anti-Scleraxis Homolog A (Mouse) (SCXA) Antibodies

SCXA encodes a basic helix-loop-helix type transcription factor involved in mesoderm and heart valve formation. Additionally we are shipping Scleraxis Homolog A (Mouse) Kits (7) and Scleraxis Homolog A (Mouse) Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SCXA 20289 Q64124
SCXA 642658 Q7RTU7
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Top anti-Scleraxis Homolog A (Mouse) Antibodies at

Showing 10 out of 32 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB SCXA Antibody (C-term) (ABIN654398) western blot analysis in mouse cerebellum tissue lysates (35 µg/lane). This demonstrates the SCXA antibody detected the SCXA protein (arrow). All lanes : Anti-SCXA Antibody (C-term) at 1:1000 dilution Lane 1: HACAT whole cell lysate Lane 2: U-2OS whole cell lysate Lane 3: MCF-7 whole cell lysate Lane 4: T47D whole cell lysate Lane 5: PC-3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 22 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:1000 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated EIA, WB Western blot analysis of SCXA Antibody (C-term) Cat.-No AP53819PU-N in Mouse cerebellum tissue lysates (35ug/lane). This demonstrates the SCXA antibody detected the SCXA protein (arrow). 0.4 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated IHC (p) Immunohistochemistry-Paraffin: SCX Antibody  - Staining of human pancreas shows strong granular cytoplasmic positivity in exocrine glandular cells. 100 μL Log in to see 10 to 13 Days
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 11 to 14 Days
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 11 to 16 Days
Human Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL Log in to see 11 to 14 Days
Human Rabbit APC ELISA, WB   200 μL Log in to see 11 to 14 Days
Human Rabbit PE ELISA, WB   200 μL Log in to see 11 to 14 Days
Human Rabbit HRP ELISA, WB   200 μL Log in to see 11 to 14 Days
Human Rabbit FITC ELISA, WB   200 μL Log in to see 11 to 14 Days

Top referenced anti-Scleraxis Homolog A (Mouse) Antibodies

  1. Human Polyclonal SCXA Primary Antibody for WB - ABIN654398 : Furumatsu, Shukunami, Amemiya-Kudo, Shimano, Ozaki: Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription. in The international journal of biochemistry & cell biology 2009 (PubMed)
    Show all 4 Pubmed References

More Antibodies against Scleraxis Homolog A (Mouse) Interaction Partners

Mouse (Murine) Scleraxis Homolog A (Mouse) (SCXA) interaction partners

  1. The absence of Scx results in a defect in progenitor differentiation into Scx-expressing tenocytes and tendon repair.

  2. These results highlighted the functional importance of both transient and persistent expression domains of Scx for proper integration of the musculoskeletal components.

  3. Deletion of Scx led to altered long bone properties and callus healing.

  4. scleraxis was required for TGFbeta-induced fibronectin expression: TGFbeta lost its ability to induce fibronectin expression following scleraxis knockdown.

  5. The phosphorylation sequence matched that targeted by Casein Kinase 2, and inhibition of this kinase activity disrupted the ability of scleraxis to modulate the expression of its target genes while also attenuating TGFbeta-induced expression of type I collagen and myofibroblast phenotype conversion marker genes

  6. Cardiac fibroblast phenotype regulation by scleraxis.

  7. deletion of Scx led to impairments in enthesis structure.

  8. several mRNAs are affected by alternative splicing events in the absence of Scx, suggesting additional roles in post-transcriptional modification.

  9. Expression and function of scleraxis in the developing auditory system.

  10. These studies identify an important role for Scx in regulating proteoglycans in embryonic and mature valve cells.

  11. paratenon cells, which normally do not express Scx, respond to injury by turning on Scx and assembling matrix to bridge the defect

  12. Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization.

  13. Findings suggest a modular model for bone development, involving a distinct pool of Sox9- and Scx-positive progenitor cells that form bone eminences under regulation of TGFbeta and BMP4 signaling

  14. the Scx(+)/Sox9(+) progenitor pool is a unique multipotent cell population that gives rise to tenocytes, ligamentocytes and chondrocytes for the establishment of the chondro-tendinous/ligamentous junction

  15. Scx and Id1 are involved in the BMP4-Smad1-SMA signal transduction pathway besides the TGFbeta1-Smad1-SMA signaling pathway and modulate phenotypic changes in MCs in diabetic nephropathy.

  16. Two proepicardial markers (Scleraxis and Semaphorin3D) were identified that genetically delineate heretofore uncharacterized proepicardial subcompartments.

  17. Mechanical signaling exerts an important influence on the expression of genes, namely scleraxis (Scx) and type I collagen, which play a role in determining the tendon phenotype.

  18. In addition to regulating the embryonic formation of limb tendons, scleraxis also appears to play an important role in the adaptation of adult tendons to physiological loading.

  19. Transforming growth factor-beta induces skeletal muscle atrophy and fibrosis through the induction of atrogin-1 and scleraxis.

  20. Scleraxis is required for differentiation of the stapedius and tensor tympani tendons of the middle ear.

Human Scleraxis Homolog A (Mouse) (SCXA) interaction partners

  1. Abnormal upregulation of HIF-2alpha served as a key switch to direct TSPCs differentiation into osteochondral-lineage rather than teno-lineage. Notably, Scleraxis (Scx), an essential tendon specific transcription factor, was suppressed on constitutive activation of HIF-2alpha and mediated the effect of HIF-2alpha on TSPCs fate decision.

  2. These studies identify an important role for Scx in regulating proteoglycans in embryonic and mature valve cells.

  3. Scleraxis was expressed in periodontal ligament cells, bone marrow cells, and gingival fibroblasts, and may play an important role in differentiation of periodontal ligament cells.

  4. High glucose inhibited osteogenetic differentiation of periodontal ligament cells and up-regulated Scleraxis expression.

  5. Scx and E47 might modulate the primary chondrogenesis by associating with the Sox9-related transcriptional complex, and by binding to the conserved E-box on Col2a1 promoter.

  6. collagen type I and several T/L-related proteoglycans were upregulated in hMSC-Scx cells

  7. Scleraxis thus appears to play a key role in the transcriptional regulation of type I collagen synthesis.

Scleraxis Homolog A (Mouse) (SCXA) Antigen Profile

Protein Summary

Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages (By similarity).

Gene names and symbols associated with SCXA

  • scleraxis (Scx) antibody
  • scleraxis bHLH transcription factor (SCX) antibody
  • BB114693 antibody
  • Bhlha41 antibody
  • bHLHa48 antibody
  • Scl antibody
  • SCX antibody

Protein level used designations for SCXA

basic helix-loop-helix transcription factor scleraxis , class II bHLH protein scleraxis , class A basic helix-loop-helix protein 41 , class A basic helix-loop-helix protein 48

20289 Mus musculus
374101 Gallus gallus
642658 Homo sapiens
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