SRY (Sex Determining Region Y)-Box 21 Proteins (SOX21)

SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). Additionally we are shipping SOX21 Antibodies (48) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SOX21 11166 Q9Y651
SOX21 223227 Q811W0
Rat SOX21 SOX21 306168  
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Top SOX21 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days
$2,607.00
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Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$2,678.50
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Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
$2,735.33
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SOX21 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for SRY (Sex Determining Region Y)-Box 21 (SOX21) Interaction Partners

Human SRY (Sex Determining Region Y)-Box 21 (SOX21) interaction partners

  1. SOX21-AS1 could be a potential prognostic biomarker .

  2. The tumorigenic effect of lncRNA SOX21-AS1 (show PTGDR Proteins) in CRC (show CALR Proteins) cells via targeting miR (show MLXIP Proteins)-145/MYO6 (show MYO6 Proteins), providing a novel insight for CRC (show CALR Proteins) carcinogenesis.

  3. Tumors originating from glioma cells with an induced expression of Sox21 exhibited an increased formation of Sox2 (show SOX2 Proteins):Sox21 complexes and an upregulation of S100beta, CNPase (show CNP Proteins) and Tuj1

  4. suggest that Sox21 can negatively regulate Sox2 (show SOX2 Proteins) in glioma. Our findings imply that Sox2 (show SOX2 Proteins) and Sox21 may be interesting targets for the development of novel glioma therapy

Mouse (Murine) SRY (Sex Determining Region Y)-Box 21 (SOX21) interaction partners

  1. the expression of Sox21 in hypothalamic-pituitary development was examined.

  2. Low SOX21 expression is associated with Glioma.

  3. Following elevation of the palatal shelves (E14.5), Sox2 (show SOX2 Proteins), Sox11 (show SOX11 Proteins) and Sox21 expression was present in the midline epithelial seam. We thus identify dynamic spatio-temporal expression of Sox (show QSOX1 Proteins) gene family during the process of palatogenesis

  4. Study identifies CARM1 (show CARM1 Proteins), which methylates histone H3 (show HIST3H3 Proteins) at arginine 26 (H3R26), as an upstream regulator of Sox21 expression. These results indicate that heterogeneity in gene expression patterns biases cell fate in the mouse embryo as early as the 4-cell stage.

  5. results implicate Sox21 specifically in the promotion of spongiotrophoblast and giant cell differentiation and establish a new mechanism through which trophoblast sublineages are specified

  6. The effects of Sox21 gene deletion on hair lipids have been studied.

  7. results show that transcriptional induction of Sox21 is a rapid and general mediator of the effects of Sox2 (show SOX2 Proteins) on cell identity in a wide range of cell types

  8. Sox21 repressed Hes5 (show HES5 Proteins) gene expression at the transcriptional level in hippocampus adult neurogenesis.

  9. Sox21, a counteracting partner of the SoxB1 family, controls fine-tuned cell fate decisions

  10. Findings suggest that bivalent genes, such as Sox21, are silenced by a complex set of redundant repressive machinery, which exit rapidly in response to appropriate differentiation signals.

Xenopus laevis SRY (Sex Determining Region Y)-Box 21 (SOX21) interaction partners

  1. Sox21 regulates the progression of neuronal differentiation in a dose-dependent manner.

Fruit Fly (Drosophila melanogaster) SRY (Sex Determining Region Y)-Box 21 (SOX21) interaction partners

  1. We further demonstrate that JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling, Sox21a and GATAe form a functional relay to orchestrate EB differentiation. Thus, our study provides new insights into the complex and sequential events that are required for rapid differentiation following stem cell division during tissue replenishment.

  2. Sox21a is specifically required for adult intestinal stem cell proliferation.

  3. This study reports that loss of the SOX (show PIPOX Proteins) transcription factor, Sox21a, blocks the differentiation programme of enteroblast (EB), the intestinal stem cell progeny in the adult Drosophila midgut with subsequent tumor formation.

Zebrafish SRY (Sex Determining Region Y)-Box 21 (SOX21) interaction partners

  1. conserved non-coding elements at the vertebrate Sox21 locus are crucial for Sox21 expression in the embryonic lens and that loss of Sox21 function interferes with normal lens development

  2. Comparative analysis of duplicated sox21 genes in zebrafish.

  3. Sox21a acts as a repressor in dorso-ventral patterning.

SOX21 Protein Profile

Protein Summary

SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).

Gene names and symbols associated with SOX21

  • SRY-box 21 (SOX21)
  • SRY (sex determining region Y)-box 21 (Sox21)
  • SRY-box 21 S homeolog (sox21.S)
  • CG7345 gene product from transcript CG7345-RA (Sox21a)
  • SRY box 21 (Sox21)
  • SRY-box 21 (sox21)
  • SRY (sex determining region Y)-box 21a (sox21a)
  • SRY (sex determining region Y)-box 21b (sox21b)
  • CG7345 protein
  • CH31 protein
  • Dmel\\CG7345 protein
  • sox21 protein
  • sox25 protein
  • sox30 protein
  • Sox B2-3 protein
  • SoxB2.3 protein
  • SRY-box protein
  • zgc:110678 protein

Protein level used designations for SOX21

SOX-A , SRY-box 21 , transcription factor SOX-21 , DNA-binding protein SOX21 , HMG-box protein SOX21 , SRY-box containing gene 21 , transcription factor Sox-21 , CG7345-PA , CG7345-PB , Sox21a-PA , Sox21a-PB , SRY (sex determining region Y)-box 21 , SRY-box containing gene 25 , transcription factor Sox-21-A , SRY-box containing gene 21b , transcription factor Sox-21-B , SRY-related protein CH31 , Transcription factor SOX-21

GENE ID SPECIES
11166 Homo sapiens
223227 Mus musculus
100337612 Xenopus laevis
39567 Drosophila melanogaster
306168 Rattus norvegicus
100038091 Xenopus (Silurana) tropicalis
100304456 Oryzias latipes
30543 Danio rerio
614121 Bos taurus
406246 Danio rerio
107051027 Gallus gallus
100517115 Sus scrofa
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