anti-Scavenger Receptor Class B, Member 2 (SCARB2) Antibodies

The protein encoded by SCARB2 is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Additionally we are shipping SCARB2 Proteins (16) and SCARB2 Kits (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCARB2 950 Q14108
SCARB2 12492 O35114
SCARB2 117106 P27615
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Top anti-SCARB2 Antibodies at antibodies-online.com

Showing 10 out of 82 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated ICC, IF, IHC (p), IP, IHC, WB Staining of LIMP II in rat infarctzone tissue using ABIN152898 with a DAB detection system. 0.1 mL Log in to see 7 to 9 Days
$516.98
Details
Chinese Hamster Rabbit Un-conjugated ICC, FACS, IF, IHC (p), IHC, WB Detection of SR-BII in Jurkat whole cell lysate using ABIN152881. Lane 1: 1:1000 Lane 2: 1:500 Lane 3: 1:100 Western Blot: SR-BII Antibody [ABIN152881] - Western blot analysis of SR-BII in 1. Human heart lysate 2. Mouse heart lysate 0.1 mL Log in to see 7 to 9 Days
$488.73
Details
Human Goat Un-conjugated IHC, ELISA, WB EB09295 (0.1µg/ml) staining of Human Cerebral Cortex lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.84
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged SCARB2 is approximately 0.1ng/ml as a capture antibody. 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with SCARB2 antibody ABIN461919 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Kidney (formalin-fixed, paraffin-embedded) stained with SCARB2 antibody ABIN461919 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB 50 μg Log in to see 11 to 14 Days
$484.00
Details
Cow Rabbit Un-conjugated IHC, IHC (p), WB 50 μg Log in to see 11 to 14 Days
$727.83
Details
Mouse Rabbit Un-conjugated ELISA   100 μg Log in to see 14 to 16 Days
$163.90
Details

Top referenced anti-SCARB2 Antibodies

  1. Dog (Canine) Polyclonal SCARB2 Primary Antibody for ICC, IF - ABIN152898 : Balreira, Gaspar, Caiola, Chaves, Beirão, Lima, Azevedo, Miranda: A nonsense mutation in the LIMP-2 gene associated with progressive myoclonic epilepsy and nephrotic syndrome. in Human molecular genetics 2008 (PubMed)
    Show all 11 Pubmed References

  2. Chinese Hamster Polyclonal SCARB2 Primary Antibody for ICC, FACS - ABIN152881 : Huby, Doucet, Dachet, Ouzilleau, Ueda, Afzal, Rubin, Chapman, Lesnik: Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues. in The Journal of clinical investigation 2006 (PubMed)
    Show all 12 Pubmed References

  3. Human Polyclonal SCARB2 Primary Antibody for ELISA, WB - ABIN1002736 : Fujita, Ezaki, Noguchi, Kono, Himeno, Kato: Isolation and sequencing of a cDNA clone encoding 85kDa sialoglycoprotein in rat liver lysosomal membranes. in Biochemical and biophysical research communications 1991 (PubMed)
    Show all 4 Pubmed References

  4. Polyclonal SCARB2 Primary Antibody for IF, IHC (p) - ABIN540307 : Zhang, Moor, Merkler, Liu, McLean: Regulation of alternative splicing of liver scavenger receptor class B gene by estrogen and the involved regulatory splicing factors. in Endocrinology 2007 (PubMed)
    Show all 3 Pubmed References

  5. Mouse (Murine) Polyclonal SCARB2 Primary Antibody for CyTOF, FACS - ABIN5500392 : Yamayoshi, Koike: Identification of a human SCARB2 region that is important for enterovirus 71 binding and infection. in Journal of virology 2011 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal SCARB2 Primary Antibody for ELISA, WB - ABIN541991 : Li, Fan, Jin, Su, An, Xu, Sun, Zhang, Meng, Gao, Kong, Jiang: Establishment of cell lines with increased susceptibility to EV71/CA16 by stable overexpression of SCARB2. in Virology journal 2013 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal SCARB2 Primary Antibody for WB - ABIN541733 : Gamp, Tanaka, Lüllmann-Rauch, Wittke, DHooge, De Deyn, Moser, Maier, Hartmann, Reiss, Illert, von Figura, Saftig: LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice. in Human molecular genetics 2003 (PubMed)
    Show all 3 Pubmed References

