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SOX5 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. Additionally we are shipping SOX5 Antibodies (51) and SOX5 Kits (3) and many more products for this protein.
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SOX5 overexpression increased Kruppel-like factor 4 (KLF4 (show KLF4 Proteins)) gene expression, which was decreased by SOX5 silencing. KLF4 (show KLF4 Proteins) knockdown abrogated the suppressive effect of SOX5 overexpression on osteogenic differentiation of hMSCs.
Results show that SOX5 expression levels is increased in the synovium of patients with rheumatoid arthritis (RA). Its overexpression regulates the expression of RANKL (show TNFSF11 Proteins) in RA synovial fibroblasts.
SOX5, candidate gene, associated with clinical features of Depression (e.g., earlier age at onset and recurrent and more severe forms of Depression). Gene expression patterns in the prefrontal and anterior cingulate cortex most closely matched the genetic findings.
SOX5 promoted epithelial-mesenchymal transition (EMT (show ITK Proteins)) by regulation of Snail (show SNAI1 Proteins).
Short-SOX5 regulates transcription of human SPAG16L gene via directly binding to the promoter of SPAG16L.
results suggest that lnc-Sox5, which was stabilized by HuR (show ELAVL1 Proteins), could regulate carcinogenesis of tongue cancer and may serve as a predicted target for tongue carcinoma therapies
Collectively, these findings indicate that SOX5 is a novel candidate gene for Alzheimer's disease(AD) with an important role in neuronal function. The genetic findings warrant further studies to identify and characterize SOX5 variants that confer risk for AD, amyotrophic lateral sclerosis and intellectual disability.
The results of the present study suggest a role for SOX5 in the molecular pathogenesis of FL.
SOX5 has a strong inhibitory effect on MITF (show MITF Proteins) expression and seems to have a decisive clinical impact on melanoma during tumor progression.
Our results indicate for the first time that SOX5 is a novel regulator of epithelial-mesenchymal transition in hepatocellular carcinoma
Data show that SRY-box containing gene 5 protein (Sox5) can physically bind to the collapsin response mediator protein 5 (CRMP5 (show DPYSL5 Proteins)) promoter DNA.
the novel role of Tgfb2 (show TGFB2 Proteins), Fbxl18 (show FBXL18 Proteins), and Tle3 in formation of Sox5, Sox6, and Sox9 (show SOX9 Proteins) dependent tissues.
Low SOX5 expression is associated with Glioma.
Study revealed that Sox5 and Sox6 prevent oligodendroglial differentiation, thus ensuring that the progenitor cells first reach their proper destination and only then lose their migratory capacity
This study demonstrated that Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes.
Results show that Sox9 (show SOX9 Proteins), Sox5, and Sox13 (show SOX13 Proteins) transcription factors are expressed in postnatal testis and may regulate multiple functions such as steroidogenesis and spermatogenesis.
Results suggest that L-Sox5 protein expression may diminish along with the progress of chondrogenic differentiation. L-Sox5 may act as a negative regulator if expressed aberrantly at least in part by regulating the critical fate of chondrogenesis.
T cell-specific Sox5-deficient mice exhibit impaired Th17 cell differentiation and are resistant to experimental autoimmune encephalomyelitis and delayed-type hypersensitivity.
Sox5 regulates the proliferation of malignant B cells.
L-Sox5 and Sox6 proteins enhance chondrogenic miR (show MLXIP Proteins)-140 microRNA expression by strengthening dimeric Sox9 (show SOX9 Proteins) activity
These results demonstrate that C/T missense mutation within the SOX5 gene is involved in bull sperm quality.
The inhibitory function of Meox2 (show MEOX2 Proteins) and the pro-myogenic function of Sox5 were confirmed during Xenopus normal development by the use of translation-blocking oligomorpholinos and dexamethasone inducible chimeric Sox5 and Meox2 (show MEOX2 Proteins) proteins.
show that Sox5 is essential for activation of BMP target genes in embryos and explants, that it physically interacts with BMP R-Smads
findings reveal surprising diversity in even the mode of the interactions between Sox5 and Sox10 (show SOX10 Proteins) governing specification of pigment cell types in medaka and zebrafish, and suggest that this is related to the evolution of a fourth pigment cell type
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
transcription factor SOX-5
, transcription factor LSox5-I
, SRY (sex determining region Y)-box 5
, Transcription factor Sox-5
, SRY-box containing gene 5
, SRY-box containing gene 5-like 1
, SRY-box 5
, SRY-related HMG-box 5 protein