Ring Finger Protein 20 Proteins (RNF20)

Mouse (Murine) Ring Finger Protein 20 (RNF20) interaction partners

1. The results demonstrate that Fbxl19 recruitment to CpG islands is required for Rnf20-mediated H2B monoubiquitination.

2. RNF20 and H2Bub1 promotes chronic colonic inflammation and inflammation-associated colorectal cancer in mice and humans, partly by augmenting NF-kappaB (show NFKB1 Proteins) activity and attenuating the antitumoral T cell response.

3. RNF20 plays a critical role in the regulation of hepatic lipid metabolism by modulating the protein stability and transcriptional activity of SREBP1c (show SREBF1 Proteins) during hormonal changes.

4. results suggested that RNF20 may play roles in adipocyte differentiation by stimulating ubiquitin-proteasome-dependent degradation of AP-2alpha (show TFAP2A Proteins).

5. Bre1a-negative cells in the ventricular zone of early embryonic brains remain undifferentiated and are selected as self-renewing neural stem cells

6. model whereby cotranscriptional recruitment of Rnf20 at MLL (show MLL Proteins)-fusion target genes leads to amplification of Dot1l (show DOT1L Proteins)-mediated H3K79 methylation, thereby rendering leukemia cells dependent on Rnf20 to maintain their oncogenic transcriptional program

7. Loss of Bre1 (RNF20) disrupts gene silencing at telomeric chromatin. Most of the genomic instability in the Bre1-deficient cells is attributed to the formation of R-loops.

8. We show that Bre1 (human BRE1A/B (RNF20/40) and mouse Bre1a/b (Rnf20/40)) acts as an important suppressor of chromosomal instability

9. the observed defects in the radiation response of Bre1a/b-deficient cells

Human Ring Finger Protein 20 (RNF20) interaction partners

1. the RNF20/40 complex, a major ubiquitin ligase catalysing histone H2B monoubiquitination, interacts with the motor protein Eg5 (show KIF11 Proteins) during mitosis and participates in spindle assembly.

2. data indicate that RNF20 and PARP1 (show PARP1 Proteins) are synthetic lethal interactors

3. RNF20 depletion stabilizes the ZSCAN4 (show ZSCAN4 Proteins) protein half-life, suggesting that RNF20 negatively regulates ZSCAN4 (show ZSCAN4 Proteins) stability.

4. The effects of RNF20 on mammary tumorigenesis are subtype dependent: In basal-like cancers cells, RNF20 suppresses the NF-kappaB (show NFKB1 Proteins)-dependent expression of cytokines, known to contribute to the growth of this tumor subtype.

5. The authors also show that the RING domains of RNF20 and RNF40 (show RNF40 Proteins) can form a stable heterodimer that is active.

6. Manipulation of key H2Bub1 E3 ubiquitin ligases, RNF20, RNF40 (show RNF40 Proteins) and BRCA1, in ovarian cancer cell line models modulated H2Bub1 levels, indicative of the role of these RING finger (show PCGF1 Proteins) ligases in monoubiquitination of H2Bub1 in vitro

7. RNF20 and H2Bub1 promotes chronic colonic inflammation and inflammation-associated colorectal cancer in mice and humans, partly by augmenting NF-kappaB (show NFKB1 Proteins) activity and attenuating the antitumoral T cell response.

8. It was observed that RE-IIBP induces MEIS1 (show MEIS1 Proteins)-mediated apoptosis, which was dependent on H2BK120 ubiquitination by RNF20.

9. A primary role for FACT in RNF20 recruitment chromatin remodeling for initiation of homologous recombination repair.

10. Together, these results indicate that human adenovirus E1A (show BCKDHA Proteins) uses hBre1 to recruit the hPaf1 (show PAF1 Proteins) complex in order to optimally activate viral early transcription by enhancing transcriptional elongation.