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SCX encodes a basic helix-loop-helix type transcription factor involved in mesoderm and heart valve formation.
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Deletion of Scx led to altered long bone properties and callus healing.
scleraxis was required for TGFbeta (show TGFB1 Antibodies)-induced fibronectin (show FN1 Antibodies) expression: TGFbeta (show TGFB1 Antibodies) lost its ability to induce fibronectin (show FN1 Antibodies) expression following scleraxis knockdown.
The phosphorylation sequence matched that targeted by Casein Kinase 2, and inhibition of this kinase activity disrupted the ability of scleraxis to modulate the expression of its target genes while also attenuating TGFbeta (show TGFB1 Antibodies)-induced expression of type I collagen and myofibroblast phenotype conversion marker genes
Cardiac fibroblast phenotype regulation by scleraxis.
scleraxis, a transcription factor critically involved in embryonic tendon development and formation, plays a pivotal role in the fate determination of mesenchymal stem cells towards tenocyte differentiation.
deletion of Scx led to impairments in enthesis structure.
several mRNAs are affected by alternative splicing events in the absence of Scx, suggesting additional roles in post-transcriptional modification.
Expression and function of scleraxis in the developing auditory system.
These studies identify an important role for Scx in regulating proteoglycans in embryonic and mature valve cells.
paratenon cells, which normally do not express Scx, respond to injury by turning on Scx and assembling matrix to bridge the defect
scleraxis is not only essential for embryonic stem cell differentiation into tenocytes but that it also has an active role in maintaining fetal tenocytes, which is then redundant in adult tenocytes.
This gene encodes a basic helix-loop-helix type transcription factor involved in mesoderm and heart valve formation. The encoded protein is expressed during embryonic development of tendons and ligaments. The gene product regulates collagen type I gene expression in cardiac fibroblasts and myofibroblasts, and it may play a role in myocardial remodeling. The protein is expressed in the scar area of the adult heart following myocardial infarction.
basic helix-loop-helix transcription factor scleraxis