anti-SET and MYND Domain Containing 2a (SMYD2A) Antibodies

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Additionally we are shipping SMYD2A Proteins (16) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SMYD2A 56950 Q9NRG4
SMYD2A 226830 Q8R5A0
SMYD2A 289372 Q7M6Z3
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Top anti-SMYD2A Antibodies at antibodies-online.com

Showing 10 out of 78 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated ChIP, WB WB Suggested Anti-SMYD2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  SH-SYSY cell lysate SMYD2 is supported by BioGPS gene expression data to be expressed in SHSY5Y Quiescent human colon carcinoma HCT116 cultures were treated with 10% FBS for three time points (0, 15, 30min) or (0, 30, 60min) were used in Matrix-ChIP and real-time PCR assays at EGR1 gene (Exon1) and 15kb upstream site. 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SMYD2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  ACHN cell lysate SMYD2 is supported by BioGPS gene expression data to be expressed in ACHN WB Suggested Anti-SMYD2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: ACHN cell lysate  SMYD2 is supported by BioGPS gene expression data to be expressed in ACHN 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of SYMD2 (arrow) using rabbit polyclonal SYMD2 Antibody (N-term) (ABIN387897).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the SYMD2 gene (Lane 2) (Origene Technologies). SMYD2 Antibody (N-term) (ABIN387897) western blot analysis in NCI-H292 cell line lysates (35 µg/lane).This demonstrates the SMYD2 antibody detected the SMYD2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated WB   200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 16 Days
$181.73
Details
Cow Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of Phospho-SMYD2(Ser283) in lysates of NIH 3T3, using Phospho-SMYD2(Ser283) Antibody(ABIN6269600). 100 μL Log in to see 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: SMYD2 Antibody [NBP1-83186] - Staining of human cell line U-2 OS shows positivity in cytoplasm & mitochondria. Immunohistochemistry: SMYD2 Antibody [NBP1-83186] - Staining of human duodenum shows strong cytoplasmic positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis SMYD2 using LOVO whole cell lysates 100 μL Log in to see 11 to 12 Days
$390.77
Details

Top referenced anti-SMYD2A Antibodies

  1. Human Polyclonal SMYD2A Primary Antibody for ELISA, WB - ABIN4369823 : Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007 (PubMed)
    Show all 2 Pubmed References

  2. Cow (Bovine) Polyclonal SMYD2A Primary Antibody for ChIP, WB - ABIN2784266 : Shibamoto, Ogino, Suzuki, Takemoto, Araki, Isobe, Tsuchida, Nakamura, Kenjo, Suzuki, Hosono, Tokumaru, Ishihara, Kato, Ii, Hayabuchi: Primary central nervous system lymphoma in Japan: changes in clinical features, treatment, and prognosis during 1985-2004. in Neuro-oncology 2008 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal SMYD2A Primary Antibody for IF, WB - ABIN6148167 : Gao, Wang, Wang, Hu, Chen, Li, Feng, Wong, Du: The lysine methyltransferase SMYD2 methylates the kinase domain of type II receptor BMPR2 and stimulates bone morphogenetic protein signaling. in The Journal of biological chemistry 2017 (PubMed)

More Antibodies against SMYD2A Interaction Partners

Human SET and MYND Domain Containing 2a (SMYD2A) interaction partners

  1. Study shows a significant association between the methylation status of CpGs in the SMYD2 promoter and SMYD2 gene decreased expression in abdominal aortic aneurysm.

  2. We found that SMYD2 expression was significantly related to tumor size (P<0.001), lymph node metastasis (P<0.005), and TNM stage (P<0.005). However, no correlations were found between SMYD2 expression and patient age, sex, thyroid capsular invasion (TCI), or extrathyroidal extension (all P>0.05).

  3. We show that tool compounds as well as CRISPR/Cas9 fail to reproduce many of the cell proliferation findings associated with SMYD2 and SMYD3 inhibition previously obtained with RNAi based approaches and with early stage chemical probes.

  4. Lysine methylation represses p53 activity in teratocarcinoma cancer cells via up-regulation of SMYD2 and PR-Set7 and perpetuation of cancer cells proliferation.

  5. SMYD2-H4K20me1-L3MBTL1 axis contributes to HIV-1 latency and can be targeted with small-molecule SMYD2 inhibitors.

  6. identifie novel cellular substrates of the lysine methyltransferase SMYD2. Of the 14 novel putative SMYD2 substrates identified, six were confirmed in cells by immunoprecipitation: MAPT, CCAR2, EEF2, NCOA3, STUB1, and UTP14A. Treatment with the selective SMYD2 inhibitor BAY-598 abrogated the methylation signal, indicating that methylation of these novel substrates was dependent on the catalytic activity of SMYD2

  7. The SMYD2 may promote BMP signaling by directly methylating BMPR2, which, in turn, stimulates BMPR2 kinase activity and activation of the BMP pathway.

