ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 Proteins (ST8SIA4)

The protein encoded by ST8SIA4 catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). Additionally we are shipping ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 Antibodies (45) and ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ST8SIA4 20452 Q64692
ST8SIA4 7903 Q92187
Rat ST8SIA4 ST8SIA4 116696  
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Top ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,355.45
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,979.17
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Yeast Chimpanzee His tag   1 mg Log in to see 60 to 71 Days
$2,979.17
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Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 6 to 10 Days
$284.90
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ST8SIA4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
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Human , ,
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More Proteins for ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 (ST8SIA4) Interaction Partners

Mouse (Murine) ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 (ST8SIA4) interaction partners

  1. Mice deficient for ST8SiaIV have impaired long-term spatial memory in two tasks that critically rely on the hippocampus.

  2. Results demonstrate that the early development of calbindin (show CALB1 Proteins)-positive periglomerular interneurons depends on the presentation of polysialic acid on NCAM (show NCAM1 Proteins) and requires the activity of both St8sia2 (show ST8SIA2 Proteins) and St8sia4

  3. NCAM (show NCAM1 Proteins)-140 significantly promoted cell proliferation, motility and migration, while polysialylation of NCAM (show NCAM1 Proteins)-140 catalyzed by STX (show ST8SIA2 Proteins), but not by PST, enhanced NCAM (show NCAM1 Proteins)-mediated cell migration, but not cell proliferation or motility.

  4. ST8SiaIV synthesized polySia selectively on a NRP2 (show NRP2 Proteins) glycoform that was characterized by the presence of sialylated core 1 and core 2 O-glycans.

  5. Results indicate that the polySTs ST8SiaII (show ST8SIA2 Proteins) and ST8SiaIV not only recognize an acidic patch in the FN1 (show FN1 Proteins) domain of NCAM (show NCAM1 Proteins) but also must contact sequences in the Ig5 domain for polysialylation of Ig5 N-glycans to occur.

  6. the negative and positive effects of ST8SiaIV overexpression observed during peripheral nerve regeneration suggest that an optimized time- and differentiation-dependent control of expression in Schwann cells may further improve nerve regeneration

  7. While both ST8SiaII (show ST8SIA2 Proteins) and ST8SiaIV mRNA levels decrease around the time of eye opening in mouse visual cortex, only ST8SiaII (show ST8SIA2 Proteins) mRNA level reduction is regulated by sensory experience

  8. ST8Sia4 knockout mice display a decreased motivation in social interaction. This deficit can be partly explained by olfactory deficits and was associated with a clear decrease in PSA (show NPEPPS Proteins)-NCAM (show NCAM1 Proteins) expression in all brain regions analyzed.

  9. This study demonistrated that mice lacking St8siaIV polysialyltransferase have an accelerated onset of remyelination after cuprizone-induced demyelination.

  10. In summary, the data suggest that the polysialic acid-neural cell adhesion molecule (show MCAM Proteins) system is a putative target for the modulation of

Human ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 (ST8SIA4) interaction partners

  1. Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 (show ST8SIA2 Proteins) and ST8SIA4 have been described.

  2. our results demonstrate that miR (show MLXIP Proteins)-146a and miR (show MLXIP Proteins)-146b promote proliferation, migration and invasion of FTC (show FUT2 Proteins) via inhibition of ST8SIA4.

  3. Data show that miR-181c was inversely correlated with the levels of ST8SIA4 expression in chronic myelocytic leukemia (CML) cell lines and samples.

  4. This is the first report to demonstrate a role for a glycosyltransferase (show GTDC2 Proteins) in human pluripotent stem cell lineage specification.

  5. changes in the glycosylation patterns and sialylation levels may be useful markers of the progression of breast cancer, as well as miR (show MLXIP Proteins)-26a/26b may be widely involved in the regulation of sialylation machinery by targeting ST8SIA4.

  6. The polybasic region of the polysialyltransferase ST8Sia-IV binds directly to NCAM (show NCAM1 Proteins).

  7. Sequence Requirements for Neuropilin-2 (show NRP2 Proteins) Recognition by ST8SiaIV and Polysialylation of Its O-Glycans.

  8. ST8SIA4 gene is involved in the development of multidrug resistance via PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway in chronic myeloid leukemia (show BCL11A Proteins).

  9. this study indicated that sialylation involved in the development of MDR of AML (show RUNX1 Proteins) cells probably through ST3GAL5 (show ST3GAL5 Proteins) or ST8SIA4 regulating the activity of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling and the expression of P-gp (show ABCB4 Proteins) and MRP1 (show MDM4 Proteins).

  10. ST8SiaIV synthesized polySia selectively on a NRP2 (show NELL2 Proteins) glycoform that was characterized by the presence of sialylated core 1 and core 2 O-glycans.

Pig (Porcine) ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 (ST8SIA4) interaction partners

  1. Pig cDNA provides a basis for uncovering the roles of ST8Sia IV during piglet development and maturation.

ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 4 (ST8SIA4) Protein Profile

Protein Summary

The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ST8SIA4

  • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 (St8sia4)
  • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 (ST8SIA4)
  • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 (st8sia4)
  • pst protein
  • PST-1 protein
  • PST1 protein
  • SIAT8-D protein
  • siat 8D protein
  • SIAT8D protein
  • ST8Sia-IV protein
  • ST8SiaIV protein

Protein level used designations for ST8SIA4

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase , alpha-2,8-sialyltransferase 8D , polysialyltransferase-1 , sialyltransferase 8 (alpha-2, 8-sialyltransferase) D , sialyltransferase 8D , sialyltransferase St8Sia IV , sialytransferase St8Sia IV , CMP-N-acetylneuraminate-poly-alpha-2,8-sialyl transferase , SIAT8-D , ST8SiaIV , sialyltransferase 8 (alpha-2, 8-polysialytransferase) D , ST8Sia IV , polysialyltransferase , sialyltransferase 8 (alpha-2 8-polysialyltransferase) D , sialyltransferase 8 (alpha-2 8-polysialytransferase) D , sialyltransferase 8 (alpha-2, 8-polysialyltransferase) D , sialyltransferase 8 (alpha-2, 8-sialytransferase) D , sialyltransferase 8D (alpha-2, 8-polysialyltransferase) , alpha-2,8-polysialyltransferase IV , polysialyltransferase 1 , N-glycan alpha 2,8-sialyltransferase , alpha-2,8-sialyltransferase ST8Sia IV , CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase-like protein

GENE ID SPECIES
20452 Mus musculus
7903 Homo sapiens
407768 Bos taurus
116696 Rattus norvegicus
374155 Gallus gallus
488886 Canis lupus familiaris
641356 Sus scrofa
461971 Pan troglodytes
101112314 Ovis aries
100716689 Cavia porcellus
553211 Danio rerio
100064780 Equus caballus
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