anti-SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) Antibodies

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. Additionally we are shipping SETD7 Proteins (12) and SETD7 Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SETD7 80854 Q8WTS6
SETD7 73251 Q8VHL1
SETD7 689954  
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Top anti-SETD7 Antibodies at antibodies-online.com

Showing 10 out of 109 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SETD7 Antibody Titration:  5.0ug/ml  Positive Control:  Human Pancreas 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-SET9 Ctr Pab (ABIN387997) is used in Western blot to detect SET9 in mouse brain tissue lysate. Western blot analysis of SET9(arrow) using rabbit polyclonal SET9 Antibody(ABIN387997). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the SET9 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Mouse Un-conjugated ELISA, IF, IHC, IHC (p), WB 50 μg Log in to see 11 to 14 Days
$561.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB Anti-SETD7 / SET7 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN960912 dilution 1:100. Anti-SETD7 / SET7 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100. 50 μL Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated WB 25 μg Log in to see 2 to 3 Days
$185.00
Details
Cow Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  SETD7  Sample Type:  Jurkat Whole Cell lysates  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Bat Rabbit Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$537.17
Details

Top referenced anti-SETD7 Antibodies

  1. Human Monoclonal SETD7 Primary Antibody for ELISA, WB - ABIN532913 : Kwon, Chang, Kwak, Lee, Joachimiak, Kim, Lee, Cho: Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet. in The EMBO journal 2003 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal SETD7 Primary Antibody for ELISA, WB - ABIN543332 : Xiao, Jing, Wilson, Walker, Vasisht, Kelly, Howell, Taylor, Blackburn, Gamblin: Structure and catalytic mechanism of the human histone methyltransferase SET7/9. in Nature 2003 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal SETD7 Primary Antibody for IHC (p), ELISA - ABIN543331 : Wysocka, Myers, Laherty, Eisenman, Herr: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. in Genes & development 2003 (PubMed)
    Show all 3 Pubmed References

  4. Cow (Bovine) Polyclonal SETD7 Primary Antibody for WB - ABIN2783571 : Subramanian, Jia, Kapoor-Vazirani, Powell, Collins, Sharma, Peng, Cheng, Vertino: Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. in Molecular cell 2008 (PubMed)

  5. Human Polyclonal SETD7 Primary Antibody for ChIP, IHC (p) - ABIN252611 : Narayanan, Ruyechan, Kristie: The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)

  6. Human Polyclonal SETD7 Primary Antibody for WB - ABIN6687230 : Yin, Jia, Miron, Long, Xu, Wei, Wu, Zhang, Li: Setd7 and its contribution to Boron-induced bone regeneration in Boron-mesoporous bioactive glass scaffolds. in Acta biomaterialia 2018 (PubMed)

More Antibodies against SETD7 Interaction Partners

Human SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) interaction partners

  1. Setd7 plays an positive role in osteogenic differentiation

  2. these results reveal how SETD7 acts at sequential steps in cardiac lineage commitment.

  3. SET9 is broadly required for the effects of TGFB1 in diseased primary renal fibroblasts; SET9 promotes fibroblast migration into wounds, expression of extracellular matrix proteins, collagen contractility and myofibroblast differentiation. SET9 is recruited to the alpha-smooth muscle actin gene in response to TGFB1, providing a mechanism by which SET9 regulates myofibroblast contractility and differentiation.

  4. data indicate that SETD7 could serve as a potential diagnostic and prognostic biomarker for colorectal cancer.

  5. Setd7 knockdown decreases Nrf2 and Nrf2-target genes expression, and phenethyl isothiocyanate and ursolic acid induce Setd7 expression, which activates the Nrf2/antioxidant response element signaling pathway and protects DNA from oxidative damage.

  6. Setd7 KD impacted a larger set of genes and caused a higher fold change compared to PEITC treatment. This study offers new insights into the mechanisms of action of the epigenetic modifier Setd7 and the effects of PEITC treatment in PCa cells and enhances our understanding of the potential cancer preventive/treatment effects of isothiocyanate compounds such as PEITC in PCa.

  7. High SET7 expression is associated with hepatocellular carcinoma progression.

  8. SET7/9 expression in nonadherent cells isolated from the effluent of peritoneal dialysis (PD) patients. SET7/9 expression was elevated in nonadherent cells isolated from the effluent of PD patients. SET7/9 expression was positively correlated with dialysate/plasma ratio of creatinine in PD patients.

  9. Methylation at K436 and K595 respectively by Set7 increases the stability and DNA binding ability of Gli3, resulting in an enhancement of Shh signaling activation.

  10. the methyltransferase Set9 potentiates TGF-beta signaling by targeting Smad7, an inhibitory downstream effector.

  11. SET9 expression levels were significantly higher in samples from patients with pathological complete remission than in samples from patients with disease recurrence, which indicates that SET9 acts as a tumor suppressor in breast cancer and that its expression may serve as a prognostic marker for malignancy.

