Sclerostin Proteins (SOST)

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Additionally we are shipping Sclerostin Antibodies (128) and Sclerostin Kits (64) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SOST 50964 Q9BQB4
SOST 74499 Q99P68
SOST 80722 Q99P67
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Top Sclerostin Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Human Cells Human His tag 50 μg Log in to see 20 to 21 Days
$382.80
Details
Human Cells Rat His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
HEK-293 Cells Human Biotin,His tag Biotinylated Human SOST on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 200 μg Log in to see 2 to 3 Days
$1,375.00
Details
Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$522.50
Details
HEK-293 Cells Human His tag   0.1 mg Log in to see 2 to 3 Days
$687.50
Details
Human Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
Details
Mammalian Cells Mouse His tag   10 μg Log in to see 4 Days
$234.03
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,440.17
Details

SOST Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, ,
Mouse (Murine) , ,
,
Rat (Rattus) ,

More Proteins for Sclerostin (SOST) Interaction Partners

Human Sclerostin (SOST) interaction partners

  1. Positivity of RANKL (show TNFSF11 Proteins) and anti-CCP2 yielded significant risk for progression with negativity for both as reference. No single nucleotide polymorphism encoding TNFSF11 (show TNFSF11 Proteins) or SOST was associated with increased concentrations of the factors.

  2. Osterix (show SP7 Proteins) and RUNX2 (show RUNX2 Proteins) are transcriptional regulators of sclerostin in human bone

  3. Sclerostin But Not Dickkopf-1 has roles in increasing prevalence of osteoporotic fracture and lower bone mineral density in postmenopausal Korean women

  4. An association was found between rs851054 of the SOST promoter and the fracture rate during childhood osteogenesis imperfecta (show COL1A2 Proteins).

  5. High serum levels of sclerostin and Dkk-1 (show DKK1 Proteins) are associated with acute ischaemic stroke

  6. The increased expression of sclerostin in the liver and the association with histologic cholangitis may explain the high serum levels of this protein in patients with primary biliary cirrhosis.

  7. SOST silencing promotes the proliferation, invasion and migration, and decreases the apoptosis of human retinoblastoma cells by activating the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway.

  8. Sclerostin concentrations in serum significantly decreased and IGF-I (show IGF1 Proteins) significantly increased after 12months of resistance training or JUMP.

  9. observed an association between sclerostin levels with fasting insulin (show INS Proteins) levels and homoeostatic model assessment-insulin (show INS Proteins) resistance, but there was no clear association with type 2 diabetes risk.

  10. Sclerostin levels in KTR are normal and influenced more by bone turnover than by eGFR (show EGFR Proteins). Its involvement with other hormones of mineral homeostasis (FGF23 (show FGF23 Proteins)/Klotho (show KL Proteins) and Vitamin D) is part of the sophisticated cross-talk between bone and the kidney

Mouse (Murine) Sclerostin (SOST) interaction partners

  1. These results show that osteocytes and/or osteoblasts secrete factors regulating beige adipogenesis, at least in part, through the Wnt (show WNT2 Proteins)-signaling inhibitor sclerostin.

  2. In vivo muCT analysis of cortical bone at age 1 and 3 months confirmed increased thickness in Sost-/-mice, but revealed no cortical abnormalities in single Gja1 (show GJA1 Proteins)+/-or Sost+/-mice

  3. loss of BMP signaling specifically in osteocytes dramatically increases bone mass presumably through simultaneous inhibition of RANKL (show TNFSF11 Proteins) and SOST, leading to osteoclast inhibition and Wnt (show WNT2 Proteins) activation together.

  4. humanized Multiple Myeloma xenograft mouse model bearing human MM cells (NOD-SCID.CB17 male mice injected intravenously with 2.5 million of MM1 (show PFDN5 Proteins).S-Luc-GFP cells) demonstrated significantly higher concentrations of mouse-derived sclerostin, suggesting a microenvironmental source of sclerostin.

  5. Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin

  6. Osteocyte-derived molecule sclerostin drives bone marrow adipogenesis.

  7. complete absence of sclerostin has only minor effects on chronic kidney disease-induced bone loss in mice.

  8. In mice, sclerostin deficiency hastened reparative dentinogenesis after pulp injury, suggesting that the inhibition of sclerostin may constitute a promising therapeutic strategy for improving the healing of damaged pulps.

  9. These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.

  10. Sclerostin inhibits angiotensin II-induced aortic aneurysm and atherosclerosis via wnt (show WNT2 Proteins) signaling pathway inhibition.

Sclerostin (SOST) Protein Profile

Protein Summary

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Gene names and symbols associated with Sclerostin Proteins (SOST)

  • sclerostin (LOC100313724)
  • sclerostin (SOST)
  • sclerostin (Sost)
  • 5430411E23Rik protein
  • CDD protein
  • LOC100313724 protein
  • VBCH protein

Protein level used designations for Sclerostin Proteins (SOST)

sclerostin , sclerosteosis

GENE ID SPECIES
100313724 Saccoglossus kowalevskii
50964 Homo sapiens
74499 Mus musculus
80722 Rattus norvegicus
490948 Canis lupus familiaris
100730713 Cavia porcellus
282880 Bos taurus
429784 Gallus gallus
101114123 Ovis aries
100513306 Sus scrofa
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