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Results show that a low expression of RNH1 in metastasis of bladder cancer and suggest that it might regulate the function of ILK through mutual binding.
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Data suggest that ribonuclease inhibitor (RNH1) protects HeLa cells from ribonuclease 1 (RNase 1).
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a novel mechanism of ANG in regulating PI3K/AKT/mTOR signaling pathway via RI, is reported.
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RNH1 bound to RNase 7 and suppressed its antimicrobial activity by blocking its ability to bind the cell wall of uropathogenic bacteria.
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angiogenin and ILK signaling pathway plays a pivotal role in mediating the inhibitory effects of RI on melanoma cells growth
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RI could play a novel role in inhibiting metastasis of bladder cancer through regulating EMT and ILK signaling pathways.
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RNH1 as a regulator of HDACi resistance in gastric cancer
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RI might play a novel role in the development of bladder cancer through regulating EMT and the ILK signaling pathway.
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PTEN-mediated miR-21 regulation is achieved by inhibiting the interaction between the Drosha complex and RNH1, revealing previously unidentified role of PTEN in the oncogenic miR-21 biogenesis
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the anti-tumor effect of RNH1 is also involved in suppressing growth and metastasis
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RNH1 (as a recombinant fusion protein) is localized to mitochondria, nuclei, and cytosol in HeLa and HCT cells; RNH1 appears to bind to various mitochondrial proteins.
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This protein has been found differentially expressed in the anterior cingulate cortex in men patients with schizophrenia.
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Human ribonuclease inhibitor gene has antiangiogenic and antitumor effects when expressed in hematopoietic cells in mouse melanoma models.
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Results describe the crystal structure of placental ribonuclease inhibitor in complex with eosinophil-derived neurotoxin, and a mutational analysis based on this structure.
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Structural and energetic aspects of the interaction between human RI (hRI) and human pancreatic ribonuclease (RNase 1), is reported.
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The conformational and oxidative stabilities of both RIs increase upon complex formation with ribonucleases. Thus, RI has evolved to maintain its inhibition of invading ribonucleases, even when confronted with extreme environmental stress.
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This the first measurement of the inhibition of the ribonucleolytic activity of onconase by ribonuclease inhibitor protein.
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This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia.
