anti-Sclerostin (SOST) Antibodies

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Additionally we are shipping Sclerostin Kits (67) and Sclerostin Proteins (21) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SOST 50964 Q9BQB4
SOST 74499 Q99P68
SOST 80722 Q99P67
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Top anti-Sclerostin Antibodies at antibodies-online.com

Showing 10 out of 141 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-SOST Antibody (N-term) Pab (ABIN390193) in mouse liver tissue lysates (35 µg/lane). SOST (arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with SOST antibody (N-term)(ABIN390193), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of SOST Antibody (Center) (ABIN390194) in mouse lung tissue lysates (35 µg/lane). SOST (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with SOST antibody (Center)(ABIN390194), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB SOST Antibody (N-term)  western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the SOST antibody detected the SOST protein (arrow). Anti-SOST Antibody (N-term) at 1:500 dilution + human kidney lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 24 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:500 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human kidney labeled with Rabbit Anti-Sclerostin Polyclonal Antibody, Unconjugated (ABIN1714867) at 1:200 followed by conjugation to the secondary antibody and DAB staining Lane 1: mouse lung probed with Rabbit Anti-Sclerostin Polyclonal Antibody, Unconjugated  at 1:5000 for 90 min at 37˚C. 100 μL Log in to see 14 to 21 Days
$306.90
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL Log in to see 16 Days
$221.38
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg Log in to see 13 to 16 Days
$350.00
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Mouse Tissue 100 μg Log in to see 13 to 16 Days
$360.00
Details

SOST Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Sclerostin Antibodies

  1. Human Polyclonal Sclerostin Primary Antibody for EIA, IHC (p) - ABIN358751 : Semenov, He: LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST. in The Journal of biological chemistry 2006 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal Sclerostin Primary Antibody for IHC (p), WB - ABIN390193 : Lin, Lin, Chang, Wang, Lai: Single-pulsed electromagnetic field therapy increases osteogenic differentiation through Wnt signaling pathway and sclerostin downregulation. in Bioelectromagnetics 2015 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Sclerostin Interaction Partners

Human Sclerostin (SOST) interaction partners

  1. In our cohort of pregnant women, sclerostin and DKK1 (show DKK1 Antibodies) were not associated with any adverse metabolic profile, and possibly do not play relevant roles in the pathophysiology of gestational diabetes mellitus.

  2. Sclerostin increased after exercise in comparison to baseline (mean +/- SEM: 410 +/- 27 vs. 290 +/- 19 pg/mL; p < 0.001) corresponding to an increase of +44.3 +/-5.5%

  3. serum sclerostin levels correlated positively with carotid intima-media thickness and inversely with the augmentation index, a marker of arterial stiffness

  4. The difference of serum sclerostin levels in Ankylosing Spondylitis and Rheumatoid Arthritis patients was not significantly different from HC, indicating that the sclerostin may not associate with the development of Ankylosing Spondylitis and Rheumatoid Arthritis.

  5. SOST gene silencing promotes the proliferation, invasion, and migration, and inhibits apoptosis of osteosarcoma cells by activating Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway

  6. No difference was found in the serum sclerostin levels between the hyperthyroidism patients and healthy control.

  7. Positivity of RANKL (show TNFSF11 Antibodies) and anti-CCP2 (show AGBL2 Antibodies) yielded significant risk for progression with negativity for both as reference. No single nucleotide polymorphism encoding TNFSF11 (show TNFSF11 Antibodies) or SOST was associated with increased concentrations of the factors.

  8. Osterix (show SP7 Antibodies) and RUNX2 (show RUNX2 Antibodies) are transcriptional regulators of sclerostin in human bone

  9. Sclerostin But Not Dickkopf-1 (show DKK1 Antibodies) has roles in increasing prevalence of osteoporotic fracture and lower bone mineral density in postmenopausal Korean women

  10. An association was found between rs851054 of the SOST promoter and the fracture rate during childhood osteogenesis imperfecta (show COL1A2 Antibodies).

Mouse (Murine) Sclerostin (SOST) interaction partners

  1. Since adipocytes do not produce sclerostin, these findings suggest an unexplored endocrine function for sclerostin that facilitates communication between the skeleton and adipose tissue.

  2. A microtubule-dependent mechanotransduction pathway that linked fluid shear stress to reactive oxygen species and calcium (Ca2 (show CA2 Antibodies)+) signals that led to a reduction in sclerostin abundance in cultured osteocytes.

  3. osteoclast-derived LIF (show LIF Antibodies) regulates bone turnover through sclerostin expression.

  4. our study provided histological evidences that sclerostin tends to be secreted in osteocytes of remodeled mature bone, while FGF23 (show FGF23 Antibodies) would be differently synthesized in osteoblasts and osteocytes according to the developmental stages

  5. These results show that osteocytes and/or osteoblasts secrete factors regulating beige (show LYST Antibodies) adipogenesis, at least in part, through the Wnt (show WNT2 Antibodies)-signaling inhibitor sclerostin.

  6. In vivo muCT analysis of cortical bone at age 1 and 3 months confirmed increased thickness in Sost-/-mice, but revealed no cortical abnormalities in single Gja1 (show GJA1 Antibodies)+/-or Sost+/-mice

  7. loss of BMP signaling specifically in osteocytes dramatically increases bone mass presumably through simultaneous inhibition of RANKL (show TNFSF11 Antibodies) and SOST, leading to osteoclast inhibition and Wnt (show WNT2 Antibodies) activation together.

  8. humanized Multiple Myeloma xenograft mouse model bearing human MM cells (NOD-SCID.CB17 male mice injected intravenously with 2.5 million of MM1 (show PFDN5 Antibodies).S-Luc-GFP cells) demonstrated significantly higher concentrations of mouse-derived sclerostin, suggesting a microenvironmental source of sclerostin.

  9. Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin

  10. Osteocyte-derived molecule sclerostin drives bone marrow adipogenesis.

Sclerostin (SOST) Antigen Profile

Protein Summary

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Gene names and symbols associated with anti-Sclerostin (SOST) Antibodies

  • sclerostin (LOC100313724) antibody
  • sclerostin (SOST) antibody
  • sclerostin (Sost) antibody
  • 5430411E23Rik antibody
  • CDD antibody
  • LOC100313724 antibody
  • VBCH antibody

Protein level used designations for anti-Sclerostin (SOST) Antibodies

sclerostin , sclerosteosis

GENE ID SPECIES
100313724 Saccoglossus kowalevskii
50964 Homo sapiens
74499 Mus musculus
80722 Rattus norvegicus
490948 Canis lupus familiaris
100730713 Cavia porcellus
282880 Bos taurus
429784 Gallus gallus
101114123 Ovis aries
100513306 Sus scrofa
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