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SOX15 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. Additionally we are shipping SOX15 Antibodies (56) and SOX15 Kits (3) and many more products for this protein.
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SOX15 could regulate the proliferation and migration of endometrial cancer cells and up- regulation of SOX15 could be valuable for endometrial cancer treatment.
Increased expression of epithelial OCT4 (show POU5F1 Proteins), SOX15 and TWIST1 (show TWIST1 Proteins) was detected in endometriotic tissue compared to endometriosis patient endometrium. Epithelial expression of OCT4 (show POU5F1 Proteins), SOX15, and TWIST1 (show TWIST1 Proteins) was increased in the endometrium of endometriosis patients compared to controls.
Results indicate that the expression of SOX15 in pancreatic cancer cell lines with undetectable expression resulted in reduced viability of cancer cells both in vitro and in vivo demonstrating its tumor suppressive capability.
We established stable NT2/D1 cell lines overexpressing SOX15 (SOX15-NT2/D1), and a modified 3-(4,5-dime-thylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed that the SOX15-NT2/D1 cells exhibited significantly slower growth than controls
The gain of function studies indicated that sex-determining region Y (SRY (show SRY Proteins))-box 15 (SOX15) activate NR5A1 (show NR5A1 Proteins) gene expression.
Sox15 and Sox2 (show SOX2 Proteins) have distinct roles in transcriptional control in mouse ES cells
role in increasing Hand1 (show HAND1 Proteins) transcriptional activity might promote the transcription of the target gene resulting in the trophoblast giant cell differentiation in the mouse placenta
These studies demonstrate that Sox15, Fhl3 and Foxk1 function to coordinately regulate the myogenic progenitor cell population and skeletal muscle regeneration.
These results suggest that the region from -297 to -8 of the Sox15 gene contains three distinct cis (show CISH Proteins)-elements, and that these sequences were conserved among eutherian mammals during vertebrate evolution.
both Sox7 (show SOX7 Proteins) and Sox15 are able to induce the early stages of myogenesis, but only Sox7 (show SOX7 Proteins) is sufficient to initiate the formation of fully differentiated skeletal myocytes.
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.
SRY (sex determining region Y)-box 20
, protein SOX-15
, SRY-box containing gene 15