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Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Additionally we are shipping SHC (Src Homology 2 Domain Containing) Family, Member 4 Proteins (4) and many more products for this protein.
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Mouse (Murine) Polyclonal SHC4 Primary Antibody for WB - ABIN1881806
Jones, Hardy, Friese, Jorgensen, Smith, Woody, Burden, Pawson: Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase. in Molecular and cellular biology 2007
Show all 2 Pubmed References
Human Monoclonal SHC4 Primary Antibody for ELISA, WB - ABIN567062
Azzalin, Moretti, Arbustini, Magrassi: Cell density modulates SHC3 expression and survival of human glioblastoma cells through Fak activation. in Journal of neuro-oncology 2014
ShcD appears to possess several molecular permutations that actively govern the EGFR (show EGFR Antibodies), which may have implications in development and disease.
ShcD binds to active Ret (show RET Antibodies), TrkA (show NTRK1 Antibodies), and TrkB (show NTRK2 Antibodies) neurotrophic factor (show NTF3 Antibodies) receptors predominantly via its phosphotyrosine-binding (PTB (show PTBP1 Antibodies)) domain.
The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor (show EGFR Antibodies).
ShcD can exist within the nucleus, and its CH2 (show Acyp1 Antibodies) domain has a critical role in nuclear export of ShcD.
ShcD binds to TrkC in a kinase-activity-dependent manner through its PTB and SH2 domains.
ShcD interacts with TrkB (show NTRK2 Antibodies) in a kinase-activity-dependent manner.
A new member of the Shc (show SHC1 Antibodies) family of docking proteins is characterised, which may mediate a specific aspect of signaling downstream of the MuSK (show MUSK Antibodies) receptor.
Shc4 is an important modulator in the switch of key pathway(s) involved in determining epiblast stem cell identity.
The unique tissue distribution patterns of Shc (show SHC1 Antibodies) proteins likely contribute to their complex tissue-specific signaling functions during embryogenesis.
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
SHC-transforming protein 4
, SH2 domain protein C4
, SHC-transforming protein D
, rai-like protein
, src homology 2 domain-containing-transforming protein C4
, novel phosphotyrosine interaction domain (PTB/PID) and SH2 domains containing protein
, rai-like protein RaLP