SMAD, Mothers Against DPP Homolog 5 Proteins (SMAD5)

The protein encoded by SMAD5 is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. Additionally we are shipping SMAD5 Antibodies (125) and SMAD5 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SMAD5 4090 Q99717
SMAD5 59328 Q9R1V3
SMAD5 17129 P97454
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Top SMAD5 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Baculovirus infected Insect Cells Mouse GST tag,His tag 100 μg Log in to see 14 to 16 Days
$437.80
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$672.00
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see Available
$284.90
Details
Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days
$3,305.50
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,305.50
Details
Yeast Orang-Utan His tag   1 mg Log in to see 60 to 71 Days
$3,305.50
Details
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
$3,309.17
Details

SMAD5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus)

Mouse (Murine) ,
,

More Proteins for SMAD, Mothers Against DPP Homolog 5 (SMAD5) Interaction Partners

Human SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. Smad5 acts as a intracellular pH messenger and maintains the bioenergetic homeostasis of cells by regulating cytoplasmic metabolic machinery.

  2. Differential expression of TGF-beta (show TGFB1 Proteins) superfamily members and role of Smad1 (show GARS Proteins)/5/9-signalling in chondral versus endochondral chondrocyte differentiation.

  3. Data suggest that differences in expression levels in granulosa-like tumor cells and granulosa cells (GCs (show GCLC Proteins)) from patients with polycystic ovary syndrome (PCOS) are due to increased expression of microRNA-27a-3p in GCs (show GCLC Proteins) caused by insulin (show INS Proteins) resistance in PCOS; microRNA-27a-3 expression is up-regulated in GCs (show GCLC Proteins) in PCOS; overexpression of miR (show MLXIP Proteins)-27a-3p inhibits SMAD5 expression and promotes apoptosis. (SMAD5 = SMAD family member 5)

  4. Here the involvement of the pathway in adult brain function is suggested. This exploratory study establishes a strategy to better identify neuronal molecular signatures that are potentially associated with mental illness and cognitive deficits. We propose that the SMAD (show SMAD1 Proteins) pathway may be a novel target in addressing cognitive deficit of SZ in future studies.

  5. the BMP-2 (show BMP2 Proteins)/Smad1 (show GARS Proteins)/5/RUNX2 (show RUNX2 Proteins) signaling pathway participates in the silicon-mediated induction of COL-1 and osteocalcin (show BGLAP Proteins) synth

  6. miR (show MLXIP Proteins)-23a and miR (show MLXIP Proteins)-27a target SMAD5 and regulate apoptosis in human granulosa cells via the FasL (show FASL Proteins)-Fas (show FAS Proteins) pathway

  7. Our findings suggest that suppression of miR (show MLXIP Proteins)-222-3p activity promoted osteogenic differentiation hBMSCs through regulating Smad5-RUNX2 (show RUNX2 Proteins) signaling axis.

  8. Overexpression of the BMP4 (show BMP4 Proteins)/SMAD4 (show SMAD4 Proteins)/SMAD5 signaling pathway could predict poor clinical outcome in skull base chordomas, suggesting activation of this pathway is involved in chordoma pathogenesis.

  9. The polycomb group protein L3MBTL1 (show L3MBTL1 Proteins) represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells.

  10. adult human Sertoli cells assumed similar morphological features, stable global gene expression profiles and numerous proteins, and activation of AKT (show AKT1 Proteins) and SMAD1 (show GARS Proteins)/5 during long-period culture.

Zebrafish SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway.

  2. Alk3 and Alk3b, as well as SMAD5, are essential cellular mediators of BMP signaling in zebrfish.

  3. Data show that interplay of Smad1 (show SMAD1 Proteins)/5 and MAP kinase (show MAPK1 Proteins) signaling system (ERK (show MAPK1 Proteins) signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.

  4. this study uncovers that smad1 (show SMAD1 Proteins) and smad9 (show SMAD9 Proteins) act redundantly to each other downstream of smad5 to mediate ventral specification and to regulate embryonic myelopoiesis.

  5. Functional investigation of a subset of these genes, fgf10a (show FGF10 Proteins), tgfb2 (show TGFB2 Proteins), pax9 (show PAX9 Proteins), and smad5 revealed their necessity in zebrafish palatogenesis.

  6. maternally supplied Smad5 is already required to mediate ventral specification prior to zygotic Bmp2 (show BMP4 Proteins)/7 signaling to establish the initial dorsoventral asymmetry

  7. Data show that patterning of the eye primordia in Smad5-deficient embryos starts during blastula and early gastrula stages.

