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Acts as a TGF-beta antagonist in the nervous system (By similarity). Additionally we are shipping and many more products for this protein.
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Human Polyclonal SKOR2 Primary Antibody for IHC, IHC (p) - ABIN4353965
Haldipur, Dang, Aldinger, Janson, Guimiot, Adle-Biasette, Dobyns, Siebert, Russo, Millen: Phenotypic outcomes in Mouse and Human Foxc1 dependent Dandy-Walker cerebellar malformation suggest shared mechanisms. in eLife 2017
Experiments performed using mice, but the observations maybe relevant to other organisms as well.
Results verify IRX1 (show IRX3 Antibodies), EBF3 (show MAPRE3 Antibodies), SLC5A8 (show SLC5A8 Antibodies), SEPT9 (show SEPT9 Antibodies), and FUSSEL18 as valid methylation markers in two separate sets of HNSCC specimens; also preliminarily show a trend between HPV16 positivity and target gene hypermethylation of IRX1 (show IRX3 Antibodies), EBF3 (show MAPRE3 Antibodies), SLC5A8 (show SLC5A8 Antibodies), and SEPT9 (show SEPT9 Antibodies).
The first SNP rs29972765 is located in a gene desert on chromosome 18, about 72 kb upstream of Skor2 . The second SNP rs30415957 resides in the intron of Plce1 (show PLCE1 Antibodies).The remaining two SNPs (rs30768258 and rs31216810) are close to each other on chromosome 19, in the vicinity of Sorbs1 (show SORBS1 Antibodies). Knockdown of Sorbs1 (show SORBS1 Antibodies) by siRNA attenuates the induction of differentiation marker gene Prl8a2
Corl2/Skor2 has a role in regulating cerebellar Purkinje cell differentiation in a pathway involving RORalpha
essential function for Skor2 as a novel transcriptional regulator in Purkinje cells that acts upstream of Shh (show SHH Antibodies) during cerebellum development
Results strongly suggest that Corl2 is a specific marker for Purkinje cells in the cerebellum from their emergence until the adult stage.
Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity.
SKI family transcriptional corepressor 2
, LBX1 corepressor 1-like protein
, functional Smad-suppressing element on chromosome 18
, functional smad suppressing element 18
, ladybird homeobox corepressor 1-like protein
, functional Smad suppressor element on chromosome 18
, fussel-18 homolog
, transcriptional corepressor Corl2