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Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. Additionally we are shipping RNF2 Antibodies (90) and RNF2 Proteins (7) and many more products for this protein.
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these data indicate that RING1B and EZH2 (show EZH2 ELISA Kits) repress the innate inflammatory cutaneous squamous cell carcinoma function and impair tumor immunosurveillance
Observations demonstrated that Plk1 (show PLK1 ELISA Kits) directly interacts with RNF2 and degrades RNF2 via the ubiquitindependent degradation pathway. RNF2 may be used as a new target for mitotic regulation and tumorigenesis.
These data suggest that RNF2 is an important upstream negative regulator of SIK1 and that restoration of SIK1 levels induced by loss of RNF2 inhibited HCC cell growth and promoted apoptosis, which may represent a promising therapeutic strategy for HCC treatment.
Study found that prostate cancer (PCa) tissues have high RNF2 expression which is positively correlated with tumor grade indicating that RNF2 may have oncogenic function in PCa.
Our findings identify RING1B as a trait of the cell-of-origin in Ewing sarcoma
Study detected RNF2 expression to be overexpressed in esophageal carcinoma cell lines and was associated with the poor prognosis of esophageal carcinoma patients. Data also reflect its important role in the growth of esophageal carcinoma cells by shRNA silencing of RNF2 expression.
overexpression of RNF2, as examined by immunohistochemical analysis, might serve as a novel prognostic biomarker and potential therapeutic target for urothelial carcinoma of the bladder patients.
Our findings support the notion that epigenetic regulators, such as RNF2, directly and functionally control powerful gene networks that are vital in multiple cancer processes.
O-GlcNAc (show OGT ELISA Kits) modifies and regulates an essential epigenetic tool, RING1B, which may contribute to human embryonic stem cells pluripotency maintenance and differentiation.
The enzymatic activity of BMI1 (show BMI1 ELISA Kits) and RING1B were evaluated and compared.
Data show that RNF2 promotes STAT1 (show STAT1 ELISA Kits)/STAT2 (show STAT2 ELISA Kits) disassociation from DNA.
the ability of RING1B, a core component of PRC1 (show PRC1 ELISA Kits), to ubiquitinate histone H2A is dispensable for early mouse embryonic development and much of the gene repression activity of PRC1 (show PRC1 ELISA Kits)
RNF2 associates with AMBRA1 to act as an E3 ligase to ubiquitinate AMBRA1 via K48 linkage.
The polycomb component Ring1B regulates the timed termination of Fezf2 (show FEZF2 ELISA Kits) expression and thus subcerebral projection neuron production during mouse neocortical development.
Expansion of hepatic stem/progenitor cells requires Ring1B-mediated epigenetic silencing of Cdkn1a (show CDKN1A ELISA Kits) and Cdkn2a, demonstrating that Ring1B simultaneously regulates multiple CDKIs in tissue stem/progenitor cells.
Af9 mediates site-selective physical and functional recruitment of Rnf2 to the alpha-ENaC (show SCNN1A ELISA Kits) promoter to constrain basal alpha-ENaC (show SCNN1A ELISA Kits) transcription in collecting duct cells.
Ring1b mediates Meis2 promoter and midbrain-specific enhancer association.
Aurora B and Ring1B co-occupy active promoters in resting lymphocytes.
Fbxl10 has a key role in regulating Ring1B recruitment to its target genes and H2AK119 ubiquitylation in embryonic stem cells.
identification of gene-dosage-dependent roles in primordial germ cell development for Ring1 and Rnf2, two central components of the Polycomb repressive complex 1 (PRC1 (show PRC1 ELISA Kits))
The polycomb group protein ring1b/rnf2 is specifically required for craniofacial development.
These results reveal that, in the absence of functional Ring1b, fin bud cells fail to execute the pectoral fin developmental program.
Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.
E3 ubiquitin-protein ligase RING2
, HIP2-interacting protein 3
, RING finger protein 1B
, RING finger protein BAP-1
, huntingtin-interacting protein 2-interacting protein 3
, protein DinG
, ring finger protein 1b