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The protein encoded by SIX6 is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product.
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SIX3 and SIX6 play distinct but compensatory roles in regulating transcription of gonadotrope-specific genes as gonadotrope cells differentiate.
Six6-null mice display abnormal patterns of circadian behavior.
SoxB1 transcription factors are direct activators of Six6 expression in the ventral forebrain
Six6 plays an important role in the regulation of GnRH expression and hypothalamic control of fertility.
in association with Dach (show DACH1 ELISA Kits) corepressors, regulates proliferation of retinal and pituitary precursor cells by directly repressing cyclin-dependent kinase (show CDK1 ELISA Kits) inhibitors, including the p27Kip1 (show CDKN1B ELISA Kits) promoter
Six 3 and Six 6 are differentially required during forebrain development; gene expression in brain
Results show that Lhx2 (show LHX2 ELISA Kits) and Pax6 (show PAX6 ELISA Kits) transcription factors operate in a concerted manner during retinal development to promote transcriptional activation of the Six6 homeobox (show PRRX1 ELISA Kits)-gene in primitive and mature retinal progenitors.
Data show that both six6.L and six6.S expression was restricted to the retina and optic stalk of tailbud embryos.
2 evolutionary conserved regions 5' and a third 3' to the six6 coding region were identified. The conserved 3' region was necessary and sufficient for eye field and optic vesicle expression. Both conserved enhancer regions located 5' of the coding sequence were required for normal optic cup and mature retinal expression.
The results suggest that SIX6 influences different stages of RGC differentiation and their survival; therefore, alteration in SIX6 function due to the risk allele may lead to cellular and molecular abnormalities.
We replicated the association of SNP rs10483727 in the SIX1/SIX6 locus with POAG in a Saudi cohort, suggesting its role in increasing susceptibility to Primary Open Angle Glaucoma .
Among 8 SNPs in 3 loci that showed at least nominal association (P < 5.00E-02) in the primary cohort, a representative SNP for each loci (rs2157719 for CDKN2B-AS1, rs33912345 for SIX6, and rs9913911 for GAS7) were selected
elevated expressions of SIX2, SIX4, and SIX6 predicted poor overall survival (OS) in NSCLC and poor relapse-free survival (RFS) in lung adenocarcinoma
study replicated the association of POAG with two SNPs at the SIX1-SIX6 locus and demonstrated that SNPs, rs10483727 and rs33912345, are significantly associated with POAG, especially with NTG in patients aged above 40 years
Six1 regulates p53 (show TP53 ELISA Kits) via a dual mechanism involving upregulation of microRNA-27a and downregulation of RPL26 (show RPL26 ELISA Kits).
Single nucleotide polymorphism in SIX6 gene is associated with primary open angle glaucoma.
SIX6 and/or intraocular pressure promotes primary open-angle glaucoma by directly increasing p16INK4a expression.
we report a homozygous missense mutation of SIX6 associated with a unique eye phenotype characterized by optic disc anomalies, macular atrophy, and coloboma of the iris and chorioretina.
Nonglaucomatous individuals with the SIX6 missense variant have reduced RNFL thickness in regions known to be particularly affected in those with glaucoma.
a new helix in the C-terminal domain of the mutated bovine SIX6 protein was revealed, which possibly affects pituitary development and hormone secretion
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2).
homeobox protein SIX6
, optic homeobox 2
, sine oculis homeobox homolog 6
, sine oculis-related homeobox 6 homolog
, sine oculis-related homeobox 6a
, homeobox protein Optx2
, homeodomain protein OPTX2