  8. Human Polyclonal SCARB2 Primary Antibody for IHC (p), WB - ABIN541724 : Knipper, Claussen, Rüttiger, Zimmermann, Lüllmann-Rauch, Eskelinen, Schröder, Schwake, Saftig: Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis. in The Journal of physiology 2006 (PubMed)
    Show all 3 Pubmed References

  9. Human Polyclonal SCARB2 Primary Antibody for IHC, ELISA - ABIN361195 : Murphy, Gysbers, Abbott, Tayebi, Kim, Sidransky, Cooper, Garner, Halliday: Reduced glucocerebrosidase is associated with increased ?-synuclein in sporadic Parkinson's disease. in Brain : a journal of neurology 2014 (PubMed)

More Antibodies against SCARB2 Interaction Partners

Zebrafish Scavenger Receptor Class B, Member 2 (SCARB2) interaction partners

  1. This work describes a novel function for the Scarb2 receptor as an essential glycoprotein for notochord development.

Human Scavenger Receptor Class B, Member 2 (SCARB2) interaction partners

  1. Crystal structure of a LIMP-2 luminal domain dimer with bound cholesterol and phosphatidylcholine is described. Binding of these lipids alters LIMP-2 from functioning as a glucocerebrosidase-binding monomer toward a dimeric state that preferentially binds anionic phosphatidylserine over neutral phosphatidylcholine.

  2. The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection.

  3. The findings identify SR-BII as a functional SAA receptor that mediates SAA uptake and contributes to its proinflammatory signaling via the MAPK-mediated signaling pathways.

  4. In this paper we provide an updated overview of the clinical and genetic features of SCARB2-related PME and on the functions of the LIMP2 protein [review]

  5. neutrophils are able to drive a macrophage activation that would regulate the increase in LIMP-2 expression during the early phase of Cer-induced acute pancreatitis

  6. Findings suggested that STX1B rs4889603, FAM47E rs6812193 and SCARB2 rs6825004 do not confer a significant risk for Parkinson's disease

  7. LIMPII was increased greater than twofold in urinary microvesicles obtained from patients with idiopathic membranous nephropathy compared to microvesicles of patients with idiopathic focal segmental glomerulosclerosis and normal controls.

  8. hSR-BII, and to a lesser extent hSR-BI, significantly increase LPS-induced inflammation and contribute to LPS-induced tissue injury in the liver and kidney, two major organs susceptible to LPS toxicity.

  9. Although hrGCase cellular uptake is independent of LIMP-2, its trafficking to the lysosomes is mediated by this receptor.

  10. SNCA and SCARB2 loci are also associated with dementia with Lewy bodies, after a study-wise Bonferroni correction, although these have a different association profile than the associations reported for the same loci in Parkinson's.

  11. a novel mutation in SCARB2 as a cause of progressive myoclonus epilepsy in China

  12. SCARB2 regulates TLR9-dependent IFN-I production of plasmacytoid dendritic cells

  13. Disease-causing cathepsin-F mutants fail to cleave LIMP-2. Our findings provide evidence that LIMP-2 represents an in vivo substrate of cathepsin-F with relevance for understanding the pathophysiology of type-B-Kufs-disease.

  14. Data indicate that scavenger receptor SCARB2 triggers uncoating of human enterovirus 71 (EV71) under low pH conditions.

  15. SCARB2 and PSGL-1 in human gastrointestinal tract, lung, and brain tissues correlated with the distribution of pathological changes seen in EV71 infection.

  16. In LIMP-2-deficient brains a significant reduction in GC activity led to lipid storage, disturbed autophagic/lysosomal function, and alpha-synuclein accumulation.

  17. The LIMP-2/SCARB2 binding sequences for enterovirus 71 and GCase are not similar, indicating that LIMP-2/SCARB2 may have multiple or overlapping binding sites with differing specificities.

  18. A novel SCARB2 mutation was indicated by reduced Beta-glucocerebrosidase activity in progressive myoclonus epilepsy.

  19. Mutations in LIMP-2, the specific receptor for glucocerebrosidase that is missing in Gaucher disease patients, substantially contribute to the pathology and heterogeneity of the disease. (Review)

  20. study of two Japanese siblings with late-onset progressive myoclonus epilepsy without renal failure having a novel homozygous SCARB2 mutation

Mouse (Murine) Scavenger Receptor Class B, Member 2 (SCARB2) interaction partners

  1. LIMP-2 facilitates transport of phospholipids into murine fibroblasts, with a strong substrate preference for phosphatidylserine.

