anti-Ring Finger Protein 2 (RNF2) Antibodies

Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. Additionally we are shipping RNF2 Proteins (7) and RNF2 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RNF2 6045 Q99496
RNF2 19821 Q9CQJ4
RNF2 304850 Q4KLY4
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Top anti-RNF2 Antibodies at antibodies-online.com

Showing 10 out of 64 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-RNF2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Daudi cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ChIPSeq, ChIP, ICC, IF, IP, WB Ring1B antibody (mAb) tested by ChIP-chip. ChIP was performed using the ChIP-IT® High Sensitivity Kit (Cat. No. 53040) with chromatin from 4.5 million human embryonic stem cells and 4 µl of antibody. ChIP DNA was amplified by WGA, labeled and hybridized to a human tiling array. The two images show regions of strong binding on chromosomes 2 and 9. 100 μg Log in to see 1 to 2 Days
$507.50
Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-RNF2 Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated WB Western Blot analysis of RNF2 expression in transfected 293T cell line by RNF2 monoclonal antibody (M01), clone 6C2. Lane 1: RNF2 transfected lysate(37.7 KDa). Lane 2: Non-transfected lysate. Western blot analysis of RNF2 over-expressed 293 cell line, cotransfected with RNF2 Validated Chimera RNAi used as specificity and loading control. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Goat Un-conjugated ELISA, WB ABIN184925 staining (0.5 µg/ml) of K562 lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Mouse Un-conjugated WB RNF2 monoclonal antibody (M14), clone 2B4. Western Blot analysis of RNF2 expression in A-549. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), IP, WB Western Blot: RNF2 Antibody [NBP1-49966] - Detection of Human and Mouse RNF2 by Western Blot (h&m) and Immunoprecipitation (h). Samples: Whole cell lysate from K562 (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 mcg), and mouse NIH3T3 (M; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-RNF2 antibody used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. RNF2 was also immunoprecipitated by rabbit anti-RNF2 antibody, which recognizes a downstream epitope. For blotting immunoprecipitated RNF2 was used. Detection: Chemiluminescence with exposure times of 30 seconds (A and B). Immunohistochemistry-Paraffin: RNF2 Antibody [NBP1-49966] - Human prostate carcinoma. Antibody used at a dilution of 1:1,000. 100 μL Log in to see 7 to 9 Days
$556.31
Details
Human Mouse Un-conjugated IF, ELISA, WB RNF2 monoclonal antibody (M06), clone 4A9. Western Blot analysis of RNF2 expression in Hela S3 NE . RNF2 monoclonal antibody (M06), clone 4A9. Western Blot analysis of RNF2 expression in human placenta. 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated ChIP, IF, IHC, IP, WB 100 μL Log in to see 16 Days
$334.02
Details
Human Mouse Un-conjugated RNAi, ELISA, WB RNF2 monoclonal antibody (M01), clone 6C2 Western Blot analysis of RNF2 expression in NIH/3T3 . Western blot analysis of RNF2 over-expressed 293 cell line, cotransfected with RNF2 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with RNF2 monoclonal antibody (M01), clone 6C2. GAPDH ( 36.1 kDa ) used as specificity and loading control. 100 μg Log in to see 11 to 12 Days
$440.00
Details

RNF2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine)
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Rat (Rattus)
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Top referenced anti-RNF2 Antibodies

  1. Human Monoclonal RNF2 Primary Antibody for ChIPSeq, ChIP - ABIN2668629 : Basu, Wilkinson, Colavita, Fennelly, Atchison: YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment. in Nucleic acids research 2014 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal RNF2 Primary Antibody for RNAi, ELISA - ABIN562662 : Ohtsubo, Yasunaga, Ohno, Tsumura, Okada, Ishikawa, Shirao, Kikuchi, Nishitani, Kobayashi, Takihara: Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal RNF2 Primary Antibody for IHC, IHC (p) - ABIN4350772 : Holdt, Hoffmann, Sass, Langenberger, Scholz, Krohn, Finstermeier, Stahringer, Wilfert, Beutner, Gielen, Schuler, Gäbel, Bergert, Bechmann, Stadler, Thiery, Teupser: Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. in PLoS genetics 2013 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal RNF2 Primary Antibody for ELISA, WB - ABIN268569 : Tuckfield, Clouston, Wilanowski, Zhao, Cunningham, Jane: Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors. in Molecular and cellular biology 2002 (PubMed)

More Antibodies against RNF2 Interaction Partners

Zebrafish Ring Finger Protein 2 (RNF2) interaction partners

  1. The polycomb group protein (show CBX4 Antibodies) ring1b/rnf2 is specifically required for craniofacial development.

  2. These results reveal that, in the absence of functional Ring1b, fin bud cells fail to execute the pectoral fin developmental program.

Human Ring Finger Protein 2 (RNF2) interaction partners

  1. These data suggest that RNF2 is an important upstream negative regulator of SIK1 (show SIK1 Antibodies) and that restoration of SIK1 (show SIK1 Antibodies) levels induced by loss of RNF2 inhibited HCC (show FAM126A Antibodies) cell growth and promoted apoptosis, which may represent a promising therapeutic strategy for HCC (show FAM126A Antibodies) treatment.

