anti-SH2B Adaptor Protein 1 (SH2B1) Antibodies

SH2B1 encodes a member of the SH2-domain containing mediators family. Additionally we are shipping SH2B Adaptor Protein 1 Proteins (6) and SH2B Adaptor Protein 1 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SH2B1 25970 Q9NRF2
SH2B1 20399 Q91ZM2
SH2B1 89817 Q62985
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Top anti-SH2B Adaptor Protein 1 Antibodies at antibodies-online.com

Showing 10 out of 71 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 6 to 7 Days
$296.69
Details
Human Mouse Un-conjugated ELISA, IF, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$461.00
Details
Human Rabbit Un-conjugated IF, IHC, WB 100 μL Log in to see 16 Days
$334.77
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-SH2B1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other form ... 50 μg Log in to see 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis using SH2B1 Antibody (C-term) Cat.-No AP53895PU-N in 293 cell line lysates (35ug/lane).This demonstrates the SH2B1 antibody detected the SH2B1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF/ICC, IHC Immunohistochemistry of paraffin-embedded rat kidney using SH2B1 Antibody (ABIN5973245) at dilution of 1/100 (40x lens). Immunohistochemistry of paraffin-embedded human liver cancer using SH2B1 Antibody (ABIN5973245) at dilution of 1/100 (40x lens). 100 μL Log in to see 11 to 16 Days
$426.40
Details
Human Rabbit Un-conjugated WB SH2B1 Antibody (C-term)  western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SH2B1 antibody detected the SH2B1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of Mouse brain lysate, using SH2B1 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277646 at 1/100 staining Mouse muscle tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Mouse Un-conjugated IF, ELISA, WB Western Blot analysis of SH2B1 expression in transfected 293T cell line by SH2B1 monoclonal antibody (M01), clone 2B9.<br><br>Lane 1: SH2B1 transfected lysate(52.917 KDa).<br>Lane 2: Non-transfected lysate.<br> Detection limit for recombinant GST tagged SH2B is approximately 0.03ng/ml as a capture antibody. 100 μg Log in to see 11 to 12 Days
$440.00
Details

Top referenced anti-SH2B Adaptor Protein 1 Antibodies

  1. Cow (Bovine) Polyclonal SH2B1 Primary Antibody for ELISA - ABIN268802 : OBrien, OShea, Carter-Su: SH2-B family members differentially regulate JAK family tyrosine kinases. in The Journal of biological chemistry 2002 (PubMed)

More Antibodies against SH2B Adaptor Protein 1 Interaction Partners

Human SH2B Adaptor Protein 1 (SH2B1) interaction partners

  1. This study is the first to show that neuronal SH2B1, a key protein in insulin (show INS Antibodies) signaling, may have a role in the accumulation of Abeta42 in an animal model of Alzheimer's Disease.

  2. Chromosome microarray analysis was performed on both twins and their parents. An identical 244 kb microdeletion on 16p11.2 including 9 Refseq genes, including SH2B1, was identified in the twins.

  3. SH2B1 fine-tunes global-local chromatin states.

  4. SH2B1 and RABEP1 (show RABEP1 Antibodies) genetic variants are associated with worsening of LDL and glucose parameters in patients treated with psychotropic drugs

  5. SH2B1 polymorphisms are associated with HbA1c, largely independent of BMI, in European American young adults.

  6. Results identified SH2B as a functional target of miR (show MLXIP Antibodies)-361 which down-regulation suppresses lung cancer progression and metastasis through regulation of SH2B1.

  7. that SH2B1 is a key positive mediator of pathological cardiac hypertrophy

  8. Mutation analysis has demonstrated that variation in the SH2B1 gene is frequent in both lean and obese groups, with distinctive variations being present on either side of the weight spectrum.

  9. The rs7359397 (SH2B1) was associated with the body weight, body mass index, and truncal fat mass reduction.

  10. 4 novel variants in SH2B1 were identified in individuals with obesity and insulin (show INS Antibodies) resistance.

Mouse (Murine) SH2B Adaptor Protein 1 (SH2B1) interaction partners

  1. data identify SH2B1 as a major regulator of IRS2 (show IRS2 Antibodies) stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2 (show IRS2 Antibodies), and identify 4E-BP2 (show EIF4EBP2 Antibodies) as a major regulator of proliferation and survival of beta-cells.

  2. that SH2B1 is a key positive mediator of pathological cardiac hypertrophy

  3. SH2B1 in pancreatic beta-cells promotes insulin (show INS Antibodies) synthesis and secretion at least in part by enhancing activation of JAK2 (show JAK2 Antibodies) and/or Pdx1 (show PDX1 Antibodies) pathways in response to hormonal and nutritional signals.

  4. hepatic SH2B1 is not required for the maintenance of normal insulin (show INS Antibodies) sensitivity and glucose metabolism; however, it regulates liver triacylglycerol synthesis, lipolysis, and VLDL secretion.

  5. These data indicate that SH2B1 in beta-cells is an important prosurvival and proproliferative protein and promotes compensatory beta-cell expansion in the insulin (show INS Antibodies)-resistant state and in response to beta-cell stress.

  6. SH2B1 is responsive to erythropoietin (show EPO Antibodies) stimulation and becomes phosphorylated

  7. Leptin (show LEP Antibodies)-stimulated activation of hypothalamic JAK2 (show JAK2 Antibodies) and phosphorylation of hyphothalamic IRS2 (show IRS2 Antibodies) were significantly impaired in SH2B1(-/-) mice.

  8. Mutations in the SH2 (show MYO15 Antibodies) domain of SH2B1 may increase the susceptibility to obesity and type 2 diabetes in a dominant-negative manner.

  9. Genetic deletion of SH2B1 also resulted in growth retardation, obesity, and type 2 diabetes in mice; surprisingly, life span and oxidative resistance were reduced in SH2B1 null mice.

  10. These results suggest that SH2 (show MYO15 Antibodies)-Bbeta regulation of Akt (show AKT1 Antibodies) partly participates in the NGF (show NGFB Antibodies)-mediated development of allergic airway challenge.

SH2B Adaptor Protein 1 (SH2B1) Antigen Profile

Protein Summary

This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with SH2B1

  • SH2B adaptor protein 1 (SH2B1) antibody
  • SH2B adaptor protein 1 (sh2b1) antibody
  • SH2B adaptor protein 1 (Sh2b1) antibody
  • AI425885 antibody
  • C530001K22Rik antibody
  • Irip antibody
  • mKIAA1299 antibody
  • PSM antibody
  • Sh2-b antibody
  • SH2-Bb antibody
  • Sh2b antibody
  • SH2B3 antibody
  • Sh2bpsm1 antibody
  • zgc:158474 antibody

Protein level used designations for SH2B1

SH2B adapter protein 1 , SH2B adaptor protein 1 , SH2B adapter protein 1-like , SH2 domain-containing protein 1B , SH2 domain-containing putative adapter SH2-B , SH2-B signaling protein , pro-rich, PH and SH2 domain-containing signaling mediator , PSM , SH2-B PH domain containing signaling mediator 1 , SH2-B PH domain-containing signaling mediator 1 , fceRI gamma-chain-interacting protein SH2-B

GENE ID SPECIES
506066 Bos taurus
558152 Danio rerio
708160 Macaca mulatta
100064371 Equus caballus
100385268 Callithrix jacchus
100470297 Ailuropoda melanoleuca
100587926 Nomascus leucogenys
25970 Homo sapiens
20399 Mus musculus
89817 Rattus norvegicus
612792 Canis lupus familiaris
100516788 Sus scrofa
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