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SENP8 encodes a cysteine protease that is a member of the sentrin-specific protease family. Additionally we are shipping SUMO/sentrin Specific Peptidase Family Member 8 Antibodies (64) and SUMO/sentrin Specific Peptidase Family Member 8 Kits (1) and many more products for this protein.
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mutants of a DEN1 homolog from Arabidopsis thaliana have no detectable defects in NEDD8 processing but do accumulate a broad range of NEDD8 conjugates. Neddylation may serve as a regulatory mechanism for cullin and non-cullin proteins. [DEN1]
Furthermore, the authors characterized SENP8/DEN1 as the protease that counteracts Ubc12 (show ube2m Proteins) auto-neddylation, and observed aberrant neddylation of Ubc12 (show ube2m Proteins) and other NEDD8 (show NEDD8 Proteins) conjugation pathway components in SENP8-deficient cells.
In endothelial dysfunction, HDAC2 (show HDAC2 Proteins) levels were reciprocally regulated by ectopic expression of NEDD8 (show NEDD8 Proteins) and the de-NEDDylating enzyme SENP8.
the expression of SENP8, SAE1 (show SAE1 Proteins), PIAS1 (show PIAS1 Proteins), PIAS2 (show PIAS2 Proteins) and ZMIZ1 is deregulated in the majority of PTC (show F9 Proteins) tissues, likely contributing to the PTC (show F9 Proteins) phenotype.
Data indicate that overexpression of SENP8, a NEDD8 (show NEDD8 Proteins)-specific cysteine protease (show CTSB Proteins), resulted in deNEDDylation of E2F1 (show E2F1 Proteins) and promoted its transactivation activity at the p73 (show TP73 Proteins) gene.
We analyzed whether CSN1 (show CSN1S1 Proteins) alone can increase DEN1 degradation in HeLa cells.these data suggest that the COP9 (show COPS8 Proteins) signalosome supports proteasome-dependent protein degradation of DEN1/DenA in fungi and in human cells.
A role for SENP8 as a central regulator of the inflammatory process is identified using knockdown and overexpression approaches.
the specificity of NEDD8 (show NEDD8 Proteins)-specific peptidase SENP8
Data show that the stability of MDM2 (show MDM2 Proteins) is regulated by NEDD8 (show NEDD8 Proteins) pathway and identify NEDP1 that deneddylates MDM2 (show MDM2 Proteins), resulting in MDM2 (show MDM2 Proteins) destabilization concomitant with p53 (show TP53 Proteins) activation.
NEDP1 is likely to play an important role in ubiquitin-mediated proteolysis by controlling the activity of SCF (show KITLG Proteins) complexes
results suggest a unique role for NEDD8-specific protease 1(DEN1) in regulating the modification of cullin 1 (show CUL1 Proteins) by Nedd8 (show NEDD8 Proteins) protein
This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.
SUMO/sentrin specific peptidase family member 8
, NEDD8-specific protease 1
, SUMO/sentrin specific protease 8
, SUMO/sentrin specific protease family member 8
, protease, cysteine, 2 (NEDD8 specific)
, sentrin-specific protease 8
, sentrin/SUMO-specific protease SENP8
, NEDD8 specific-protease cysteine 2
, SUMO sentrin specific protease family member 8
, deneddylase 1
, protease, cysteine 2
, SUMO/sentrin specific peptidase 8
, Sumo1/sentrin/SMT3 specific peptidase 8