  2. Study found that prostate cancer (PCa (show FLVCR1 Antibodies)) tissues have high RNF2 expression which is positively correlated with tumor grade indicating that RNF2 may have oncogenic function in PCa (show FLVCR1 Antibodies).

  3. Our findings identify RING1B as a trait of the cell-of-origin in Ewing sarcoma

  4. Study detected RNF2 expression to be overexpressed in esophageal carcinoma cell lines and was associated with the poor prognosis of esophageal carcinoma patients. Data also reflect its important role in the growth of esophageal carcinoma cells by shRNA silencing of RNF2 expression.

  5. overexpression of RNF2, as examined by immunohistochemical analysis, might serve as a novel prognostic biomarker and potential therapeutic target for urothelial carcinoma of the bladder patients.

  6. Our findings support the notion that epigenetic regulators, such as RNF2, directly and functionally control powerful gene networks that are vital in multiple cancer processes.

  7. O-GlcNAc (show OGT Antibodies) modifies and regulates an essential epigenetic tool, RING1B, which may contribute to human embryonic stem cells pluripotency maintenance and differentiation.

  8. The enzymatic activity of BMI1 (show BMI1 Antibodies) and RING1B were evaluated and compared.

  9. Bmi1 (show BMI1 Antibodies) and possibly RNF2 may be attractive biomarkers of gemcitabine resistance in the context of RRM1 (show RRM1 Antibodies) expression.

  10. combinatorial silencing along with Ezh2 (show EZH2 Antibodies) depleted epigenetically modified H2- and H3-histones and inhibited pancreatic cancer cell growth in vitro and in vivo (xenograft model)

Mouse (Murine) Ring Finger Protein 2 (RNF2) interaction partners

  1. Data show that RNF2 promotes STAT1 (show STAT1 Antibodies)/STAT2 (show STAT2 Antibodies) disassociation from DNA.

  2. the ability of RING1B, a core component of PRC1 (show PRC1 Antibodies), to ubiquitinate histone H2A is dispensable for early mouse embryonic development and much of the gene repression activity of PRC1 (show PRC1 Antibodies)

  3. RNF2 associates with AMBRA1 (show AMBRA1 Antibodies) to act as an E3 ligase to ubiquitinate AMBRA1 (show AMBRA1 Antibodies) via K48 linkage.

  4. The polycomb (show CBX2 Antibodies) component Ring1B regulates the timed termination of Fezf2 (show FEZF2 Antibodies) expression and thus subcerebral projection neuron production during mouse neocortical development.

  5. Expansion of hepatic stem/progenitor cells requires Ring1B-mediated epigenetic silencing of Cdkn1a (show CDKN1A Antibodies) and Cdkn2a, demonstrating that Ring1B simultaneously regulates multiple CDKIs in tissue stem/progenitor cells.

  6. Af9 (show MLLT3 Antibodies) mediates site-selective physical and functional recruitment of Rnf2 to the alpha-ENaC (show SCNN1A Antibodies) promoter to constrain basal alpha-ENaC (show SCNN1A Antibodies) transcription in collecting duct cells.

  7. Ring1b mediates Meis2 (show MEIS2 Antibodies) promoter and midbrain-specific enhancer association.

  8. Aurora B (show AURKC Antibodies) and Ring1B co-occupy active promoters in resting lymphocytes.

  9. Fbxl10 (show KDM2B Antibodies) has a key role in regulating Ring1B recruitment to its target genes and H2AK119 ubiquitylation in embryonic stem cells.

  10. identification of gene-dosage-dependent roles in primordial germ cell development for Ring1 (show RING1 Antibodies) and Rnf2, two central components of the Polycomb (show CBX2 Antibodies) repressive complex 1 (PRC1 (show PRC1 Antibodies))

RNF2 Antigen Profile

Protein Summary

Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.

Gene names and symbols associated with RNF2

  • ring finger protein 2 (rnf2) antibody
  • ring finger protein 2 (RNF2) antibody
  • ring finger protein 2 (Rnf2) antibody
  • ring finger protein 2 L homeolog (rnf2.L) antibody
  • AI326319 antibody
  • AI450156 antibody
  • AU019207 antibody
  • bap-1 antibody
  • bap1 antibody
  • ding antibody
  • fa19h05 antibody
  • hipi3 antibody
  • Ring1B antibody
  • ring2 antibody
  • wu:fa19h05 antibody
  • wz4556 antibody

Protein level used designations for RNF2

E3 ubiquitin-protein ligase RING2 , ring finger protein 1b , wz4566 , RING finger protein 1B , HIP2-interacting protein 3 , RING finger protein BAP-1 , huntingtin-interacting protein 2-interacting protein 3 , protein DinG , RING1b

GENE ID SPECIES
327035 Danio rerio
424452 Gallus gallus
457581 Pan troglodytes
100174504 Pongo abelii
6045 Homo sapiens
480042 Canis lupus familiaris
540090 Bos taurus
19821 Mus musculus
304850 Rattus norvegicus
100127274 Xenopus laevis
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