  2. The findings identify SR-BII as a functional SAA receptor that mediates SAA uptake and contributes to its proinflammatory signaling via the MAPK-mediated signaling pathways.

  3. AP-3-dependent LB targeting is facilitated by protein/protein interaction between LIMP-2/SCARB2 and PRDX6 in vitro and in vivo

  4. Heterologous expression of the luminal domain of LIMP-2 in wild-type cells.

  5. In LIMP-2-deficient brains a significant reduction in GC activity led to lipid storage, disturbed autophagic/lysosomal function, and alpha-synuclein accumulation.

  6. absence of Limp-2 reduces inflammation in experimental crescentic glomerulonephritis with decreased macrophage and T-cell infiltration in the kidney.

  7. Limp-2 deficiency leads to a minor increase in circulating renin. Limp-2, however, is not required for acute or chronic stimulation of renin release.

  8. The SR-BII is involved in cholesterol ester uptake for steroidogenesis and spermatogenesis in the testis.

  9. The residues between 144 and 151 are critical for SCARB2 binding to VP1 of EV71 and seven residues from the human receptor could convert murine SCARB2, an otherwise inefficient receptor, to an efficient receptor for EV71 viral infection.

  10. The data suggest that tubular proteinuria in Limp-2(-/-) mice is due to failure of endosomes containing reabsorbed proteins to fuse with lysosomes in the proximal tubule of the kidney. Failure of proteolysis is a novel mechanism for tubular proteinuria.

  11. The coiled-coil structure of LIMP-2 is required for its interaction with beta-glucocerebrosidase.

  12. CD36 is not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ dendritic cells.

  13. CD36 is differentially expressed by CD8+ splenic dendritic cells but is not required for cross-presentation in vivo.

  14. Overexpression of LGP85 causes an enlargement of early endosomes and late endosomes/lysosomes. LGP85 may participate in reorganizing the endosomal/lysosomal compartments.

  15. SR-A and CD36 are responsible for the preponderance of modified LDL uptake in macrophages and that other scavenger receptors do not compensate for their absence

  16. LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice

  17. Our findings suggest an important role for LIMP2 in the control of the localization and the level of apically expressed membrane proteins such as KCNQ1, KCNE1 and megalin in the stria vascularis.

  18. Peritoneal macrophages isolated from SR-BI/BII-knockout mice demonstrated a 30% decrease in bacterial uptake when compared with macrophages from normal mice.

  19. Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy.

  20. These data support a role for LIMP-2 as the mannose-6-phosphate-independent trafficking receptor for beta-glucocerebrosidase.

SCARB2 Antigen Profile

Protein Summary

The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SCARB2

  • scavenger receptor class B, member 2a (scarb2a) antibody
  • scavenger receptor class B member 2 (SCARB2) antibody
  • scavenger receptor class B member 2 (scarb2) antibody
  • scavenger receptor class B, member 2 (Scarb2) antibody
  • 9330185J12Rik antibody
  • AMRF antibody
  • Cd36l2 antibody
  • chunp6914 antibody
  • EPM4 antibody
  • fi13c07 antibody
  • HLGP85 antibody
  • LGP85 antibody
  • LIMP-2 antibody
  • LimpII antibody
  • MLGP85 antibody
  • scarb2 antibody
  • SR-BII antibody
  • wu:fi13c07 antibody

Protein level used designations for SCARB2

CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 , CD36 antigen-like 2 , lysosome membrane protein 2 , scavenger receptor class B, member 2 , lysosome membrane protein 2-like , putative lysosomal integral membrane protein II , 85 kDa lysosomal membrane sialoglycoprotein , 85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2 , CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II) , LIMP II , lysosome membrane protein II

GENE ID SPECIES
192340 Danio rerio
422638 Gallus gallus
461239 Pan troglodytes
549311 Xenopus (Silurana) tropicalis
699990 Macaca mulatta
100026052 Monodelphis domestica
100455864 Pongo abelii
100190617 Taeniopygia guttata
100397594 Callithrix jacchus
100470627 Ailuropoda melanoleuca
100593903 Nomascus leucogenys
533177 Bos taurus
950 Homo sapiens
12492 Mus musculus
117106 Rattus norvegicus
478435 Canis lupus familiaris
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