anti-Ring Finger Protein 2 (RNF2) Antibodies

Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. Additionally we are shipping RNF2 Proteins (7) and RNF2 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RNF2 6045 Q99496
RNF2 19821 Q9CQJ4
RNF2 304850 Q4KLY4
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-RNF2 Antibodies at antibodies-online.com

Showing 10 out of 90 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RNF2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Daudi cell lysate RNF2 is supported by BioGPS gene expression data to be expressed in Daudi WB Suggested Anti-RNF2 antibody Titration: 1 ug/mL Sample Type: Human Heart 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-RNF2 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate Human kidney 100 μL 2 to 3 Days
$229.00
Details
Human Goat Un-conjugated ELISA, WB ABIN184925 staining (0.5 µg/ml) of K562 lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Human Mouse Un-conjugated ELISA, WB 100 μg 11 to 14 Days
$551.83
Details
Human Mouse Un-conjugated ELISA, WB 100 μg 11 to 14 Days
$551.83
Details
Human Mouse Un-conjugated IF, ELISA, WB RNF2 monoclonal antibody (M08), clone 3B8. Western Blot analysis of RNF2 expression in Hela S3 NE . RNF2 monoclonal antibody (M08), clone 3B8. Western Blot analysis of RNF2 expression in human placenta. 100 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated ChIP, IF, IHC, IP, WB 100 μL 11 to 13 Days
$366.77
Details
Human Mouse Un-conjugated RNAi, ELISA, WB RNF2 monoclonal antibody (M01), clone 6C2 Western Blot analysis of RNF2 expression in NIH/3T3 . Western blot analysis of RNF2 over-expressed 293 cell line, cotransfected with RNF2 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with RNF2 monoclonal antibody (M01), clone 6C2. GAPDH ( 36.1 kDa ) used as specificity and loading control. 100 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of RING2/RING1B/RNF2 expression in rat brain extract (lane 1), and HELA whole cell lysates (lane 2). RING2/RING1B/RNF2 at 38KD was detected using rabbit anti- RING2/RING1B/RNF2 Antigen Affinity purified polyclonal antibody at0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method RING2/RING1B/RNF2 was detected in paraffin-embedded sections of human mammary cancer tissues using rabbit anti- RING2/RING1B/RNF2 Antigen Affinity purified polyclonal antibody at 1 μg/mL. The immunohistochemical section was developed using SABC method 100 μg 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated WB WB Image Sample(30 μg of whole cell lysate) A:MOLT4, 12% SDS PAGE antibody diluted at 1:500 100 μL 3 to 4 Days
$466.18
Details

Top referenced anti-RNF2 Antibodies

  1. Human Monoclonal RNF2 Primary Antibody for ChIP-seq, ChIP - ABIN2668629 : Basu, Wilkinson, Colavita, Fennelly, Atchison: YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment. in Nucleic acids research 2014 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal RNF2 Primary Antibody for RNAi, ELISA - ABIN562662 : Ohtsubo, Yasunaga, Ohno, Tsumura, Okada, Ishikawa, Shirao, Kikuchi, Nishitani, Kobayashi, Takihara: Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal RNF2 Primary Antibody for IHC, IHC (p) - ABIN4350772 : Holdt, Hoffmann, Sass, Langenberger, Scholz, Krohn, Finstermeier, Stahringer, Wilfert, Beutner, Gielen, Schuler, Gäbel, Bergert, Bechmann, Stadler, Thiery, Teupser: Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. in PLoS genetics 2013 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal RNF2 Primary Antibody for ELISA, WB - ABIN268569 : Tuckfield, Clouston, Wilanowski, Zhao, Cunningham, Jane: Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors. in Molecular and cellular biology 2002 (PubMed)

More Antibodies against RNF2 Interaction Partners

Human Ring Finger Protein 2 (RNF2) interaction partners

  1. resultant reduction of UBE3A protein level alleviates its effect on ubiquitination-mediated degradation of Ring1B

  2. MiR-139-5p overexpression combined with inactivation of the MAPK signaling pathway can reverse the cisplatin resistance of OC by suppressing RNF2.

