anti-SAM Domain and HD Domain 1 (SAMHD1) Antibodies

SAMHD1 may play a role in regulation of the innate immune response. Additionally we are shipping SAMHD1 Kits (7) and SAMHD1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SAMHD1 25939 Q9Y3Z3
SAMHD1 56045 Q60710
SAMHD1 311580  
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Top anti-SAMHD1 Antibodies at antibodies-online.com

Showing 10 out of 131 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-SAMHD1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Mouse Un-conjugated FACS, ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: SAMHD1 Antibody (3F5) [NBP2-03285] - Staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-SAMHD1 mouse monoclonal antibody. Immunohistochemistry-Paraffin: SAMHD1 Antibody (3F5) [NBP2-03285] - Staining of paraffin-embedded Carcinoma of Human liver tissue using anti-SAMHD1 mouse monoclonal antibody. 0.1 mL Log in to see 7 to 9 Days
$514.63
Details
Human Mouse Un-conjugated FACS, IF, WB Anti-SAMHD1 mouse monoclonal antibody (ABIN2453908) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SAMHD1 (RC206013). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SAMHD1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-SAMHD1. 0.1 mL Log in to see Available
$451.00
Details
Dog Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$522.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IHC, WB Western Blot: SAMHD1 Antibody [NBP1-31432] - Sample (30 ug of whole cell lysate) A: THP-1 7.5% SDS PAGE, antibody diluted at 1:500. Immunocytochemistry/Immunofluorescence: SAMHD1 Antibody [NBP1-31432] - Paraformaldehyde-fixed HeLa, using antibody at 1:500 dilution. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Human Brain, antibody was diluted at 1:100. 100 μL Log in to see 16 Days
$181.73
Details
Human Mouse Un-conjugated FACS, IF, WB Anti-SAMHD1 mouse monoclonal antibody (ABIN2453623) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SAMHD1 (RC206013). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SAMHD1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-SAMHD1. 0.1 mL Log in to see Available
$451.00
Details
Dog Mouse Un-conjugated IF, IHC, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Mouse Un-conjugated IF, WB 100 μL Log in to see 7 to 9 Days
$507.83
Details

Top referenced anti-SAMHD1 Antibodies

  1. Human Monoclonal SAMHD1 Primary Antibody for FACS, IF - ABIN2731368 : Tabler, Lucera, Haqqani, McDonald, Migueles, Connors, Tilton: CD4+ memory stem cells are infected by HIV-1 in a manner regulated in part by SAMHD1 expression. in Journal of virology 2014 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal SAMHD1 Primary Antibody for FACS, IF - ABIN2731369 : Zhang, Bloch, Nguyen, Kim, Landau: SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells. in PLoS ONE 2014 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal SAMHD1 Primary Antibody for ICC, IF - ABIN441436 : Nomaguchi, Doi, Adachi: Virological characterization of HIV-2 vpx gene mutants in various cell systems. in Microbes and infection 2014 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal SAMHD1 Primary Antibody for IF, WB - ABIN525504 : White, Brandariz-Nuez, Valle-Casuso, Amie, Nguyen, Kim, Brojatsch, Diaz-Griffero: Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1. in Virology 2013 (PubMed)

More Antibodies against SAMHD1 Interaction Partners

Human SAM Domain and HD Domain 1 (SAMHD1) interaction partners

  1. study considerably extends the picture of pathways involved in molecular pathogenesis of T-PLL and identifies the tumor suppressor gene SAMHD1 with ~20% of T-PLL affected by destructive lesions likely as major player in T-PLL pathogenesis.

  2. Compared with control cel (show NFKB1 Antibodies)ls, infection of SAMHD1-silenced human mon (show NFKB1 Antibodies)ocytic cells or primary macrophages with Sendai (show NFKB1 Antibodies)virus or HIV-1, or treatment wit (show NFKBIA Antibodies)h inflammatory stimuli, induces significantly higher levels of NF-kappaB act (show IKBKE Antibodies)ivation and IFN-I induction. SAMHD1 (show IRF7 Antibodies) down-regulates innate immune responses to viral infections and inflammatory stimul (show IKBKE Antibodies)i.

  3. SAMHD1 is thus an important player in the replication stress response, which prevents chronic inflammation by limiting the release of single-stranded DNA from stalled replication forks

  4. Low SAMHD1 expression is associated with HIV-1 infection.

  5. Multiple domains of SAMHD1(e.g., N-terminus, nuclear localization signal, linker, HD domain, and C-terminus)are essential for Vpx-induced degradation.[review]

  6. findings indicate a novel role for SAMHD1 in regulating HIV-1 latency, which enhances our understanding of the mechanisms regulating proviral gene expression in CD4 (show CD4 Antibodies)(+) T cells.

