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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
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these data indicate that RPS13 could promote the growth and cell cycle progression of gastric cancer cells at least through inhibiting p27(kip1 (show CDKN1B Proteins)) expression.
binding of ribosomal protein S13 to 18S rRNA is provided mainly by conserved motifs of the protein corresponding to those motifs in its eubacterial homologue that are involved in the interaction with 16S rRNA in the 30S subunit.
S13 subunit may possess multiple functions, including a deubiquitinylating activity and distinct activities essential for cell cycle progression that require the conserved C120 residue
either RPS13 or RPL23 (show RPL17 Proteins) can promote MDR in gastric cancer cells by suppressing drug-induced apoptosis, and RPL23 (show RPL17 Proteins) may also promote MDR in gastric cancer cells through regulation of glutathione S-transferase (show GSTa2 Proteins)-mediated drug-detoxifying system
Recombinant ribosomal protein S13 expressed in and isolated from E.coli was shown to be suitable for structural and functional investigations.
Overproduction of rpS13 in mammalian cells interferes with splicing of its own pre-mRNA by a feedback mechanism.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
40S ribosomal protein S13
, cytoplasmatic ribosomal protein S13
, ribosomal protein S13
, LOW QUALITY PROTEIN: 40S ribosomal protein S13
, ribosomal protein S13 L homeolog