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Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. Additionally we are shipping SPHKAP Antibodies (8) and and many more products for this protein.
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Results showed that DPP6 (show DPP6 ELISA Kits), SPHKAP and ID4 (show ID4 ELISA Kits) were down regulated in acute myeloid leukemia (show BCL11A ELISA Kits) (AML (show RUNX1 ELISA Kits)) patients.
SKIP is an entirely specific type I A-kinase anchoring protein (show AKAP13 ELISA Kits) that can sequester two molecules of protein kinase A at mitochondria.
sphingosine kinase type 1-interacting protein can be considered as the first mammalian A-kinase-anchoring proteins that preferentially binds to regulatory subunit 1 of cAMP-dependent protein kinase.
cloning and characterization; results indicate that SKIP is a novel protein likely to play a regulatory role in the modulation of sphingosine kinase type 1 (SPHK1 (show SPHK1 ELISA Kits)) activity
experiments demonstrate that sphingosine kinase 1 (show SPHK1 ELISA Kits)/sphingosine-1-phosphate are important components of the transforming growth factor-beta signaling pathway involved in up-regulation of the tissue inhibitor of metalloproteinase-1 (TIMP-1)
Uterine expression of SphK1 (show SPHK1 ELISA Kits) mediates processes involved in growth and differentiation of uterine tissues during pregnancy.
Hyperglycemia stimulates SK1 activity via protein kinase C (show PKC ELISA Kits) and oxidative stress-dependent pathways, leading to decreased apoptosis in vvascular smooth muscle.
HIF-1 and HIF-2 have roles in SK1 upregulation during hypoxia in glioma cells
These results indicate that SKIP modulates GSIS by a pathway distinct from that of cAMP-, PDE- and sphingosine kinase-dependent pathways.
Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1.
A-kinase anchor protein SPHKAP
, SPHK1 (sphingosine kinase type 1) interacting protein
, SPHK1-interactor and AKAP domain-containing protein
, sphingosine kinase type 1-interacting protein