  8. that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 (show SMAD1 Proteins) and Smad5.

  9. Data show that Smad5 expression is ubiquitous during testis development but becomes cell-specific in the adult.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).

Mouse (Murine) SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. SMAD5 is crucial for expanding amniotic ectoderm rapidly into a stretchable squamous sheet to accommodate exocoelom expansion, axial growth and folding morphogenesis.

  2. CD137 (show TNFRSF9 Proteins) signaling is a new regulator of angiogenesis by modulating the Smad1 (show SMAD1 Proteins)/5-NFATc1 (show NFATC1 Proteins) pathway.

  3. miR (show MLXIP Proteins)-155 inhibited osteoblast differentiation by downregulating the translation of SMAD5 in mouse preosteoblast cells. Inhibition of miR (show MLXIP Proteins)-155 promoted osteogenic potential and thus it can be used as a potential target in the treatment of bone defects.

  4. Up-regulation of miR (show MLXIP Proteins)-93 may contribute to the progression of morphine tolerance by targeting Smad5 in mouse model of bone cancer pain

  5. Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2 (show RUNX2 Proteins)) expression through S1PR2 (show S1PR2 Proteins)/RhoA (show RHOA Proteins)/ROCK/Smad1 (show SMAD1 Proteins)/5/8 signaling.

  6. We discovered that Smad1 (show SMAD1 Proteins)/5/4-Amhr2 (show AMHR2 Proteins)-cre KO females have malformed oviducts that subsequently develop oviductal diverticuli. In addition, uteri from Smad1 (show SMAD1 Proteins)/5/4-Amhr2 (show AMHR2 Proteins)-cre KO females exhibit multiple defects in stroma, epithelium, and smooth muscle layers and fail to assemble a closed uterine lumen upon embryo implantation, with defective uterine decidualization that led to pregnancy loss at early to mid-gestation.

  7. these studies characterize an accessory TGF-beta (show TGFB1 Proteins)-stimulated BMP R-Smad (show SMAD1 Proteins) signaling mechanism in interstitial cells of the developing lung.

  8. Thyroid-specific Smad1 (show SMAD1 Proteins) and Smad5 double-knockout (Smad1 (show SMAD1 Proteins)/5(dKO)) mice displayed growth retardation, hypothyroidism and defective follicular architecture.

  9. Smad1 (show SMAD1 Proteins) and Smad5 have overlapping functions to govern hepcidin (show HAMP Proteins) transcription. Moreover, erythropoietin (show EPO Proteins) and erythroferrone target Smad1 (show SMAD1 Proteins)/5 signaling and require Smad1 (show SMAD1 Proteins)/5 to suppress hepcidin (show HAMP Proteins) expression.

  10. miR (show MLXIP Proteins)-106b-5p and miR-17-5p are novel Smad5 regulators.

SMAD5 Protein Profile

Protein Summary

The protein encoded by this gene is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by BMP type 1 receptor kinase. Three transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with SMAD5

  • SMAD family member 5 (SMAD5)
  • SMAD family member 5 (Smad5)
  • SMAD family member 5 (smad5)
  • 1110051M15Rik protein
  • AI451355 protein
  • DKFZp468M0619 protein
  • Dwf-C protein
  • DWFC protein
  • fb67b04 protein
  • JV5-1 protein
  • mad protein
  • madh5 protein
  • MusMLP protein
  • sb:cb400 protein
  • SBN protein
  • SMAD5 protein
  • smd5 protein
  • wu:fb67b04 protein

Protein level used designations for SMAD5

MAD, mothers against decapentaplegic homolog 5 , SMA- and MAD-related protein 5 , SMAD, mothers against DPP homolog 5 , mothers against decapentaplegic homolog 5 , mothers against decapentaplegic, drosophila, homolog of, 5 , MAD homolog 5 , SMAD 5 , mothers against DPP homolog 5 , SMAD family member 5 , pgy , piggytail , somitabun , Mothers against decapentaplegic homolog 5 , Smad 5 , dwarfin-C , mSmad5

GENE ID SPECIES
4090 Homo sapiens
59328 Rattus norvegicus
395679 Gallus gallus
30641 Danio rerio
481520 Canis lupus familiaris
768050 Bos taurus
100033851 Equus caballus
100173534 Pongo abelii
100303615 Sus scrofa
17129 Mus musculus
100717571 Cavia porcellus
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