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SOX18 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. Additionally we are shipping SOX18 Antibodies (47) and SOX18 Kits (29) and many more products for this protein.
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The present data demonstrate that the endothelial-specific and lymph endothelial-specific transcription factors SOX18 and PROX1 (show PROX1 Proteins) contribute to lymph endothelial cells retraction
A novel mutation in the SOX18 gene identified in a patient with hypotrichosis-lymphedema-telangiectasia syndrome.
Results showed that on the contrary of the mRNA level, the protein levels of SOX18 were higher in lung adenocarcinoma (AC) cases compared to levels noted in the non-malignant lung tissues (NMLTs). The disparity between the mRNA and protein levels of the SOX18 transcription factor was caused by miR (show MLXIP Proteins)-7a and miR (show MLXIP Proteins)-24-3p, although the mechanism through which lung cancer cells downregulate miRNA molecule levels is still unclear.
miR-7 (show LILRB1 Proteins)-5p targeted SOX18 to inhibit gp130 (show IL6ST Proteins)/JAK2 (show JAK2 Proteins)/STAT3 (show STAT3 Proteins) signaling pathway to exert its suppressing role in Pancreatic ductal adenocarcinoma
Nuclear expression of SOX18 was shown in vascular endothelial cells, basal layer cells of NS epidermis, as well as in AK, BCC and SCC (show CYP11A1 Proteins) cancer cells
SOX18 plays a significant role in promoting the growth of pancreatic ductal adenocarcinoma, and might serve as a promising target for PDAC therapy
Study reports SOX18 as novel risk gene for Neural tube defects (NTDs) but findings also suggest that SOX18 hypomethylation and increased expression must interplay with other environmental and (epi (show TFPI Proteins))genetic factors that are causative for NTDs.
SOX18 was overexpressed in prostate cancer.SOX18 promotes prostate cancer progression via the regulation of TCF1 (show HNF1A Proteins), c-Myc (show MYC Proteins), cyclin D1 (show CCND1 Proteins) and MMP-7 (show MMP7 Proteins).
the results of this study suggest that knockdown of SOX18 inhibits breast cancer cell growth and invasion, possibly by downregulating downstream oncogenic proteins, providing novel insights into the development of breast cancer therapy through targeting of SOX18.
miRNAs interact with the mRNA of the SOX18 gene, but the mechanism by which they could be inhibited in cancer cells requires further examination
Here we demonstrate that VEGF (show VEGFA Proteins)-165 mediates MSC (show MSC Proteins) differentiation into ECs via VEGFR-2 (show KDR Proteins)-dependent induction of Sox18, which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype
Sox18 acts as a mesenchymal molecular switch necessary for the formation and function of the dermal papilla in all hair types.
combined deletion of Sox7 (show SOX7 Proteins), Sox17 (show SOX17 Proteins), and Sox18 at the onset of retinal angiogenesis leads to a dense capillary plexus with a nearly complete loss of radial arteries and veins, whereas the presence of a single Sox17 (show SOX17 Proteins) allele largely restores arterial identity
Sox18 genetically interacts with VegfC (show VEGFC Proteins) to regulate lymphangiogenesis in Zebrafish.
SOX18 induction is a key step in mediating tumor lymphangiogenesis and metastasis
Overexpression of wild-type SOX18 promoted capillary tube formation of HUVECs in vitro, whereas expression of dominant-negative SOX18 impaired tube formation of HUVECs and the migration of MCF-7 cells via the disruption of the actin cytoskeleton.
Results indicate that Sox17 (show SOX17 Proteins) and Sox18, and possibly all three SoxF genes, are cooperatively involved in mammalian vascular development.
These result can explain previously controversial data on the functional consequences of Sox18 mutations in mice and humans.
Sox17 (show SOX17 Proteins)/Sox18 double-null embryos showed more severe defects in formation of anterior dorsal aorta and head/cervical microvasculature, and in some cases, aberrant differentiation of endocardial cells and defective fusion of the endocardial tube
findings demonstrate a critical role for Sox18 in developmental lymphangiogenesis, and suggest new avenues to investigate for therapeutic management of human lymphangiopathies
SOX18 plays role in the vascular dysfunction in hypotrichosis-lymphedema-telangiectasia syndrome.
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.
, transcription factor SOX-18
, SRY-box containing gene 18
, Sry-related HMG-box gene 18