  12. SETD7 plays a critical role in HCC, and its immunohistochemistry signature provides potential clinical significance for personalized prediction of HCC prognosis.

  13. These findings underscore the role of KMT7 as an important monomethyltransferase regulating HIV transcription through Tat.

  14. High SET7 expression is associated with breast cancer.

  15. SET7 was required for GATA1-induced breast tumor angiogenesis and growth in nude mice. GATA1 and SET7 are independent poor prognostic factors in breast cancer.

  16. SET7/SET9-mediated YY1 methylation was shown to be involved in YY1-regulated gene transcription and cell proliferation.

  17. These results demonstrate that S...O chalcogen bonds contribute to AdoMet recognition and can enable methyltransferases to distinguish between substrate and product.

  18. Reduced expression of SET7 is associated with gastric cancer progression.

  19. study identified a novel locus associated with serum lycopene concentrations and results raise a number of possibilities regarding the nature of the relationship between SETD7 and lycopene, both independently associated with prostate cancer.

  20. Lysine methylation by SETD7 is important for the fine-tuning of reactive oxygen species signaling through its regulation on pro-inflammatory responses.

Mouse (Murine) SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) interaction partners

  1. Murine peritoneal fibrosis was induced by intraperitoneal injection of methylglyoxal (MGO). SET7/9 expression was elevated in MGO-injected mice.

  2. spinal SET7/9 may contribute to the maintenance of CIBP

  3. the methyltransferase Set9 potentiates TGF-beta signaling by targeting Smad7, an inhibitory downstream effector.

  4. SETD7 plays an important role in intestinal epithelial cell (IEC) biology during infection.

  5. We observe Set7-mediated modification of serum response factor (SRF) and mono-methylation of histone H4 lysine 4 (H3K4me1) regulate gene expression. We conclude the broad substrate specificity of Set7 serves to control key transcriptional networks in embryonic stem cells.

  6. SETD7 is required for Wnt-driven intestinal tumorigenesis and regeneration. SETD7-dependent methylation of YAP facilitates Wnt-induced nuclear accumulation of beta-catenin.

  7. SET7/9 regulates Nos2 expression through methylation of H3K4 in beta cells.

  8. Data indicate that the ability of transcription factor Pdx1 to regulate genes in beta cells is partially dependent upon its methylation by methyltransferase Set7/9.

  9. study found that Set7 is a modifier of the Hippo pathway. Mice that lack Set7 have a larger progenitor compartment in the intestine, coinciding with increased expression of Yes-associated protein target genes.

  10. The response to hyperglycemia in vascular endothelial cells involves Set7 mediated changes in chromatin remodeling and gene expression.

  11. Set7/9-mediated methylation of p53 does not represent a major regulatory event and does not appreciably control p53 activity in vivo.

  12. Set7/9 is dispensable for p53 function in the mouse.

  13. Define a biological function for Set7 in muscle differentiation and provide a molecular mechanism by which Set7 modulates myogenic transcription factors during muscle differentiation.

  14. Pdx1-dependent Set7/9 expression may be crucial to enhancing chromatin accessibility and transcription of beta-cell genes.

  15. Methylation of p53 by Set7 mediates p53 acetylation and activity in vivo.

  16. a novel role for SET7/9 in inflammation and diabetes.

  17. Data conclude that Set7/9 is required for normal beta-cell function, likely through the maintenance of euchromatin structure at genes necessary for glucose-stimulated insulin secretion.

  18. ASCOM-MLL3 and ASCOM-MLL4 likely function as crucial but redundant H3K4MT complexes for PPARgamma-dependent adipogenesis

SETD7 Antigen Profile

Protein Summary

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the -K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Gene names and symbols associated with SETD7

  • SET domain containing lysine methyltransferase 7 (SETD7) antibody
  • SET domain containing (lysine methyltransferase) 7 (setd7) antibody
  • SET domain containing (lysine methyltransferase) 7 (Setd7) antibody
  • 1600028F23Rik antibody
  • H3K4MT antibody
  • KMT7 antibody
  • mKIAA1717 antibody
  • Set7 antibody
  • Set7/9 antibody
  • SET9 antibody
  • zgc:92330 antibody
  • zgc:101860 antibody

Protein level used designations for SETD7

H3-K4-HMTase SETD7 , SET domain-containing protein 7 , histone H3-K4 methyltransferase SETD7 , histone H3-lysine 4-specific methyltransferase , histone-lysine N-methyltransferase SETD7 , lysine N-methyltransferase 7 , H3-K4 methyltransferase

GENE ID SPECIES
80854 Homo sapiens
436729 Danio rerio
73251 Mus musculus
689954 Rattus norvegicus
476079 Canis lupus familiaris
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