Sarcoglycan, gamma (35kDa Dystrophin-Associated Glycoprotein) Proteins (SGCG)

SGCG encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. Additionally we are shipping Sarcoglycan, gamma (35kDa Dystrophin-Associated Glycoprotein) Antibodies (44) and and many more products for this protein.

list all proteins	Gene Name	GeneID	UniProt
	SGCG	6445	Q13326
	SGCG	24053	P82348
Rat SGCG	SGCG	305941

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Top Sarcoglycan, gamma (35kDa Dystrophin-Associated Glycoprotein) Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No.	Origin	Source	Conjugate	Quantity	Supplier	Delivery	Price	Details
ABIN3121065	Insect Cells	Mouse	rho-1D4 tag	0.25 mg	Log in to see	50 to 55 Days	$5,355.45	Details
ABIN3121066	Escherichia coli (E. coli)	Mouse	His tag	1 mg	Log in to see	30 to 35 Days	$5,465.26	Details
ABIN3076801	Insect Cells	Human	His tag	1 mg	Log in to see	50 Days	$6,869.04	Details
ABIN1319808	Wheat germ	Human	GST tag	10 μg	Log in to see	11 to 12 Days	$414.29	Details
ABIN2731921	HEK-293 Cells	Human	Myc-DYKDDDDK Tag	20 μg	Log in to see	Available	$814.00	Details
ABIN1617342	Yeast	Cow	His tag	1 mg	Log in to see	60 to 71 Days	$2,588.67	Details
ABIN1638241	Yeast	Dog	His tag	1 mg	Log in to see	60 to 71 Days	$2,588.67	Details
ABIN1655880	Yeast	Golden Syrian Hamster	His tag	1 mg	Log in to see	60 to 71 Days	$2,588.67	Details

SGCG Proteins by Origin and Source

Origin	Expressed in	Conjugate
Human	, ,	, , ,
Mouse (Murine)	,	,

More product categories related to Sarcoglycan, gamma (35kDa Dystrophin-Associated Glycoprotein) Protein

More Proteins for Sarcoglycan, gamma (35kDa Dystrophin-Associated Glycoprotein) (SGCG) Interaction Partners

Human Sarcoglycan, gamma (35kDa Dystrophin-Associated Glycoprotein) (SGCG) interaction partners

This study showed that fifteen families were shown to carry SGCG variants in patient with early onset severe muscular dystrophy.
FADH2-dependent monooxygenase (SgcE6 and SgcC) that catalyzes the hydroxylation of a PCP (show PRCP Proteins)-tethered substrate
These results position archvillin (show SVIL Proteins) as a mechanically sensitive component of the dystrophin (show DMD Proteins) complex and demonstrate that signaling defects caused by loss of gamma-SG occur both at the sarcolemma and in the nucleus.
A report of two siblings with severe childhood onset limb-girdle muscular dystrophy type 2C supports the theory that the mutation G787A in the SGCG gene is a founder mutation.
Molecular epidemiologic methods were used to calculate the frequency of heterozygotes for this SGCG mutation in Moroccan newborns and to estimate the prevalence of LGMD2C in the Moroccan population.
Data suggest that an SNP in an intron of SGCG (rs9552911) is associated with type 2 diabetes [Genome-Wide Association Study in Sikh populations in India & Meta-Analysis]
The C allele of the c.-94C>G polymorphism in delta-sarcoglycan (show SGCD Proteins) is a risk factor for HCM, which is increased by the Amerindian component and can play an important role in the etiology and progression of disease in Mexican patients
four Greek Gypsy patients with limb girdle muscular dystrophy type 2C carried the same homozygous C283Y mutation in the gamma-sarcoglycan gene
The relative incidence of LGMD2C among Japanese Duchenne muscular dystrophy (show DMD Proteins)-like patients can be calculated as 1 in 161 patients suspected to have Duchenne muscular dystrophy (show DMD Proteins).
Clinical, histologic, and immunohistochemical characteristics of three children with limb-girdle muscular dystrophy type 2C. Two novel mutations in the gamma-sarcoglycan gene were present. We found phenotypic differences in two brothers.

