S100 Calcium Binding Protein A10 (S100A10) ELISA Kits

Human S100 Calcium Binding Protein A10 (S100A10) interaction partners

1. the observed reduction in infection is less significant in the absence of S100A10 alone compared to full A2t, supporting an independent role for monomeric AnxA2. More broadly, we show that successful infection by multiple oncogenic HPV types is dependent on A2t.

2. These findings delineate the clinical and functional contribution of S100A10 as a biomarker in pancreatic cancer.

3. High expression of Annexin A2 and S100A10 in stromal tissue from Epithelial Ovarian Cancer patients was associated with reduced overall survival; however, no independent prognostic value was found for any of the markers.

4. The data show that S100A10 expression in lung squamous cell carcinoma is related to invasion of the lymphatic system, cancer stage progress, and a poorer prognosis.

5. study has localised AnxA2/S100A10 complexes to key anatomical locations in the placenta and suggests a role for this complex in amniotic epithelium, trophoblasts and syncytium, in addition to its well-known roles in endothelial cells

6. The overexpression of ANXA2 in U937 cells transfected with full-length ANXA2 cDNA was associated with increased S100A10 subunit, although S100A10 transcripts remained constitutive. PML/RARalpha fusion protein transactivated the ANXA2 promoter to upregulate ANXA2 and accumulate S100A10.

7. these studies define a new paradigm for plasminogen activation by the plasminogen receptor, S100A10

8. These findings provides evidence that gene-gene interactions between p11, tPA and BDNF are all associated with post stroke depression.

9. Given that inflammation plays a role in both Parkinson's disease (PD)and depression, it is intriguing that peripheral p11 levels are altered in immune cells in both conditions. Our data provide insight into the pathological alterations occurring centrally and peripherally in PD. Moreover, if replicated in other cohorts, p11 could be an easily accessible biomarker

10. The S100A10 and S100B genes, which are located on different chromosomes, encode specialized calcium-binding proteins. These data support a role for calcium homeostasis in individuals with Cannabis Dependence and high risk sex behaviours.

11. These findings identify S100A10 as a player in endometrial receptivity acquisition.

12. Findings indicate that Munc13-4 supports acute WPB exocytosis by tethering WPBs to the plasma membrane via AnxA2-S100A10.

13. Here, the authors demonstrate that S100A10 is required for ULK1 localization to autophagosome formation sites. Silencing of S100A10 reduces IFN-gamma-induced autophagosome formation.

14. p11 might be a potential regulator on 5-HTR1b and 5-HTR4 as well as a predictor of or a therapeutic target for IFN-alpha-induced depression.

15. annexin A2 and S100A10 expressions are powerful predictors of serous ovarian cancer outcome.

16. These data show that disruption of ANX2/p11 interaction results in reduced ALL cell adhesion to osteoblasts, increased ALL cell sensitization to chemotherapy, and suppression of ALL cell homing and engraftment.

17. Annexin A2 complexes with S100 proteins: structure, function and pharmacological manipulation

18. Overexpression of miR-590-5P reduced the activity of luciferase expressed by a vector bearing the 3' untranslated region of S100A10 mRNA. Ectopic miR-590-5P overexpression mediated by lentiviral infection decreased expression of S100A10.

19. TPH1 gene polymorphisms and S100A10 expression, which correlate with 5-HT signaling were associated with ramosetron effectiveness in IBS-D, and may possibly lead to prospective identification of the resistance to treatment.

20. Authors show here that AnxA2, p11 and AHNAK are required for type 3 secretion system-mediated Salmonella invasion of cultured epithelial cells.

Mouse (Murine) S100 Calcium Binding Protein A10 (S100A10) interaction partners

1. p11KO male mice showed lower conditioned place preference than WT. In females there were no CPP differences between p11KO and WT.

2. p11 might be a potential regulator on 5-HTR1b and 5-HTR4 as well as a predictor of or a therapeutic target for IFN-alpha-induced depression.

3. data indicate that focal inhibition of p11 action in the dorsal striatum could be a promising PD therapeutic target to improve motor function while reducing l-dopa-induced dyskinesias

4. p11 homeostasis in the NAc, particularly in dopamine receptor-1 expressing medium spiny neurons, may underlie pathophysiological mechanisms of cocaine rewarding action.

5. The level of hippocampal p11 determines the directionality of 5-HT(1B)R action on emotional memory processing and modulates hippocampal functionality.

6. p11 and AnxA2 cooperate to create a unique binding pocket, but the optimal binding condition is not achieved without conformational changes associated with target binding. Upon interaction with the SMARCA3 peptide, both Asp60 in p11 and Ser12 in AnxA2 flip inward toward the peptide-binding groove, forming additional intermolecular hydrogen bonds.

7. Lewis lung carcinoma or T241 fibrosarcoma growth was reduced in S100A10-deficient mice. S100A10 was required specifically for the migratory capability needed for macrophage tumor homing, a new rate-limiting step in tumor progression.

8. An important role for S100A10 in the regulation of fibrinolysis and angiogenesis in vivo, suggesting that S100A10 plays a critical role in endothelial cell function.

9. Data indicate that most p11 expressing cells in cerebral cortex, hippocampus, cerebellum, & caudate-putamen express HTR1B or co-express HTR1B/HTR4, suggesting crucial role for p11 in modulating actions of serotonin via these receptor subtypes.

10. The authors inferred that S100A10 may play an important role in transpenetration of Cryptococcus neoformans across the vascular endothelia.

11. Voluntary physical activity, but not locked wheel exposure, induced a robust increase in hippocampal mature BDNF protein levels, as well as in p11 and tissue plasminogen activator mRNA expression

12. data demonstrate that p11 levels are regulated by BDNF in vitro and in vivo and that the antidepressantlike effect of BDNF in two well-established behavioral models requires p11.

13. Loss of S100A10 led to decrease in macrophage migration across the peritoneal membrane into the peritoneal cavity.

14. p11, already known to traffic members of the voltage-gated sodium and potassium channel families as well as transient receptor potential and chloride channels, also plays a selective role in enhancing ASIC1a functional expression

15. results of the present study indicate that the dynamic modulation of 5-HT1B receptor function by p11 may be involved in molecular adaptations occurring in neuronal networks that are dysfunctional in depression-like states

16. Macrophage migration inhibitory factor is an important androgen-responsive proteins produced by Sertoli cells which might play a role in regulating spermatogenesis.

17. A significant deficit in neuropathic pain behavior in mice with p11 deletion confirms an important role for p11 protein in nociceptor function.

18. We have recently identified increased expression of p11 genes that implicate fibrinolysis in ALD progression.

19. Within the endothelial cell, p11 is required for Src kinase-mediated tyrosine phosphorylation of A2, which signals translocation of both proteins to the cell surface.

20. S100A10 mRNA and protein levels were significantly lower in the cultured ANXA2(-/-) cells than in cultured ANXA2(+/+) cells.