Sarcoglycan, alpha (50kDa Dystrophin-Associated Glycoprotein) Proteins (SGCA)

SGCA encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Additionally we are shipping SGCA Antibodies (57) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SGCA 6442 Q16586
SGCA 20391 P82350
Rat SGCA SGCA 303468  
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Top SGCA Proteins at antibodies-online.com

Showing 7 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
$560.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human SGCa Protein. 100 μg Log in to see 11 to 18 Days
$540.11
Details
Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$2,691.33
Details

SGCA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , , ,
Mouse (Murine)
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More Proteins for Sarcoglycan, alpha (50kDa Dystrophin-Associated Glycoprotein) (SGCA) Interaction Partners

Human Sarcoglycan, alpha (50kDa Dystrophin-Associated Glycoprotein) (SGCA) interaction partners

  1. Pathogenic mutations were found in SGCA from Egyptian families with limb-girdle muscular dystrophy.

  2. IN TMD patients, a locus near the sarcoglycan alpha ( SGCA), rs4794106, was suggestive in the discovery analysis ( P = 2.6 x 10(6)) and replicated (i.e., 1-tailed P = 0.016) in the Brazilian cohort.

  3. The results suggest that the carrier rate of c.101G>T in SGCA may be high in Taiwan, especially in the aboriginal population regardless of the tribes.

  4. B4GAT1 is involved in the initiation of the LARGE-dependent repeating disaccharide that is necessary for extracellular matrix protein binding to O-mannosylated alpha-dystroglycan.

  5. Results show that HRD1 and RFP2 contributes are required for the disposal of V247M alpha-sarcoglycan mutant.

  6. 2 members of a Spanish family with muscular dystrophy had a new missense mutation c409G>A, p.Glu137Lys in exon 5 of the alpha-sarcoglycan gene, as well as a paternal c739G>A, p.Val24Met mutation inexon 6.

  7. DNA analysis demonstrated homozygosity for a point mutation (574C>T) in the alpha-sarcoglycan gene.

  8. E-cadherin,alpha-dystroglycan and beta-dystroglycan levels were decreased in the oesophageal primary tumour samples, despite the presence of normal levels of dystroglycan mRNA.

  9. This study reported recessive founder LGMD2D for the Magdalen Islands, an archipelago settled in the XIXth century, largely by Acadian immigrants.

  10. Reduced expression of laminin-binding glycans on alpha-DG may contribute to formation of highly infiltrative behavior of prostate carcinoma cells.

  11. Peptide sequences in alpha-DG are substrates for protein-O-mannose N-acetylglucosaminyltransferase 1 (POMGnT1), demonstrated when a library of mannopeptides is generated which corresponds to sequences of the mucin-like stem region of alpha-DG.

  12. Long-term, sustainable gene expression of alpha-sarcoglycan was observed following gene transfer mediated by AAV.

  13. Absence of members of the dystrophin-associated glycoprotein complex constitutes a permissive environment for spontaneous development of embryonal rhabdomyosarcoma associated with mutation of p53 and mutation or altered splicing of Mdm2.

  14. Two adult brothers with a mild form of LGMD2D, compound heterozygous for two missense mutations of the SGCA gene (Arg77Cys, Val247Met), presented with respiratory insufficiency while they were still ambulatory.

  15. Biglycan is a ligand for two members of the sarcoglycan complex and regulates their expression at discrete developmental ages.

  16. identified a negative regulatory element in the alpha-SG distal promoter including two conserved E-boxes (E1 and E2), which interact with MyoD

  17. The limb-girdle muscular dystrophy patients with alpha-sarcoglycan deficient LGMD2D do not enable an accurate prediction of the genotype.

SGCA Protein Profile

Protein Summary

This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SGCA

  • sarcoglycan alpha (SGCA)
  • sarcoglycan, alpha (dystrophin-associated glycoprotein) (Sgca)
  • sarcoglycan, alpha (Sgca)
  • 50-DAG protein
  • 50DAG protein
  • A2 protein
  • adhalin protein
  • ADL protein
  • Asg protein
  • DAG2 protein
  • DMDA2 protein
  • LGMD2D protein
  • SCARMD1 protein
  • Sgca protein

Protein level used designations for SGCA

50 kDa dystrophin-associated glycoprotein , 50DAG , adhalin , alpha-SG , alpha-sarcoglycan , dystroglycan-2 , 50kD DAG , sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)

GENE ID SPECIES
100009178 Oryctolagus cuniculus
6442 Homo sapiens
20391 Mus musculus
303468 Rattus norvegicus
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