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Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation.
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Human Monoclonal RNF2 Primary Antibody for ChIPSeq, ChIP - ABIN2668629
Basu, Wilkinson, Colavita, Fennelly, Atchison: YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment. in Nucleic acids research 2014
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Human Monoclonal RNF2 Primary Antibody for RNAi, ELISA - ABIN562662
Ohtsubo, Yasunaga, Ohno, Tsumura, Okada, Ishikawa, Shirao, Kikuchi, Nishitani, Kobayashi, Takihara: Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity. in Proceedings of the National Academy of Sciences of the United States of America 2008
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Human Polyclonal RNF2 Primary Antibody for IHC, IHC (p) - ABIN4350772
Holdt, Hoffmann, Sass, Langenberger, Scholz, Krohn, Finstermeier, Stahringer, Wilfert, Beutner, Gielen, Schuler, Gäbel, Bergert, Bechmann, Stadler, Thiery, Teupser: Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. in PLoS genetics 2013
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Human Polyclonal RNF2 Primary Antibody for ELISA, WB - ABIN268569
Tuckfield, Clouston, Wilanowski, Zhao, Cunningham, Jane: Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors. in Molecular and cellular biology 2002
The polycomb group protein (show CBX4 Antibodies) ring1b/rnf2 is specifically required for craniofacial development.
These results reveal that, in the absence of functional Ring1b, fin bud cells fail to execute the pectoral fin developmental program.
These data suggest that RNF2 is an important upstream negative regulator of SIK1 (show SIK1 Antibodies) and that restoration of SIK1 (show SIK1 Antibodies) levels induced by loss of RNF2 inhibited HCC (show FAM126A Antibodies) cell growth and promoted apoptosis, which may represent a promising therapeutic strategy for HCC (show FAM126A Antibodies) treatment.
Study found that prostate cancer (PCa (show FLVCR1 Antibodies)) tissues have high RNF2 expression which is positively correlated with tumor grade indicating that RNF2 may have oncogenic function in PCa (show FLVCR1 Antibodies).
Our findings identify RING1B as a trait of the cell-of-origin in Ewing sarcoma
Study detected RNF2 expression to be overexpressed in esophageal carcinoma cell lines and was associated with the poor prognosis of esophageal carcinoma patients. Data also reflect its important role in the growth of esophageal carcinoma cells by shRNA silencing of RNF2 expression.
overexpression of RNF2, as examined by immunohistochemical analysis, might serve as a novel prognostic biomarker and potential therapeutic target for urothelial carcinoma of the bladder patients.
Our findings support the notion that epigenetic regulators, such as RNF2, directly and functionally control powerful gene networks that are vital in multiple cancer processes.
O-GlcNAc (show OGT Antibodies) modifies and regulates an essential epigenetic tool, RING1B, which may contribute to human embryonic stem cells pluripotency maintenance and differentiation.
The enzymatic activity of BMI1 (show BMI1 Antibodies) and RING1B were evaluated and compared.
Bmi1 (show BMI1 Antibodies) and possibly RNF2 may be attractive biomarkers of gemcitabine resistance in the context of RRM1 (show RRM1 Antibodies) expression.
combinatorial silencing along with Ezh2 (show EZH2 Antibodies) depleted epigenetically modified H2- and H3-histones and inhibited pancreatic cancer cell growth in vitro and in vivo (xenograft model)
Data show that RNF2 promotes STAT1 (show STAT1 Antibodies)/STAT2 (show STAT2 Antibodies) disassociation from DNA.
the ability of RING1B, a core component of PRC1 (show PRC1 Antibodies), to ubiquitinate histone H2A is dispensable for early mouse embryonic development and much of the gene repression activity of PRC1 (show PRC1 Antibodies)
RNF2 associates with AMBRA1 (show AMBRA1 Antibodies) to act as an E3 ligase to ubiquitinate AMBRA1 (show AMBRA1 Antibodies) via K48 linkage.
The polycomb (show CBX2 Antibodies) component Ring1B regulates the timed termination of Fezf2 (show FEZF2 Antibodies) expression and thus subcerebral projection neuron production during mouse neocortical development.
Expansion of hepatic stem/progenitor cells requires Ring1B-mediated epigenetic silencing of Cdkn1a (show CDKN1A Antibodies) and Cdkn2a, demonstrating that Ring1B simultaneously regulates multiple CDKIs in tissue stem/progenitor cells.
Af9 (show MLLT3 Antibodies) mediates site-selective physical and functional recruitment of Rnf2 to the alpha-ENaC (show SCNN1A Antibodies) promoter to constrain basal alpha-ENaC (show SCNN1A Antibodies) transcription in collecting duct cells.
Ring1b mediates Meis2 (show MEIS2 Antibodies) promoter and midbrain-specific enhancer association.
Aurora B (show AURKC Antibodies) and Ring1B co-occupy active promoters in resting lymphocytes.
Fbxl10 (show KDM2B Antibodies) has a key role in regulating Ring1B recruitment to its target genes and H2AK119 ubiquitylation in embryonic stem cells.
identification of gene-dosage-dependent roles in primordial germ cell development for Ring1 (show RING1 Antibodies) and Rnf2, two central components of the Polycomb (show CBX2 Antibodies) repressive complex 1 (PRC1 (show PRC1 Antibodies))
Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.
E3 ubiquitin-protein ligase RING2
, ring finger protein 1b
, RING finger protein 1B
, HIP2-interacting protein 3
, RING finger protein BAP-1
, huntingtin-interacting protein 2-interacting protein 3
, protein DinG