Sclerostin Proteins (SOST)

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Additionally we are shipping Sclerostin Antibodies (140) and Sclerostin Kits (68) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SOST 50964 Q9BQB4
SOST 74499 Q99P68
SOST 80722 Q99P67
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Top Sclerostin Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Human Cells Human His tag 50 μg Log in to see 14 to 16 Days
$382.80
Details
Human Cells Rat His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
HEK-293 Cells Human Biotin,His tag Biotinylated Human SOST on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 200 μg Log in to see 2 to 3 Days
$1,375.00
Details
Human Cells Human His tag   50 μg Log in to see 4 Days
$522.50
Details
Human Cells Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,440.17
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,451.17
Details
Yeast REACT_Green monkey His tag   1 mg Log in to see 60 to 71 Days
$2,454.83
Details

SOST Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) , ,
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Rat (Rattus) , ,

More Proteins for Sclerostin (SOST) Interaction Partners

Human Sclerostin (SOST) interaction partners

  1. Higher Sclerostin/SOST expression is associated with lower percentage of circulatory blasts and better prognosis in patients with myelofibrosis.

  2. Sclerosteosis is caused by loss-of-function mutations in the SOST gene which encodes a secreted glycoprotein, sclerostin--{REVIEW}

  3. Serum sclerostin level was not an independent predictor of mortality in Maintenance Hemodialysis Patients

  4. these results suggest a possible role of sclerostin in the identification of ankylosing spondylitis patients

  5. important role for SOST SNP rs1877632 and VDR SNPs rs10735810 and rs731236 in the pathophysiology of stress fracture

  6. In our cohort of pregnant women, sclerostin and DKK1 (show DKK1 Proteins) were not associated with any adverse metabolic profile, and possibly do not play relevant roles in the pathophysiology of gestational diabetes mellitus.

  7. Sclerostin increased after exercise in comparison to baseline (mean +/- SEM: 410 +/- 27 vs. 290 +/- 19 pg/mL; p < 0.001) corresponding to an increase of +44.3 +/-5.5%

  8. serum sclerostin levels correlated positively with carotid intima-media thickness and inversely with the augmentation index, a marker of arterial stiffness

  9. The difference of serum sclerostin levels in Ankylosing Spondylitis and Rheumatoid Arthritis patients was not significantly different from HC, indicating that the sclerostin may not associate with the development of Ankylosing Spondylitis and Rheumatoid Arthritis.

  10. SOST gene silencing promotes the proliferation, invasion, and migration, and inhibits apoptosis of osteosarcoma cells by activating Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway

Mouse (Murine) Sclerostin (SOST) interaction partners

  1. The SOST gene inhibited the expression of COL1, OCN, and OPN (show SPP1 Proteins), reduced the activity of alkaline phosphatase, and increased the expression of LPL (show LPL Proteins) and PPARgamma (show PPARG Proteins).

  2. Since adipocytes do not produce sclerostin, these findings suggest an unexplored endocrine function for sclerostin that facilitates communication between the skeleton and adipose tissue.

  3. A microtubule-dependent mechanotransduction pathway that linked fluid shear stress to reactive oxygen species and calcium (Ca2 (show CA2 Proteins)+) signals that led to a reduction in sclerostin abundance in cultured osteocytes.

  4. osteoclast-derived LIF (show LIF Proteins) regulates bone turnover through sclerostin expression.

  5. our study provided histological evidences that sclerostin tends to be secreted in osteocytes of remodeled mature bone, while FGF23 (show FGF23 Proteins) would be differently synthesized in osteoblasts and osteocytes according to the developmental stages

  6. These results show that osteocytes and/or osteoblasts secrete factors regulating beige adipogenesis, at least in part, through the Wnt (show WNT2 Proteins)-signaling inhibitor sclerostin.

  7. In vivo muCT analysis of cortical bone at age 1 and 3 months confirmed increased thickness in Sost-/-mice, but revealed no cortical abnormalities in single Gja1 (show GJA1 Proteins)+/-or Sost+/-mice

  8. loss of BMP signaling specifically in osteocytes dramatically increases bone mass presumably through simultaneous inhibition of RANKL (show TNFSF11 Proteins) and SOST, leading to osteoclast inhibition and Wnt (show WNT2 Proteins) activation together.

  9. humanized Multiple Myeloma xenograft mouse model bearing human MM cells (NOD-SCID.CB17 male mice injected intravenously with 2.5 million of MM1 (show PFDN5 Proteins).S-Luc-GFP cells) demonstrated significantly higher concentrations of mouse-derived sclerostin, suggesting a microenvironmental source of sclerostin.

  10. Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin

Sclerostin (SOST) Protein Profile

Protein Summary

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Gene names and symbols associated with Sclerostin Proteins (SOST)

  • sclerostin (LOC100313724)
  • sclerostin (SOST)
  • sclerostin (Sost)
  • 5430411E23Rik protein
  • CDD protein
  • LOC100313724 protein
  • VBCH protein

Protein level used designations for Sclerostin Proteins (SOST)

sclerostin , sclerosteosis

GENE ID SPECIES
100313724 Saccoglossus kowalevskii
50964 Homo sapiens
74499 Mus musculus
80722 Rattus norvegicus
490948 Canis lupus familiaris
100730713 Cavia porcellus
282880 Bos taurus
429784 Gallus gallus
101114123 Ovis aries
100513306 Sus scrofa
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