Sarcospan (Kras Oncogene-Associated Gene) Proteins (SSPN)

SSPN encodes a member of the dystrophin-glycoprotein complex (DGC). Additionally we are shipping Sarcospan (Kras Oncogene-Associated Gene) Antibodies (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SSPN 8082 Q14714
SSPN 16651 Q62147
Rat SSPN SSPN 500364  
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Top Sarcospan (Kras Oncogene-Associated Gene) Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days

SSPN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Sarcospan (Kras Oncogene-Associated Gene) (SSPN) Interaction Partners

Human Sarcospan (Kras Oncogene-Associated Gene) (SSPN) interaction partners

  1. Our data suggest TWIST1 and SSPN to be the functionally relevant androgenetic alopecia genes at the 7p21.1 and 12p12.1 risk loci, respectively.

  2. When human SSPN is expressed at three-fold levels in mdx mice, this increase in adhesion complex abundance improves muscle membrane stability, preventing many of the histopathological changes associated with Duchenne muscular dystrophy

  3. Analysis of sarcospan as a candidate gene for congenital fibrosis of the extraocular muscles type 1.

  4. Frequent polymorphism of peroxisome proliferator activated receptor gamma gene in colorectal cancer containing wild-type K-ras gene.

  5. Sarcospan plays an important mechanical role in stabilizing the dystrophin-glycoprotein complex.

  6. crystal structure of Imp beta (127-876) in complex SPN1 (1-65) at 2.8-A resolution reveals that Imp beta adopts an open conformation, which is unique for a functional Imp beta/cargo complex, and resembles the conformation of the Imp beta/RanGTP complex

  7. decreased expression of sarcospan at the Fukuyama congenital muscular dystrophy myofiber surfaces.

  8. Human SSPN in transgegnic mice directly interacts with utrophin-glycoprotein comlpex and functions to stabilize utrophin protein without increasing utrophin transcription.

Mouse (Murine) Sarcospan (Kras Oncogene-Associated Gene) (SSPN) interaction partners

  1. An alternatively spliced isoform of sarcospan localizes to the sarcoplasmic reticulum in skeletal muscle. It is absent in Sgcd-/- skeletal muscle, a murine model for limb girdle muscular dystrophy 2F.

  2. these results demonstrate that SSPN overexpression is well tolerated in mdx mice and improves sarcolemma defects that underlie skeletal muscle and pulmonary dysfunction in Duchenne muscular dystrophy

  3. regulates cardiac isoproterenol response and prevents Duchenne muscular dystrophy-associated cardiomyopathy

  4. Sarcospan-mediated amelioration of muscular dystrophy in mouse model is dependent on the presence of both utrophin and alpha7beta1 integrin.

  5. SSPN is a necessary component of dystrophin and Utr function and that SSPN modulation of integrin signaling is required for extracellular matrix attachment and muscle force development.

  6. Sarcospan-null mice displayed delayed differentiation after cardiotoxin injury caused by loss of utrophin and Akt signaling

  7. Sspn is downregulated in brain during hypoxia. Knockdown of Sspn increased cultured cell death under hypoxia.

Sarcospan (Kras Oncogene-Associated Gene) (SSPN) Protein Profile

Protein Summary

This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two alternatively spliced transcript variants that encode different protein isoforms have been described.

Gene names and symbols associated with SSPN

  • sarcospan S homeolog (sspn.S)
  • sarcospan (SSPN)
  • sarcospan (Sspn)
  • DAGA5 protein
  • Krag protein
  • NSPN protein
  • RGD1559723 protein
  • SPN1 protein
  • SPN2 protein

Protein level used designations for SSPN

sarcospan (Kras oncogene-associated gene) , K-ras oncogene-associated protein , Kras oncogene-associated , kirsten-ras-associated protein , microspan , nanospan , kirsten-Ras-associated protein , sarcospan

495447 Xenopus laevis
708482 Macaca mulatta
8082 Homo sapiens
16651 Mus musculus
500364 Rattus norvegicus
613989 Bos taurus
100008714 Oryctolagus cuniculus
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