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The protein encoded by SEC24A belongs to a family of proteins that are homologous to yeast Sec24.
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the association between Kv1.3 (show KCNA3 Antibodies) and the COPII cargo adaptor subunit isoform Sec24a
CstA (show CSTA Antibodies), a secreted Brucella protein specifically interacts with human Sec24A.
Sec24 isoforms expand the repertoire of cargo for signal-mediated ER export, but are in part functionally redundant.
Hepatic LDLR (show LDLR Antibodies) levels are up-regulated in SEC24A-deficient cells as a consequence of specific dependence of PCSK9 (show PCSK9 Antibodies), a negative regulator of LDLR (show LDLR Antibodies), on SEC24A for efficient exit from the ensoplasmic reticulum.
The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
SEC24 related gene family, member A
, protein transport protein Sec24A
, SEC24-related protein A