  3. The ubiquitin ligase and PRC1 component RNF2/Ring1B is required to support DNA replication.

  4. Study shows that concomitant recruitment of RING1B to active enhancers occurs across multiple cancers, highlighting an under-explored function of cPRC1 in regulating oncogenic transcriptional programs in cancer.

  5. these data indicate that RING1B and EZH2 repress the innate inflammatory cutaneous squamous cell carcinoma function and impair tumor immunosurveillance

  6. Observations demonstrated that Plk1 directly interacts with RNF2 and degrades RNF2 via the ubiquitindependent degradation pathway. RNF2 may be used as a new target for mitotic regulation and tumorigenesis.

  7. These data suggest that RNF2 is an important upstream negative regulator of SIK1 and that restoration of SIK1 levels induced by loss of RNF2 inhibited HCC cell growth and promoted apoptosis, which may represent a promising therapeutic strategy for HCC treatment.

  8. Study found that prostate cancer (PCa) tissues have high RNF2 expression which is positively correlated with tumor grade indicating that RNF2 may have oncogenic function in PCa.

  9. Our findings identify RING1B as a trait of the cell-of-origin in Ewing sarcoma

  10. Study detected RNF2 expression to be overexpressed in esophageal carcinoma cell lines and was associated with the poor prognosis of esophageal carcinoma patients. Data also reflect its important role in the growth of esophageal carcinoma cells by shRNA silencing of RNF2 expression.

  11. overexpression of RNF2, as examined by immunohistochemical analysis, might serve as a novel prognostic biomarker and potential therapeutic target for urothelial carcinoma of the bladder patients.

  12. Our findings support the notion that epigenetic regulators, such as RNF2, directly and functionally control powerful gene networks that are vital in multiple cancer processes.

  13. O-GlcNAc modifies and regulates an essential epigenetic tool, RING1B, which may contribute to human embryonic stem cells pluripotency maintenance and differentiation.

  14. The enzymatic activity of BMI1 and RING1B were evaluated and compared.

  15. Bmi1 and possibly RNF2 may be attractive biomarkers of gemcitabine resistance in the context of RRM1 expression.

  16. combinatorial silencing along with Ezh2 depleted epigenetically modified H2- and H3-histones and inhibited pancreatic cancer cell growth in vitro and in vivo (xenograft model)

  17. BAP1 deficiency causes increased expression of FoxK2 target genes in a Ring1B-Bmi1-dependent manner

  18. Authors describe a critical role for the polycomb group protein Ring1b in nonhomologous end-joining (NHEJ)-mediated end-to-end chromosome fusions.

  19. we identify p63 as a target of Ring1B to regulate Fak expression in breast cancer epithelial cells

  20. Ring1B and the SNAG-associated chromatin modifier EZH2 formed distinct protein complexes with Snail and that EZH2 was required for Snail-Ring1A/B recruitment to the target promoter.

Mouse (Murine) Ring Finger Protein 2 (RNF2) interaction partners

  1. Functional associations among DNA, transcription, and chromatin over PcG-repressed genes can be regulated by the formation of R-loops and that RING1B may play a vital role in this pathway for transcriptional repression.

  2. Ring1A/B regulate and maintain AML stem cells in part by repressing Glis2 expression, which promotes their differentiation.

  3. Data show that RNF2 promotes STAT1/STAT2 disassociation from DNA.

  4. the ability of RING1B, a core component of PRC1, to ubiquitinate histone H2A is dispensable for early mouse embryonic development and much of the gene repression activity of PRC1

  5. RNF2 associates with AMBRA1 to act as an E3 ligase to ubiquitinate AMBRA1 via K48 linkage.

  6. The polycomb component Ring1B regulates the timed termination of Fezf2 expression and thus subcerebral projection neuron production during mouse neocortical development.