Mouse (Murine) Sarcoglycan, gamma (35kDa Dystrophin-Associated Glycoprotein) (SGCG) interaction partners

Cleavage of beta-DG still occurred when both MMP-2 (show MMP2 Proteins) and MMP-9 (show MMP9 Proteins) were knocked out in gamma - sarcoglycan-deficient mice. The study found that up-regulation of MMP-14 (show MMP14 Proteins) is capable of cleaving beta-DG, and it may be involved in the pathogenesis of sarcoglycanopathy.
for MD research. The Sgcg(-/-) mice have a more severe phenotype than the mdx (show DMD Proteins) mice. Muscle function was assessed by plethysmography and echocardiography. Histologically the Sgcg(-/-) mice displayed increased fibrosis and variable fiber size.
These results position archvillin (show SVIL Proteins) as a mechanically sensitive component of the dystrophin (show DMD Proteins) complex and demonstrate that signaling defects caused by loss of gamma-SG occur both at the sarcolemma and in the nucleus.
This study supports a model where dystrophin (show DMD Proteins), but not the sarcoglycans, protects the cardiac myocyte against mechanical damage.
localization of gamma-SG does not require Tyr (show TYR Proteins)(6), but localization alone is insufficient for restoration of normal signal transduction patterns after mechanical perturbation
The limb, shoulder, and pelvic muscles of the gsg-/- mice exhibited progressive muscle hypertrophy and weakness with age, and the findings were similar to those seen in other mouse models for limb-girdle and Duchenne muscular dystrophy (show DMD Proteins).
In sarcoglycan (show SGCD Proteins) mutant mice, regionally increased cardiac NO was associated with hypersensitivity to carbachol and decreased sensitivity to adrenergic stimulation.
delta- and gamma-sarcoglycan prevent vascular spasm in coronary arteries and in vascular smooth muscle
sarcoglycan (show SGCD Proteins) and integrin alpha7beta1 have overlapping roles in mediating cytoskeletal-membrane-extracellular matrix interaction
Sarcoglycan gamma missense mutations affect sarcoglycan (show SGCD Proteins) complex assembly and/or localization to the cell surface and provide information on the molecular mechanisms underlying the effects of various sarcoglycan (show SGCD Proteins) mutations in muscular dystrophies.

Sarcoglycan, gamma (35kDa Dystrophin-Associated Glycoprotein) (SGCG) Protein Profile

Protein Summary

This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C).

Gene names and symbols associated with SGCG

sarcoglycan, gamma (sgcg)
sarcoglycan gamma (SGCG)
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) (SGCG)
sarcoglycan gamma (Sgcg)
sarcoglycan, gamma (dystrophin-associated glycoprotein) (Sgcg)
sarcoglycan, gamma (Sgcg)

35DAG protein
35kDa protein
5430420E18Rik protein
A4 protein
AI642964 protein
DAGA4 protein
DMDA protein
DMDA1 protein
gamma-SG protein
LGMD2C protein
MAM protein
SCARMD2 protein
SCG3 protein
TYPE protein
zgc:100924 protein

Protein level used designations for SGCG

gamma-sarcoglycan , 35 kDa dystrophin-associated glycoprotein , 35DAG , 35kD dystrophin-associated glycoprotein , gamma sarcoglycan , gamma-SG , sgcg gene for gamma-sarcoglycan , sarcoglycan, gamma (35kD dystrophin-associated glycoprotein)

GENE ID	SPECIES
445292	Danio rerio
6445	Homo sapiens
486043	Canis lupus familiaris
100272144	Sus scrofa
506155	Bos taurus
100009214	Oryctolagus cuniculus
101825067	Mesocricetus auratus
24053	Mus musculus
305941	Rattus norvegicus

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