonuclease H1 Proteins (RNASEH1)

Endonuclease that specifically degrades the RNA of RNA- DNA hybrids.. Additionally we are shipping Ribonuclease H1 Antibodies (22) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RNASEH1 246243 O60930
RNASEH1 19819  
RNASEH1 298933 Q5BK46
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Top Ribonuclease H1 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days

RNASEH1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Ribonuclease H1 (RNASEH1) Interaction Partners

Human Ribonuclease H1 (RNASEH1) interaction partners

  1. In combination with previously published in vivo data, the findings presented here suggest a model, in which R-loop processing by RNase H1 directs origin-specific initiation of DNA replication in human mitochondria.

  2. RNASEH1 gene variants associate with susceptibility/protection to T1 Diabetes in Colombia.

  3. Studies indicate that ribonuclease H1 is essential for mitochondrial DNA replication.

  4. Data show that the catalytic domains of E. coli and human RNase H have nearly identical sequence preferences, which correlate with the efficiency of RNase H-recruiting antisense oligonucleotides.

  5. Data suggest that ribonuclease H1 (RNASEH1) plays important role in replication fork movement by resolving R-loops (RNA-DNA hybrids); RNASEH1 depletion results in accumulation of RNA-DNA hybrids, slowing of replication forks, and increased DNA damage; RNASEH1 appears to contribute to genome stability and preserves telomere integrity.

  6. RPA is a sensor of R loops and a regulator of RNaseH1, extending the versatile role of RPA in suppression of genomic instability.

  7. RNaseH1 maintains regulated levels of telomeric RNA-DNA hybrids at ALT telomeres to trigger homologous recombination without compromising telomere integrity too severely

  8. found that the 3' fragments of target pre-mRNA generated by ASO were almost completely degraded from their 5' ends by nuclear XRN2 after RNase H1-mediated cleavage

  9. Altered RNaseH1 has a reduced capability to remove the RNA from RNA-DNA hybrids leading to impaired mtDNA replication and adult-onset mitochondrial encephalomyopathy.

  10. RNase H1 and protein P32 are involved in mitochondrial pre-rRNA processing

  11. data implicate the H264 side chain in phosphodiester hydrolysis as well as in product release, and are consistent with a proposed model in which the RNAse H1 H264 side chain interacts with a divalent metal ion to support catalysis

  12. On the basis of its nuclear magnetic resonance (NMR) nucleic acid structure, a boranophosphonate-modified, fully R(P) BH(3) DNA/RNA hybrid is predicted not to be a substrate for RNase H1.

  13. The cysteine residues responsible for the redox-dependent activity of RNase H1 were determined by site-directed mutagenesis to involve Cys(147) and Cys(148), producing an inactive enzyme conformation by disulfide bond formation.

  14. Human RNase H1 uses one tryptophan and two lysines to position the enzyme at the 3'-DNA/5'-RNA terminus of the heteroduplex substrate

  15. in human cells RNase H1 is responsible for most of the activity of DNA-like antisense drugs

  16. analysis of catalytic site of human RNase H1 for heteroduplex substrate catalysis

  17. method for enhancing the human RNase H1 activity of chimeric antisense oligonucleotides

  18. THE role substrate structure plays in directing human RNase H1 activity as well as the design of effective antisense oligodeoxyribonucleotides.

  19. Report crystal structures of RNase H1 in complex with RNA/DNA hybrids.

  20. Characterization of full-length enzymes with defective hybrid binding domain indicates that this domain dramatically enhances both the specific activity and processivity of RNase H1.

Mouse (Murine) Ribonuclease H1 (RNASEH1) interaction partners

  1. RNase H1 is necessary for the activity of DNA-like ASOs. During liver regeneration, a clone of hepatocytes that expressed RNase H1 developed and partially restored mitochondrial and liver function.

  2. the essential role of RNase H1 in mitochondrial DNA replication is the removal of primers at the origin of replication

  3. translational organization of RNase H1 allows tight control of expression of RNase H1 in mitochondria, where its excess or absence can lead to cell death, without affecting the expression of the nuclear RNase H1

  4. RNase H1 is involved in generation of mitochondrial DNA

Ribonuclease H1 (RNASEH1) Protein Profile

Protein Summary

Endonuclease that specifically degrades the RNA of RNA- DNA hybrids.

Gene names and symbols associated with Ribonuclease H1 Proteins (RNASEH1)

  • ribonuclease H1 (RNASEH1)
  • ribonuclease H1 (Rnaseh1)
  • ribonuclease H1 (rnh1)
  • ribonuclease H1 S homeolog (rnaseh1.S)
  • ribonuclease H1 (rnaseh1)
  • ribonuclease H1 L homeolog (rnaseh1.L)
  • ribonuclease H1 (AFUA_1G10020)
  • ribonuclease H1 (Tb927.7.4930)
  • ribonuclease HI (APH_RS00510)
  • Ribonuclease H1 (rnh1)
  • 74/9 protein
  • Afu1g10020 protein
  • CG8729 protein
  • Dmel\\CG8729 protein
  • h1rna protein
  • l(2)43F1-5 protein
  • l(2)43Fa protein
  • l(2)k07409 protein
  • l(2)k07624 protein
  • RNase H1 protein
  • rnaseh1 protein
  • RNASEH1P1 protein
  • rnh1 protein
  • rnhl protein
  • Tb07.26A24.40 protein
  • zgc:91971 protein

Protein level used designations for Ribonuclease H1 Proteins (RNASEH1)

RNase H1 , ribonuclease H type II , CG8729-PA , CG8729-PB , RNaseH1 , rnh1-PA , rnh1-PB , ribonuclease H1 pseudogene 1 , ribonuclease H1 , Ribonuclease H1

246243 Homo sapiens
19819 Mus musculus
35746 Drosophila melanogaster
298933 Rattus norvegicus
395848 Gallus gallus
414644 Xenopus laevis
436932 Danio rerio
475648 Canis lupus familiaris
613354 Bos taurus
707122 Macaca mulatta
735129 Xenopus laevis
743012 Pan troglodytes
3510641 Aspergillus fumigatus Af293
3658705 Trypanosoma brucei brucei strain 927/4 GUTat10.1
3930711 Anaplasma phagocytophilum str. HZ
100124876 Xenopus (Silurana) tropicalis
100196582 Salmo salar
100305327 Oncorhynchus mykiss
100725358 Cavia porcellus
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