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The protein encoded by SCEL is a precursor to the cornified envelope of terminally differentiated keratinocytes. Additionally we are shipping SCEL Antibodies (52) and many more products for this protein.
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Sciellin, SPRR3 (show SPRR3 Proteins), and periplakin (show PPL Proteins) transcripts were all upregulated (4.67-, 4.95-, 2.77-fold, respectively) by prolonged exposure to cyclic strain (24-72 h), but not at earlier time points.
VDUP1 (show TXNIP Proteins) and sciellin were more highly expressed in keratinocytes undergoing differentiation and colocalization of the proteins could be demonstrated
Single nucleotide polymorphisms were detected in both matching tumor and normal esophageal tissues but no disease-associated mutations suggesting that SCEL is not a major factor in esophageal squamous cell carcinogenesis.
We conclude that sciellin null mice had no structural anomalies and the transgenic mice did not act as a dominant-negative mutation.
The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined.