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SCRIB encodes a protein that was identified as being similar to the Drosophila scribble protein.
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Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 (show RPS6KA2 Proteins) and MCC (show MCC Proteins) were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 (show RPS6KA2 Proteins) = ribosomal protein S6 kinase 2 (show RPS6KA3 Proteins); MCC (show MCC Proteins) = mutated in colorectal cancer protein)
Scrib inhibits liver cancer cell proliferation by suppressing the expression of three oncogenes, Yap1 (show YAP1 Proteins), c-Myc (show MYC Proteins) and cyclin D1 (show CCND1 Proteins), thereby functioning as a tumor suppressor in liver cancer.
In this study the authors show that human Scrib expression is required for maintaining high levels of human papillomavirus type 18 E6 protein in HeLa cells.
Data suggest that Scribble PDZ-domain-1 and PDZ-domain-3 are major domains that interact with beta-PIX (show ARHGEF7 Proteins) and exhibit distinct binding hierarchy in interactions between individual Scribble PDZ domains and beta-PIX (show ARHGEF7 Proteins). (Scribble = scribbled planar cell polarity protein; beta-PIX (show ARHGEF7 Proteins) = Rho guanine nucleotide exchange factor 7 (show ARHGEF7 Proteins))
inhibiting acyl thioesterase 2 restores balance to the Scrib palmitoylation cycle, promoting membrane re-localization and growth attenuation
sequencing analysis of SCRIB1 in 473 NTD patients led to the identification of 5 rare heterozygous missense mutations that were predicted to be pathogenic. Two of these mutations, p.Gly263Ser and p.Gln808His, and 2 mouse NTD mutations, p.Ile285Lys and p.Glu814Gly, affected Scrib1 membrane localization and its modulating role of Par-3 (show F2RL2 Proteins) and Vangl1 (show Vangl1 Proteins) localization.
a new function for Scribble in Rho regulation that entails positioning of DLC3 (show STARD8 Proteins) GAP activity at cell junctions in polarized epithelial cells, is reported.
Low Scribble expression in the primary breast tumor was correlated to prognosis in estrogen receptor (show ESR1 Proteins)-positive breast cancer patients.
Suggest a role for Plexin-B1 as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A regulating cell migration via Scrib.
SCRIB uncouples reactive oxygen species-dependent bacterial killing activity from M1 polarization and inflammatory functions of macrophages
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
protein scribble homolog
, scribbled homolog