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SUGT1 is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Additionally we are shipping SGT1, Suppressor of G2 Allele of SKP1 (S. Cerevisiae) Proteins (11) and SGT1, Suppressor of G2 Allele of SKP1 (S. Cerevisiae) Kits (4) and many more products for this protein.
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Human Monoclonal SUGT1 Primary Antibody for IF, WB - ABIN968739
Kitagawa, Skowyra, Elledge, Harper, Hieter: SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. in Molecular cell 1999
Show all 2 Pubmed References
Data suggest that PHLPP1 (show PHLPP1 Antibodies) plays an important role in assembly of kinetochores by counteracting RNF41 (show RNF41 Antibodies)-mediated SGT1 degradation. (PHLPP1 (show PHLPP1 Antibodies) = PH domain and leucine rich repeat protein phosphatase 1 (show PHLPP1 Antibodies); RNF41 (show RNF41 Antibodies) = ring finger protein 41 (show RNF41 Antibodies); SGT1 = suppressor of G2 allele of SKP1)
Fusion of human SGT1 (hSGT1 (show ECD Antibodies)) to NOD1 (show NOD1 Antibodies) LRR significantly enhanced the solubility, and the fusion protein was stabilized by coexpression of mouse Hsp90alpha (show HSP90AA2 Antibodies).
Data (including data from studies using purified proteins/hepatocyte lysates) suggest eEF1A1 (show EEF1A1 Antibodies)/Sgt1a interact as multimer; D2/D3 domains of eEF1A1 (show EEF1A1 Antibodies) and TPR domain of Sgt1 are involved in multimer formation; Sgt1 competes with viral RNA to bind to eEF1A (show EEF1A1 Antibodies).
Data suggest that SspH2 (ubiquitin ligase effector from Salmonella typhimurium) ubiquitination activity and protein stability is enhanced by SGT1.
our data revealed a previously uncovered role of SGT1 in gastric cancer development, and suggested that SGT1 could be a promising anti-cancer target to against gastric cancer
Chp-1 (show CHP Antibodies) and melusin (show ITGB1BP2 Antibodies) can interact with cochaperones PP5 (show PPP5C Antibodies) and Sgt1 and with each other in an ATP-dependent manner
Plk1 (show PLK1 Antibodies) is required for the kinetochore localization of Sgt1 and phosphorylates serine 331 of Sgt1 at the kinetochores.
Sgt1 translocates to the nucleus due to heat shock. S100A6 (show S100A6 Antibodies) is necessary for nuclear translocation of the Sgt1 protein.
S100A6 (show S100A6 Antibodies)-Ca(2 (show CA2 Antibodies)+)-mediated Sgt1 dephosphorylation promotes its nuclear translocation, most likely due to disruption of the Sgt1-Hsp90 (show HSP90 Antibodies) complex
SUGT1 amplification might give rise to promoting transcription of the gene directly subsequent to the progression of colorectal cancer cases with worsening prognosis
Chp-1 (show CHORDC1 Antibodies) and melusin (show ITGB1BP2 Antibodies) can interact with cochaperones PP5 (show PPP5C Antibodies) and Sgt1 and with each other in an ATP-dependent manner
This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions. Two transcript variants encoding different isoforms have been found for this gene.
suppressor of G2 allele of SKP1 homolog
, suppressor of G2 allele of SKP1
, SGT1B protein
, putative 40-6-3 protein
, suppressor of G2 allele of SKP1, S. cerevisiae, homolog of