  8. Knockdown of SMYD2 as well as treatment with a SMYD2 inhibitor in two NSCLC cell lines with an EML4-ALK gene significantly attenuated the phosphorylation levels of the EML4-ALK protein.

  9. SMYD2 knockdown confers relative resistance to human AML cells against multiple classes of DNA damaging agents.

  10. Substrate crevices of Smyd2 and Smyd3 show distinct features in terms of spatial, hydration, and electrostatic properties that emphasize their characteristic modes of substrates interaction and entry pathways for inhibitor binding.

  11. High expression of SMYD2 is associated with chronic lymphocytic leukemia.

  12. Study reveals a collection of 10 enriched sequence motifs in Kme1 sites that were identified upon SMYD2 overexpression which were also downregulated in response to SMYD2 knockdown. These findings suggest that these motifs reflect the substrate specificity of SMYD2 in esophageal squamous cell carcinoma cell line.

  13. Results show that high expression levels of SMYD2, SETD3, and NO66 in renal cell tumors. Their low expression levels were significantly associated with shorter disease-specific and disease-free survival.

  14. Suggest that SMYD2 plays a role in tumor progression and might be a useful prognosticator in HPV-unrelated, nonmultiple head and neck squamous cell carcinomas.

  15. SMYD2-mediated methylation negatively regulates PTEN tumor suppressor activity and results in activation of the phosphatidylinositol 3-kinase-AKT pathway.

  16. Comprehensive motif-based searches and mutational analysis further established four additional substrates of SMYD2.

  17. in addition to esophageal squamous cell carcinoma, SMYD2 is also amplified and/or overexpressed in breast and liver primary tumors

  18. a novel mechanism of PARP1 in human cancer through its methylation by SMYD2

  19. SMYD2 has a crucial role in tumor cell proliferation by its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in gastric cancer.

  20. Data indicate that irect estrogen receptor alpha (ERalpha) methylation by histone methyltransferase SMYD2 regulates estrogen signaling.

Mouse (Murine) SET and MYND Domain Containing 2a (SMYD2A) interaction partners

  1. Our data indicate that Smyd2 has a critical role downstream of Myc in acute myeloid leukemia

  2. two positive feedback loops that integrate epigenetic regulation and renal inflammation in cyst development: SMYD2/IL-6/STAT3/SMYD2 and SMYD2/TNF-alpha/NF-kappaB/SMYD2.

  3. a pivotal role for SMYD2 in promoting pancreatic cancer.

  4. Data show that histone methyltransferase Smyd2 inhibits macrophage interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) production. production.

  5. Smyd2 is a lysine methyltransferase which has, next to its nuclear activity, specific regulatory functions in the cytoplasm of heart and skeletal muscle cells.

  6. Smyd2, similar to Smyd3, interacts with RNA Polymerase II as well as to the RNA helicase, HELZ

  7. Sin3A-mediated deacetylation within the coding regions of active genes is directly linked to the histone methyltransferase activity of Smyd2 [Symd2]

  8. results show that Smyd2 negatively regulates p53-responsive genes in a p53-dependent manner

Zebrafish SET and MYND Domain Containing 2a (SMYD2A) interaction partners

  1. Findings suggest that SMYD2 (SET and MYND domain containing protein 2), a histone lysine methyltransferase, plays a critical role at early stages of development.

SMYD2A Antigen Profile

Protein Summary

SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006

Gene names and symbols associated with SMYD2A

  • SET and MYND domain containing 2 (SMYD2) antibody
  • SET and MYND domain containing 2 (Smyd2) antibody
  • SET and MYND domain containing 2 S homeolog (smyd2.S) antibody
  • SET and MYND domain containing 2a (smyd2a) antibody
  • 1110020E07Rik antibody
  • 4930402C15 antibody
  • HSKM-B antibody
  • im:7146196 antibody
  • KMT3C antibody
  • smyd2 antibody
  • smyd2-a antibody
  • wu:fc02f02 antibody
  • zgc:110553 antibody
  • Zmynd14 antibody

Protein level used designations for SMYD2A

N-lysine methyltransferase SMYD2 , SET and MYND domain-containing protein 2 , histone methyltransferase SMYD2 , lysine N-methyltransferase 3C , zinc finger, MYND domain containing 14 , HSKM-B protein , Histone methyltransferase SMYD2-A , N-lysine methyltransferase SMYD2-A , SET and MYND domain-containing protein 2A , SET and MYND domain containing 2 , histone methyltransferase SMYD2-A , Histone methyltransferase SMYD2 , SET and MYND domain-containing 2

GENE ID SPECIES
56950 Homo sapiens
226830 Mus musculus
289372 Rattus norvegicus
379943 Xenopus laevis
421361 Gallus gallus
541423 Danio rerio
615229 Bos taurus
100294706 Sus scrofa
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