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The protein encoded by ST8SIA2 is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins.
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Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4 (show ST8SIA4 ELISA Kits) have been described.
impairment of the regulated expression of ST8SIA2 and the resulting downstream effects on gene products by these two intronic single nucleotide polymorphism contribute to the development of these psychiatric disorders.
ST8SiaII role in the invasiveness and metastasis of small cell lung cancer cells
the relationships between psychiatric disorders and polySia and/or ST8SIA2
Data indicate a possible role of STX polysialyltransferase (show ST8SIA4 ELISA Kits) (ST8SIA2) in the common susceptibility of schizophrenia and bipolar I disorder (BD-I).
Our study showed interesting sex-specific associations between ST8SIAII and schizophrenia.
the role of ST8SIA2 sequence variation affecting polysialic acid-NCAM (show NCAM1 ELISA Kits) formation in 48 Caucasian cases with bipolar disorder
translational modification of the neural cell adhesion molecule NCAM (show NCAM1 ELISA Kits) and the polysialyltransferase (show ST8SIA4 ELISA Kits) ST8SiaII in mammalian semen involves polysialic acid
Expression of ST8SIA2 in omental fat at baseline was significantly associated with weight loss after Roux-en-Y gastric bypass.
that variation the ST8SIA2 gene is associated with increased risk to mental illness
Results demonstrate that the early development of calbindin (show CALB1 ELISA Kits)-positive periglomerular interneurons depends on the presentation of polysialic acid on NCAM (show NCAM1 ELISA Kits) and requires the activity of both St8sia2 and St8sia4 (show ST8SIA4 ELISA Kits)
NCAM (show NCAM1 ELISA Kits)-140 significantly promoted cell proliferation, motility and migration, while polysialylation of NCAM (show NCAM1 ELISA Kits)-140 catalyzed by STX enhanced NCAM (show NCAM1 ELISA Kits)-mediated cell migration, but not cell proliferation or motility.
These results reveal that reduced polysialylation in St8sia2 (-/-) mice leads to pathological brain development and schizophrenia-like behavior.
This study demonstrated that St8sia2 deficiency plus juvenile cannabis exposure in mice synergistically affect higher cognition in adulthood.
Results indicate that the polySTs ST8SiaII and ST8SiaIV (show ST8SIA4 ELISA Kits) not only recognize an acidic patch in the FN1 (show FN1 ELISA Kits) domain of NCAM (show NCAM1 ELISA Kits) but also must contact sequences in the Ig5 domain for polysialylation of Ig5 N-glycans to occur.
Polysialylation of the synaptic cell adhesion molecule (show CADM1 ELISA Kits) 1 (SynCAM 1 (show CADM1 ELISA Kits)) depends exclusively on the polysialyltransferase (show ST8SIA4 ELISA Kits) ST8SiaII in vivo.
results suggest that the ST8Sia5 gene increases ganglioside GQ1b and improves neuronal differentiation via the ERK1/2 (show MAPK1/3 ELISA Kits) MAP kinase (show MAPK1 ELISA Kits) pathway
While both ST8SiaII and ST8SiaIV (show ST8SIA4 ELISA Kits) mRNA levels decrease around the time of eye opening in mouse visual cortex, only ST8SiaII mRNA level reduction is regulated by sensory experience
At the mRNA level, the expression of GAD67 (show GAD1 ELISA Kits) and of St8SiaII was significantly reduced by chronic stress in the amygdala of adult mice.
ST8sia2 knockout mice displayed both decreased social motivation and increased aggressive behavior not explained by olfactory deficits. They displayed reduced anxiety-like behavior, increased locomotion and stress-induced corticosterone secretion.
The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29.
, alpha-2,8-sialyltransferase 8B
, sialyltransferase 8
, alpha-2,8-sialyltransferase 8B 1
, sialyltransferase 8 (alpha-2, 8-sialytransferase) B
, sialyltransferase 8B
, sialyltransferase St8Sia II
, sialyltransferase X
, sialytransferase St8Sia II
, polysialic acid synthase
, sialyltransferase 8 (alpha-2, 8-sialyltransferase) B
, ST8Sia II
, sialyltransferase 8 (alpha-2 8-sialytransferase) B