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SFMBT1 shares high similarity with the Drosophila Scm (sex comb on midleg) gene.
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copy number variation analysis identified deletions in SFMBT1 associated with fasting plasma glucose in a Han Chinese population
The present study demonstrates that a copy number loss within intron 2 of the SFMBT1 gene may be a genetic risk factor for shunt-responsive definite iNPH.
The malignant brain tumor (MBT (show PRTN3 Proteins)) domain protein SFMBT1 is an integral histone reader subunit of the LSD1 (show KDM1A Proteins) demethylase (show MBD2 Proteins) complex for chromatin association and epithelial-to-mesenchymal transition.
When bound to its gene targets, SFMBT1 recruits its associated proteins and causes chromatin compaction and transcriptional repression
novel mechanisms accounting for SFMBT1-mediated transcription repression and revealed an essential role of Sfmbt1 in regulating MyoD (show MYOD1 Proteins)-mediated transcriptional silencing
Data identified IGF1 (show IGF1 Proteins), SLC4A4 (show SLC4A4 Proteins), WWOX (show WWOX Proteins), and SFMBT1 as hypertension susceptibility genes by gene based association scan and gene expression analysis.
A segmental copy number loss of the SFMBT1 gene may be involved in the pathological process in some individuals with ventriculomegaly/idiopathic normal pressure hydrocephalus.
The tandem MBT (show PRTN3 Proteins) repeats form a functional structure required for biological activity of hSFMBT and predict similar properties for other MBT (show PRTN3 Proteins) domain-containing proteins.
This gene shares high similarity with the Drosophila Scm (sex comb on midleg) gene. It encodes a protein which contains four malignant brain tumor repeat (mbt) domains and may be involved in antigen recognition.
Scm-like with four mbt domains 1
, scm-like with four MBT domains protein 1-like
, Scm-related gene containing four mbt domains
, Scm-related gene product containing four mbt domains
, renal ubiquitous protein 1
, scm-like with four MBT domains protein 1
, Scm-related gene containing four mbt domains 1