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E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Additionally we are shipping RNF146 Antibodies (28) and many more products for this protein.
Showing 10 out of 12 products:
Human RNF146 Protein expressed in Escherichia coli (E. coli) - ABIN1741735
Zhang, Liu, Mickanin, Feng, Charlat, Michaud, Schirle, Shi, Hild, Bauer, Myer, Finan, Porter, Huang, Cong: RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. in Nature cell biology 2011
Show all 7 Pubmed References
Human RNF146 Protein expressed in Escherichia coli (E. coli) - ABIN1741734
Kang, Lee, Shin, Andrabi, Chi, Gagné, Lee, Ko, Lee, Poirier, Dawson, Dawson: Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage. in Proceedings of the National Academy of Sciences of the United States of America 2011
Show all 7 Pubmed References
RNF146 exerted oncogenic role through ubiquitination of Axin1 to activate beta-catenin signaling.
Iduna expression under disruptive neurohomeostasis (e.g., uncompensated oxidative stress or ischemic stroke after MCAo) is upregulated by neuroprotectin D1 and thus serves as a key regulator of cell survival, halting neural cell death.
the maintenance of unliganded RNF146 in an inactive state may serve to maintain the stability of the RNF146-TNKS complex, which in turn regulates the homeostasis of PARylation-dependent ubiquitination activity in the cell
RNF146 regulated the development and progression of NSCLC
Iduna is a Poly(ADP-ribose)-dependent ubiquitin E3 ligase.
RNF146/Iduna has been found to be implicated in neurodegenerative disease and cancer development. [Review]
the RNF146 WWE domain recognizes poly(ADP-ribose) (PAR) by interacting with iso-ADP-ribose (iso-ADPR), the smallest internal PAR structural unit containing the characteristic ribose-ribose glycosidic bond formed during poly(ADP-ribosyl)ation.
RNF146 RING-type ubiquitin E3 ligase as a positive regulator of Wnt signaling that operates with tankyrase to maintain low steady-state levels of Axin proteins
Dactylidin may function early in the progression of Alzheimer's disease.
Mutations in the coding regions of the RNF146 and ECHDC1 genes do not contribute to the burden of inherited predisposition of breast cancer in Ashkenazi high risk women.
These findings indicate that RNF146 is required to coordinate beta-catenin signaling within the osteoblast lineage during embryonic and postnatal bone development
RANKL represses the transcription of the E3 ubiquitin ligase RNF146 through an NF-kappaB-related inhibitory element in the RNF146 promoter.
a new function of RNF146 and tankyrase in stabilizing the Crumbs complex through downregulation of AMOT proteins at the apical membrane, is reported.
Modulation of PARP-1-mediated oxidative cell injury by ring finger protein 146 (RNF146) in cardiac myocytes
Iduna acts as a potential antioxidant by improving mitochondrial function and inhibiting oxidative stress-induced parthanatos, and these protective effects are dependent on the involvement of ubiquitin-proteasome system.
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP- ribosylated proteins (By similarity).
, E3 ubiquitin-protein ligase RNF146
, E3 ubiquitin-protein ligase RNF146-B
, RING finger protein 146-B
, E3 ubiquitin-protein ligase rnf146