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This intronless gene encodes a member of the SLITRK protein family. Additionally we are shipping SLIT and NTRK-Like Family, Member 1 Antibodies (71) and SLIT and NTRK-Like Family, Member 1 Kits (2) and many more products for this protein.
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Data provide partial support for the implication of SLITRK1 in the pathogenesis of Tourette syndrome.
the N400I variant of SLITRK1 may have a role in obsessive-compulsive disorder
The study of chromosomal aberrations in Tourette syndrome etiology has implicated multiple genes, with SLITRK1 being the most prominent example.
One of the few genes that has been linked to TS is the SLITRK1 (Slit and Trk (show NTRK1 Proteins)-like 1) gene, where four variations have been suggested as possible disease-associated changes
DM1 motoneuron/muscle cell cocultures showed alterations that are consistent with the known role of SLITRK genes in neurite outgrowth, neuritogenesis, and synaptogenesis; functional defects can be directly attributed to SLITRK misexpression.
The study of this study support that SLITRK1 var321 is association to Tourette syndrome.
findings support the association of rare SLITRK1 sequence variants with Tourette's syndrome
SLITRK1 trouble in Tourette's syndrome.
Rare variations in SLITRK1 result in disorders of the obsessive-complusive disease spectrum
negative results of the SLITRK1 analysis point to genetic heterogeneity in Tourette syndrome
These results lead us to conclude that noradrenergic mechanisms are involved in the behavioral abnormalities of Slitrk1-deficient mice. Elevated anxiety due to Slitrk1 dysfunction may contribute to the pathogenesis of neuropsychiatric diseases
Data show that the expression of SLITRK1 is dynamic and specifically associated with the circuits most commonly implicated in TS and related disorders, suggesting that SLITRK1 contributes to the development of corticostriatal-thalamocortical circuits.
This intronless gene encodes a member of the SLITRK protein family. These proteins are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. The protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome.
SLIT and NTRK-like protein 1
, SLIT and NTRK-like family, member 1
, slit and trk like 1 protein
, leucine-rich repeat-containing protein 12
, slit and trk like gene 1