  7. Expansion of hepatic stem/progenitor cells requires Ring1B-mediated epigenetic silencing of Cdkn1a and Cdkn2a, demonstrating that Ring1B simultaneously regulates multiple CDKIs in tissue stem/progenitor cells.

  8. Af9 mediates site-selective physical and functional recruitment of Rnf2 to the alpha-ENaC promoter to constrain basal alpha-ENaC transcription in collecting duct cells.

  9. Ring1b mediates Meis2 promoter and midbrain-specific enhancer association.

  10. Aurora B and Ring1B co-occupy active promoters in resting lymphocytes.

  11. Fbxl10 has a key role in regulating Ring1B recruitment to its target genes and H2AK119 ubiquitylation in embryonic stem cells.

  12. identification of gene-dosage-dependent roles in primordial germ cell development for Ring1 and Rnf2, two central components of the Polycomb repressive complex 1 (PRC1)

  13. Ring1b inactivation in differentiated islet beta cells (Ring1b(betaKO)) did not cause derepression, even after multiple rounds of cell division, suggesting a role for Ring1b in the establishment but not the maintenance of repression

  14. loss of Ring1a/b postnatally results in defective cervical loops and disturbances of enamel and dentin formation in continuously growing incisors

  15. It was shown that Ring1B interacted with multiple complexes in embryonic stem cells. Although H2A.Z co-localized with Eed, Ring1B and CpG islands in chromatin, H2A.Z still blanketed polycomb target loci in the absence of Suz12, Eed, or Ring1B.

  16. Data provide a valuable basis for future investigations aimed at eukaryotic DING proteins, revealing that these proteins seem ubiquitous in mouse tissue.

  17. Ring1B and Suv39h1 have mutually exclusive roles in regulating distinct chromatin states at key developmental genes, and play a part in how lineage specification can be reinforced during early development

  18. Ring1B-mediated chromatin compaction acts to directly limit transcription in embryonic stem cells.

  19. polycomb protein Ring1B regulation by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome

  20. Involved in the specification of the anterior-posterior axis in mice

Zebrafish Ring Finger Protein 2 (RNF2) interaction partners

  1. The polycomb group protein ring1b/rnf2 is specifically required for craniofacial development.

  2. These results reveal that, in the absence of functional Ring1b, fin bud cells fail to execute the pectoral fin developmental program.

RNF2 Antigen Profile

Protein Summary

Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.

Gene names and symbols associated with RNF2

  • ring finger protein 2 (RNF2) antibody
  • ring finger protein 2 (Rnf2) antibody
  • ring finger protein 2 (rnf2) antibody
  • ring finger protein 2 L homeolog (rnf2.L) antibody
  • AI326319 antibody
  • AI450156 antibody
  • AU019207 antibody
  • bap-1 antibody
  • bap1 antibody
  • ding antibody
  • fa19h05 antibody
  • hipi3 antibody
  • ring1b antibody
  • ring2 antibody
  • wu:fa19h05 antibody
  • wz4556 antibody

Protein level used designations for RNF2

E3 ubiquitin-protein ligase RING2 , HIP2-interacting protein 3 , RING finger protein 1B , RING finger protein BAP-1 , huntingtin-interacting protein 2-interacting protein 3 , protein DinG , RING1b , ring finger protein 1b , wz4566

GENE ID SPECIES
6045 Homo sapiens
19821 Mus musculus
304850 Rattus norvegicus
327035 Danio rerio
100127274 Xenopus laevis
424452 Gallus gallus
457581 Pan troglodytes
100174504 Pongo abelii
480042 Canis lupus familiaris
540090 Bos taurus
100717673 Cavia porcellus
100344273 Oryctolagus cuniculus
Selected quality suppliers for anti-RNF2 (RNF2) Antibodies
Did you look for something else?