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Direct regulator of SIRT1. Additionally we are shipping RPS19BP1 Proteins (7) and RPS19BP1 Kits (4) and many more products for this protein.
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AROS is a significant biomarker for tumor aggressiveness in non-cirrhotic hepatocellular carcinoma.
In vitro SIRT1 activity assays disclose AROS as an inhibitor of SIRT1.
study demonstrated a cancer-specific role for AROS in the regulation of survival in a panel of human cell lines; data suggest that AROS, as well as SIRT1, promotes survival in cancer cells while being redundant for viability in non-cancer cells
This study analyses Sirt1 modulation by several putative Sirt1 regulators, showing that the regulator protein AROS has an unusual conformation and that the Sirt1 catalytic domain is sufficient for modulation by resveratrol.
we found that the SIRT1 modulators AROS and DBC1 have an impact on hsp70 transcription, HSF1 acetylation status, and HSF1 recruitment to the hsp70 promoter.
Active regulator of SIRT1 (AROS) is the first direct SIRT1 regulator to be identified that modulates p53-mediated growth regulation.
Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (By similarity).
40S ribosomal protein S19-binding protein 1
, RPS19-binding protein 1
, active regulator of SIRT1
, homolog of mouse S19 binding protein
, S19 binding protein