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Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Additionally we are shipping Sclerostin Kits (67) and Sclerostin Proteins (21) and many more products for this protein.
Showing 10 out of 141 products:
Human Polyclonal Sclerostin Primary Antibody for EIA, IHC (p) - ABIN358751
Semenov, He: LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST. in The Journal of biological chemistry 2006
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Human Polyclonal Sclerostin Primary Antibody for IHC (p), WB - ABIN390193
Lin, Lin, Chang, Wang, Lai: Single-pulsed electromagnetic field therapy increases osteogenic differentiation through Wnt signaling pathway and sclerostin downregulation. in Bioelectromagnetics 2015
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In our cohort of pregnant women, sclerostin and DKK1 (show DKK1 Antibodies) were not associated with any adverse metabolic profile, and possibly do not play relevant roles in the pathophysiology of gestational diabetes mellitus.
Sclerostin increased after exercise in comparison to baseline (mean +/- SEM: 410 +/- 27 vs. 290 +/- 19 pg/mL; p < 0.001) corresponding to an increase of +44.3 +/-5.5%
serum sclerostin levels correlated positively with carotid intima-media thickness and inversely with the augmentation index, a marker of arterial stiffness
The difference of serum sclerostin levels in Ankylosing Spondylitis and Rheumatoid Arthritis patients was not significantly different from HC, indicating that the sclerostin may not associate with the development of Ankylosing Spondylitis and Rheumatoid Arthritis.
SOST gene silencing promotes the proliferation, invasion, and migration, and inhibits apoptosis of osteosarcoma cells by activating Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway
No difference was found in the serum sclerostin levels between the hyperthyroidism patients and healthy control.
Positivity of RANKL (show TNFSF11 Antibodies) and anti-CCP2 (show AGBL2 Antibodies) yielded significant risk for progression with negativity for both as reference. No single nucleotide polymorphism encoding TNFSF11 (show TNFSF11 Antibodies) or SOST was associated with increased concentrations of the factors.
Osterix (show SP7 Antibodies) and RUNX2 (show RUNX2 Antibodies) are transcriptional regulators of sclerostin in human bone
Sclerostin But Not Dickkopf-1 (show DKK1 Antibodies) has roles in increasing prevalence of osteoporotic fracture and lower bone mineral density in postmenopausal Korean women
An association was found between rs851054 of the SOST promoter and the fracture rate during childhood osteogenesis imperfecta (show COL1A2 Antibodies).
Since adipocytes do not produce sclerostin, these findings suggest an unexplored endocrine function for sclerostin that facilitates communication between the skeleton and adipose tissue.
A microtubule-dependent mechanotransduction pathway that linked fluid shear stress to reactive oxygen species and calcium (Ca2 (show CA2 Antibodies)+) signals that led to a reduction in sclerostin abundance in cultured osteocytes.
osteoclast-derived LIF (show LIF Antibodies) regulates bone turnover through sclerostin expression.
our study provided histological evidences that sclerostin tends to be secreted in osteocytes of remodeled mature bone, while FGF23 (show FGF23 Antibodies) would be differently synthesized in osteoblasts and osteocytes according to the developmental stages
These results show that osteocytes and/or osteoblasts secrete factors regulating beige (show LYST Antibodies) adipogenesis, at least in part, through the Wnt (show WNT2 Antibodies)-signaling inhibitor sclerostin.
In vivo muCT analysis of cortical bone at age 1 and 3 months confirmed increased thickness in Sost-/-mice, but revealed no cortical abnormalities in single Gja1 (show GJA1 Antibodies)+/-or Sost+/-mice
loss of BMP signaling specifically in osteocytes dramatically increases bone mass presumably through simultaneous inhibition of RANKL (show TNFSF11 Antibodies) and SOST, leading to osteoclast inhibition and Wnt (show WNT2 Antibodies) activation together.
humanized Multiple Myeloma xenograft mouse model bearing human MM cells (NOD-SCID.CB17 male mice injected intravenously with 2.5 million of MM1 (show PFDN5 Antibodies).S-Luc-GFP cells) demonstrated significantly higher concentrations of mouse-derived sclerostin, suggesting a microenvironmental source of sclerostin.
Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin
Osteocyte-derived molecule sclerostin drives bone marrow adipogenesis.
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.