  7. results demonstrate that the interaction of CD81 (show CD81 Antibodies) with SAMHD1 controls the metabolic rate of HIV-1 replication by tuning the availability of building blocks for reverse transcription, namely dNTPs

  8. Immune activation during HIV-1 infection influences SAMHD1 expression and degradation.

  9. Studies of the phosphomimetic and tetramerization-defective mutants of SAMHD1 reveal poor correlation between tetramerization propensity and dNTPase activity observed in vitro and the ability of the proteins to deplete cellular dNTPs and to restrict retroviral restriction. These results suggest that enzymatic activity of SAMHD1 may be subject to additional cellular regulatory mechanisms that have not yet been elucidated.

  10. Upregulation of endogenous SAMHD1 expression is attributed to the phosphorylation and nuclear translocation of IRF3 (show IRF3 Antibodies).

Zebrafish SAM Domain and HD Domain 1 (SAMHD1) interaction partners

  1. Data suggest that zebrafish may represent a system for studying the relationship between type I interferon (show IFNA Antibodies) (IFN) signaling and a loss of deoxynucleoside triphosphate triphosphohydrolase SAMHD1 activity.

Mouse (Murine) SAM Domain and HD Domain 1 (SAMHD1) interaction partners

  1. SAMHD1 inhibits NF-kappaB (show NFKB1 Antibodies) activation by interacting with NF-kappaB1 (show NFKB1 Antibodies)/2 and reducing phosphorylation of the NF-kappaB (show NFKB1 Antibodies) inhibitory protein IkappaBalpha (show NFKBIA Antibodies). SAMHD1 also interacts with the inhibitor-kappaB kinase epsilon (IKKepsilon (show IKBKE Antibodies)) and IFN regulatory factor 7 (IRF7 (show IRF7 Antibodies)), leading to the suppression of the IFN-I induction pathway by reducing IKKepsilon (show IKBKE Antibodies)-mediated IRF7 (show IRF7 Antibodies) phosphorylation. SAMHD1 down-regulates innate immune responses to ...

  2. SAMHD1's restriction of dNTP supply enhances AID's mutagenicity and that the evolution of Ig hypermutation included the repurposing of antiviral mechanisms based on dNTP starvation.

  3. SAMHD1 crystal structure delineates the SAMHD1 allosteric activation process that governs SAMHD1 enzymatic activities.

  4. provide genetic evidence that cell-autonomous control of lentivirus infection in myeloid cells by SAMHD1 limits virus-induced production of interferons and the induction of co-stimulatory markers

  5. These data support a model in which SAMHD1 catalytic activity is regulated through tetramer stabilization by the carboxyl-terminal tail, phosphorylation destabilizing the complexes and inactivating the enzyme. ISF2 may serve to reduce the dNTP pool to very low levels as a means of restricting virus replication.

  6. These observations suggest that heterozygous cancer-associated SAMHD1 mutations increase mutation rates in cancer cells.

  7. SAMHD1 in the mouse blocks retroviral infection at the level of reverse transcription and is regulated through cell cycle-dependent phosphorylation.

  8. phosphorylation of mSAMHD1 at T634 by CDK1 (show CDK1 Antibodies)/2 negatively regulates its HIV-1 restriction in differentiated cells, but does not affect its murine leukemia virus restriction in dividing cells.

  9. SAMHD1 restricts HIV-1 replication and regulates interferon (show IFNA Antibodies) production in mouse myeloid cells.

  10. Allosteric regulation by dATP and dTTP works similarly in human and mouse SAMHD1.

SAMHD1 Antigen Profile

Protein Summary

This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome.

Gene names and symbols associated with SAMHD1

  • SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) antibody
  • SAM domain and HD domain 1 (samhd1) antibody
  • SAM domain and HD domain, 1 (Samhd1) antibody
  • SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (Samhd1) antibody
  • CHBL2 antibody
  • DCIP antibody
  • E330031J07Rik antibody
  • HDDC1 antibody
  • Mg11 antibody
  • MOP-5 antibody
  • SBBI88 antibody
  • si:dkeyp-44b8.8 antibody

Protein level used designations for SAMHD1

SAM domain and HD domain-containing protein 1 , dNTPase , dendritic cell-derived IFNG-induced protein , deoxynucleoside triphosphate triphosphohydrolase SAMHD1 , monocyte protein 5 , SAM domain- and HD domain-containing protein 1 , IFN-gamma induced , interferon-gamma-inducible protein Mg11

GENE ID SPECIES
25939 Homo sapiens
524683 Bos taurus
419125 Gallus gallus
485862 Canis lupus familiaris
553453 Danio rerio
56045 Mus musculus
311580 Rattus norvegicus
Selected quality suppliers for anti-SAMHD1 (SAMHD1) Antibodies
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