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Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Additionally we are shipping SIK2 Antibodies (97) and SIK2 Kits (10) and many more products for this protein.
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The results suggest that activation of SIK2 is required for the cell viability when proteasome activity is inhibited by peritoneal dialysis solutions.
Data demonstrate that SIK2 and SIK3 mRNA are downregulated in adipose tissue from obese individuals and that the expression is regulated by weight change. SIK2 is also negatively associated with in vivo insulin (show INS Proteins) resistance (HOMA-IR), independently of BMI and age.
Activated SIK2 plays a dual role in augmenting AMPK (show PRKAA1 Proteins)-induced phosphorylation of acetyl-CoA carboxylase and in activating the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathway through p85alpha-S154 phosphorylation. These findings identify SIK2 at the apex (show APEX1 Proteins) of the adipocyte-induced signaling cascades in cancer cells.
Findings suggest that SIK2 restricts autophagic flux which in the claudin-low subtype is essential for viability of triple-negative breast cancer cells.
Data show that microRNA miR (show MLXIP Proteins)-203 and the salt-inducible kinase 2 (SIK2) are reverse expressed in colorectal tumors.
Examination of SIK2 in prostate cancer cells found that it functions both as a positive regulator of cell-cycle (show C13orf15 Proteins) progression and a negative regulator of CREB1 (show CREB1 Proteins) activity. Also, the study shows high levels of auto-antibodies against SIK2 in plasma.
this study suggests that the tightly linked regulatory loop comprised of the SIK2-PP2A (show PPP2R4 Proteins) and CaMKI (show CAMK1 Proteins) and PME-1 (show PPME1 Proteins) networks may function in fine-tuning cell proliferation and stress response.
a mechanism by which the interplay between SIK2 and p97/VCP (show vcp Proteins) contributes to the regulation of ERAD in mammalian cells.
These findings revealed a new function of LKB1 (show STK11 Proteins) and salt-inducible kinases as negative regulators of HTLV-1 transcription.
tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases
SIK-2 participates in inflammation induction after ICH (show ACE Proteins). SIK-2 inhibition via Bosutinib or small interfering RNA decreased inflammation, attenuating brain injury. SIK-2 effects are, at least partly, mediated by CRTC3 (show CRTC3 Proteins)-cyclic amp-response element binding protein-NF-kappaB (show NFKB1 Proteins) signaling pathway.
Data, including data from studies conducted with knockout mice, suggest that Pin1 (show PIN1 Proteins) (prolyl isomerase 1) expression in pancreatic beta-cells is markedly elevated in obesity from diet high in fat/sucrose; Pin1 (show PIN1 Proteins) appears to be involved in proliferation of beta-cells and in regulation of secretion of insulin (show INS Proteins); Pin1 (show PIN1 Proteins) interacts with Sik2 (salt-inducible kinase 2) to regulate calcium signaling.
The data highlight an integral role for SIK2 and SIK3 in innate immunity by preventing the differentiation of macrophages into a potent and stable anti-inflammatory phenotype.
SIK2 acts directly on CRTC2 (show CRTC2 Proteins), CRTC3 (show CRTC3 Proteins) and HDAC4 (show HDAC5 Proteins), and the cAMP-PKA pathway reduces the interaction of SIK2 with CREB (show CREB1 Proteins)-regulated transcription co-activators and PP2A (show PPP2R2B Proteins). Downstream, SIK2 increases GLUT4 (show SLC2A4 Proteins) levels and glucose uptake in adipocytes.
Sik1, Sik2, and Sik3 play a key role as gluconeogenesis suppressors downstream of LKB1 (show STK11 Proteins) in the liver.
Data suggest that SIK2 is critical in regulating whole-body glucose metabolism primarily by controlling the CRTC2 (show CRTC2 Proteins)-CREB (show CREB1 Proteins) function of the white adipocytes.
The SIK2-p35 (show CDK5R1 Proteins)-PJA2 (show PJA2 Proteins) complex is essential for glucose homeostasis and provides a link between p35 (show CDK5R1 Proteins)-CDK5 (show CDK5 Proteins) and the AMPK (show PRKAA1 Proteins) family in excitable cells.
These findings suggest that SIK2 plays critical roles in neuronal survival, is modulated by CaMK (show CAMK2G Proteins) I/IV, and regulates CREB (show CREB1 Proteins) via TORC1 (show CRTC1 Proteins).
SIK2 represses eumelanogenesis in mice.
Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
, SNF1-like kinase 2
, qin-induced kinase
, salt-inducible protein kinase 2
, salt-inducible serine/threonine kinase 2
, serine/threonine-protein kinase SIK2
, serine/threonine-protein kinase SNF1-like kinase 2
, salt-inducible kinase 2
, salt induceable kinase 2